Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Katarzyna M. Grochowska"'
Autor:
Katarzyna M. Grochowska, Marit Sperveslage, Rajeev Raman, Antonio V. Failla, Dawid Głów, Christian Schulze, Laura Laprell, Boris Fehse, Michael R. Kreutz
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112998- (2023)
Summary: The complex morphology of neurons poses a challenge for proteostasis because the majority of lysosomal degradation machinery is present in the cell soma. In recent years, however, mature lysosomes were identified in dendrites, and a fraction
Externí odkaz:
https://doaj.org/article/c3054975b675454d8630ed3d26b78003
Autor:
Alessandro Dario Confettura, Eleonora Cuboni, Mohamed Rafeet Ammar, Shaobo Jia, Guilherme M. Gomes, PingAn Yuanxiang, Rajeev Raman, Tingting Li, Katarzyna M. Grochowska, Robert Ahrends, Anna Karpova, Alexander Dityatev, Michael R. Kreutz
Publikováno v:
Translational Neurodegeneration, Vol 11, Iss 1, Pp 1-18 (2022)
Abstract Background The metabolic syndrome is a consequence of modern lifestyle that causes synaptic insulin resistance and cognitive deficits and that in interaction with a high amyloid load is an important risk factor for Alzheimer's disease. It ha
Externí odkaz:
https://doaj.org/article/8050b454059242799298a70205d8078a
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 13 (2021)
Pyramidal neurons exhibit a complex dendritic tree that is decorated by a huge number of spine synapses receiving excitatory input. Synaptic signals not only act locally but are also conveyed to the nucleus of the postsynaptic neuron to regulate gene
Externí odkaz:
https://doaj.org/article/89f3917176054208a268f29737d840f6
Autor:
Katarzyna M Grochowska, Guilherme M Gomes, Rajeev Raman, Rahul Kaushik, Liudmila Sosulina, Hiroshi Kaneko, Anja M Oelschlegel, PingAn Yuanxiang, Irene Reyes‐Resina, Gonca Bayraktar, Sebastian Samer, Christina Spilker, Marcel S Woo, Markus Morawski, Jürgen Goldschmidt, Manuel A Friese, Steffen Rossner, Gemma Navarro, Stefan Remy, Carsten Reissner, Anna Karpova, Michael R Kreutz
Publikováno v:
The EMBO journal, 42(4):e112453
The EMBO journal 42(4), e112453 (2023). doi:10.15252/embj.2022112453
The EMBO journal 42(4), e112453 (2023). doi:10.15252/embj.2022112453
Synaptic dysfunction caused by soluble β-amyloid peptide (Aβ) is a hallmark of early-stage Alzheimer's disease (AD), and is tightly linked to cognitive decline. By yet unknown mechanisms, Aβ suppresses the transcriptional activity of cAMP-responsi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10b4e66e4bdf94453ba2c55d601ee9d1
https://www.embopress.org/doi/full/10.15252/embj.2022112453#support-information-section
https://www.embopress.org/doi/full/10.15252/embj.2022112453#support-information-section
Autor:
Maria Andres-Alonso, Katarzyna M. Grochowska, Eckart D. Gundelfinger, Anna Karpova, Michael R. Kreutz
Publikováno v:
Molecular and cellular neuroscience 125, 103854 (2023). doi:10.1016/j.mcn.2023.103854
The extreme length of neuronal processes poses a challenge for synapse-to-nucleus communication. In response to this challenge several different mechanisms have evolved in neurons to couple synaptic activity to the regulation of gene expression. One
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::708faf9276945b4ccd6be28ce138ca5a
Publikováno v:
The EMBO journal, 41(7):e110057
The EMBO journal 41(7), e110057 (2022). doi:10.15252/embj.2021110057
The EMBO journal 41(7), e110057 (2022). doi:10.15252/embj.2021110057
Synaptic function crucially relies on the constant supply and removal of neuronal membranes. The morphological complexity of neurons poses a significant challenge for neuronal protein transport since the machineries for protein synthesis and degradat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa05bd6d8bb51a27119bc0d73478ae71
https://www.embopress.org/doi/full/10.15252/embj.2021110057#support-information-section
https://www.embopress.org/doi/full/10.15252/embj.2021110057#support-information-section
Autor:
Christina Spilker, Sven Nullmeier, Katarzyna M Grochowska, Anne Schumacher, Ioana Butnaru, Tamar Macharadze, Guilherme M Gomes, PingAn Yuanxiang, Gonca Bayraktar, Carolin Rodenstein, Carolin Geiseler, Angela Kolodziej, Jeffrey Lopez-Rojas, Dirk Montag, Frank Angenstein, Julia Bär, Wolfgang D'Hanis, Thomas Roskoden, Marina Mikhaylova, Eike Budinger, Frank W Ohl, Oliver Stork, Ana C Zenclussen, Anna Karpova, Herbert Schwegler, Michael R Kreutz
Publikováno v:
PLoS Genetics, Vol 12, Iss 3, p e1005907 (2016)
Jacob, the protein encoded by the Nsmf gene, is involved in synapto-nuclear signaling and docks an N-Methyl-D-Aspartate receptor (NMDAR)-derived signalosome to nuclear target sites like the transcription factor cAMP-response-element-binding protein (
Externí odkaz:
https://doaj.org/article/be102f6df7474cccbf12c201592fe231
Publikováno v:
Neuroscience. 280:340-350
Long-lasting changes in neuronal excitability require activity-dependent gene expression and therefore the transduction of synaptic signals to the nucleus. Synaptic activity is rapidly relayed to the nucleus by membrane depolarization and the propaga
Autor:
Stephan Schilling, Michael R. Kreutz, Julia Bär, Michaela Schweizer, Hans-Ulrich Demuth, PingAn Yuanxiang, Gemma Navarro Brugal, Katarzyna M. Grochowska, Arthur Bikbaev, Rajeev Raman, Giriraj Sahu
Publikováno v:
EMBO reports
EMBO reports 18(6), 962-981 (2017). doi:10.15252/embr.201643519
EMBO reports 18(6), 962-981 (2017). doi:10.15252/embr.201643519
Oligomeric amyloid-β (Aβ) 1-42 disrupts synaptic function at an early stage of Alzheimer's disease (AD). Multiple posttranslational modifications of Aβ have been identified, among which N-terminally truncated forms are the most abundant. It is not
Publikováno v:
Rare Diseases
Mutations in the NSMF gene have been related to Kallmann syndrome. Conflicting results have been reported on the subcellular localization of Jacob/NELF, the protein encoded by the NSMF gene. Some reports indicate an extracellular localization and a f