Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Katarzyna M. Grzes"'
Autor:
Matteo Villa, David E. Sanin, Petya Apostolova, Mauro Corrado, Agnieszka M. Kabat, Carmine Cristinzio, Annamaria Regina, Gustavo E. Carrizo, Nisha Rana, Michal A. Stanczak, Francesc Baixauli, Katarzyna M. Grzes, Jovana Cupovic, Francesca Solagna, Alexandra Hackl, Anna-Maria Globig, Fabian Hässler, Daniel J. Puleston, Beth Kelly, Nina Cabezas-Wallscheid, Peter Hasselblatt, Bertram Bengsch, Robert Zeiser, Sagar, Joerg M. Buescher, Edward J. Pearce, Erika L. Pearce
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Immune cells must adapt to different environments during the course of an immune response. Here we study the adaptation of CD8+ T cells to the intestinal microenvironment and how this process shapes the establishment of the CD8+ T cell pool.
Externí odkaz:
https://doaj.org/article/94dc27161c6a48b2b42944d1f1be38af
Autor:
Angela Castoldi, David E. Sanin, Nikki van Teijlingen Bakker, Cristhiane F. Aguiar, Lauar de Brito Monteiro, Nisha Rana, Katarzyna M. Grzes, Agnieszka M. Kabat, Jonathan Curtis, Alanna M. Cameron, George Caputa, Tiago Antônio de Souza, Fabrício O. Souto, Joerg M. Buescher, Joy Edwards-Hicks, Erika L. Pearce, Edward J. Pearce, Niels Olsen Saraiva Camara
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107719- (2023)
Summary: Little is known about the effects of high-fat diet (HFD)-induced obesity on resident colonic lamina propria (LP) macrophages (LPMs) function and metabolism. Here, we report that obesity and diabetes resulted in increased macrophage infiltrat
Externí odkaz:
https://doaj.org/article/70708d6c2e6b42e9aa409bf406d9bad6
Autor:
Julianty Frost, Carles Galdeano, Pedro Soares, Morgan S. Gadd, Katarzyna M. Grzes, Lucy Ellis, Ola Epemolu, Satoko Shimamura, Marcus Bantscheff, Paola Grandi, Kevin D. Read, Doreen A. Cantrell, Sonia Rocha, Alessio Ciulli
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Small molecule probes used to trigger hypoxic response by activating hypoxia inducible factors (HIFs) often lack specificity. Here the authors report a potent small molecule inhibitor that induces hypoxic response by blocking VHL:HIF interactions, pr
Externí odkaz:
https://doaj.org/article/3040359d09be44dd8ac2502767cf24e9
Autor:
Jing Qiu, Matteo Villa, David E. Sanin, Michael D. Buck, David O’Sullivan, Reagan Ching, Mai Matsushita, Katarzyna M. Grzes, Frances Winkler, Chih-Hao Chang, Jonathan D. Curtis, Ryan L. Kyle, Nikki Van Teijlingen Bakker, Mauro Corrado, Fabian Haessler, Francesca Alfei, Joy Edwards-Hicks, Leonard B. Maggi, Jr., Dietmar Zehn, Takeshi Egawa, Bertram Bengsch, Ramon I. Klein Geltink, Thomas Jenuwein, Edward J. Pearce, Erika L. Pearce
Publikováno v:
Cell Reports, Vol 27, Iss 7, Pp 2063-2074.e5 (2019)
Summary: Competition for nutrients like glucose can metabolically restrict T cells and contribute to their hyporesponsiveness during cancer. Metabolic adaptation to the surrounding microenvironment is therefore key for maintaining appropriate cell fu
Externí odkaz:
https://doaj.org/article/4ea68f59d3e14e4bbf5687d54711cf4f
Autor:
Diana Vara-Ciruelos, Madhumita Dandapani, Fiona M. Russell, Katarzyna M. Grzes, Abdelmadjid Atrih, Marc Foretz, Benoit Viollet, Douglas J. Lamont, Doreen A. Cantrell, D. Grahame Hardie
Publikováno v:
Cell Reports, Vol 27, Iss 3, Pp 690-698.e4 (2019)
Summary: AMPK acts downstream of the tumor suppressor LKB1, yet its role in cancer has been controversial. AMPK is activated by biguanides, such as metformin and phenformin, and metformin use in diabetics has been associated with reduced cancer risk.
Externí odkaz:
https://doaj.org/article/db8d81d633214b928b39b3ad83b03e1d
Autor:
Joy Edwards-Hicks, Petya Apostolova, Joerg M. Buescher, Hannes Maib, Michal A. Stanczak, Mauro Corrado, Ramon I. Klein Geltink, Maria Elena Maccari, Matteo Villa, Gustavo E. Carrizo, David E. Sanin, Francesc Baixauli, Beth Kelly, Jonathan D. Curtis, Fabian Haessler, Annette Patterson, Cameron S. Field, George Caputa, Ryan L. Kyle, Melanie Soballa, Minsun Cha, Harry Paul, Jacob Martin, Katarzyna M. Grzes, Lea Flachsmann, Michael Mitterer, Liang Zhao, Frances Winkler, David Ali Rafei-Shamsabadi, Frank Meiss, Bertram Bengsch, Robert Zeiser, Daniel J. Puleston, David O’Sullivan, Edward J. Pearce, Erika L. Pearce
Publikováno v:
Nature Immunology
How lipidome changes support CD8+ effector T (Teff) cell differentiation is not well understood. Here we show that, although naive T cells are rich in polyunsaturated phosphoinositides (PIPn with 3-4 double bonds), Teff cells have unique PIPn marked
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0bcbbf423f9a7b51630fb44cecc15a8
https://hdl.handle.net/21.11116/0000-000D-12D6-D21.11116/0000-000D-12D8-B
https://hdl.handle.net/21.11116/0000-000D-12D6-D21.11116/0000-000D-12D8-B
Autor:
Angela Castoldi, David E. Sanin, Nikki van Teijlingen Bakker, Christiane F. Aguiar, Lauar de Brito Monteiro, Nisha Rana, Katarzyna M. Grzes, Agnieszka M. Kabat, Jonathan Curtis, Alanna M. Cameron, George Caputa, Tiago Antônio de Souza, Fabrício O. Souto, Joerg M. Buescher, Joy Edwards-Hicks, Erika L. Pearce, Edward J. Pearce, Niels O.S. Camara
Little is known about the effects of high fat diet (HFD)-induced obesity on resident colonic lamina propria (LP) macrophages (LPMs) function and metabolism. Here, we report that obesity and diabetes resulted in increased macrophage infiltration in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a63ed93c9d661cefeb718b6e822e3bf1
https://doi.org/10.1101/2022.12.20.521239
https://doi.org/10.1101/2022.12.20.521239
Autor:
Agnieszka M. Kabat, Alexandra Hackl, David E. Sanin, Patrice Zeis, Katarzyna M. Grzes, Francesc Baixauli, Ryan Kyle, George Caputa, Joy Edwards-Hicks, Matteo Villa, Nisha Rana, Jonathan D. Curtis, Angela Castoldi, Jovana Cupovic, Leentje Dreesen, Maria Sibilia, J. Andrew Pospisilik, Joseph F. Urban, Dominic Grün, Erika L. Pearce, Edward J. Pearce
Publikováno v:
Science Immunology
Type 2 immunity is associated with adipose tissue (AT) homeostasis and infection with parasitic helminths, but whether AT participates in immunity to these parasites is unknown. We found that the fat content of mesenteric AT (mAT) declined in mice du
Autor:
Agnieszka M, Kabat, Alexandra, Hackl, David E, Sanin, Patrice, Zeis, Katarzyna M, Grzes, Francesc, Baixauli, Ryan, Kyle, George, Caputa, Joy, Edwards-Hicks, Matteo, Villa, Nisha, Rana, Jonathan D, Curtis, Angela, Castoldi, Jovana, Cupovic, Leentje, Dreesen, Maria, Sibilia, J Andrew, Pospisilik, Joseph F, Urban, Dominic, Grün, Erika L, Pearce, Edward J, Pearce
Publikováno v:
Science immunology. 7(76)
Type 2 immunity is associated with adipose tissue (AT) homeostasis and infection with parasitic helminths, but whether AT participates in immunity to these parasites is unknown. We found that the fat content of mesenteric AT (mAT) declined in mice du
Autor:
Francesc Baixauli, Klara Piletic, Daniel J. Puleston, Matteo Villa, Cameron S. Field, Lea J. Flachsmann, Andrea Quintana, Nisha Rana, Joy Edwards-Hicks, Mai Matsushita, Michal A. Stanczak, Katarzyna M. Grzes, Agnieszka M. Kabat, Mario Fabri, George Caputa, Beth Kelly, Mauro Corrado, Yaarub Musa, Katarzyna J. Duda, Gerhard Mittler, David O’Sullivan, Hiromi Sesaki, Thomas Jenuwein, Joerg M. Buescher, Edward J. Pearce, David E. Sanin, Erika L. Pearce
Publikováno v:
Nature
CD4+ T cell differentiation requires metabolic reprogramming to fulfil the bioenergetic demands of proliferation and effector function, and enforce specific transcriptional programmes1-3. Mitochondrial membrane dynamics sustains mitochondrial process
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61b176219f4d5bd0e37689d90bf3777d
https://europepmc.org/articles/PMC9844518/
https://europepmc.org/articles/PMC9844518/