Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Katarzyna M, Soczek"'
Autor:
Carter J. Barger, Abigail K. Suwala, Katarzyna M. Soczek, Albert S. Wang, Min Y. Kim, Chibo Hong, Jennifer A. Doudna, Susan M. Chang, Joanna J. Phillips, David A. Solomon, Joseph F. Costello
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
TERT promoter mutations are the most common noncoding alterations in cancers, although some remain to be characterised. Here, the authors identify TERT promoter duplications across seven cancer types that are functionally equivalent to well-known hot
Externí odkaz:
https://doaj.org/article/a11e544533df4a98816dfb5ed7b18481
Autor:
Stefan A Zukin, Matthew R Marunde, Irina K Popova, Katarzyna M Soczek, Eva Nogales, Avinash B Patel
Publikováno v:
eLife, Vol 11 (2022)
The NuA4 protein complex acetylates histones H4 and H2A to activate both transcription and DNA repair. We report the 3.1-Å resolution cryo-electron microscopy structure of the central hub of NuA4, which flexibly tethers the histone acetyltransferase
Externí odkaz:
https://doaj.org/article/40a0833a16aa44ceba92ff7511f59cb4
Publikováno v:
eLife, Vol 7 (2018)
Gyrase is a unique type IIA topoisomerase that uses ATP hydrolysis to maintain the negatively supercoiled state of bacterial DNA. In order to perform its function, gyrase undergoes a sequence of conformational changes that consist of concerted gate o
Externí odkaz:
https://doaj.org/article/8249dafc9a8140d1bbbb7ffd690e5e61
Publikováno v:
Nature Structural & Molecular Biology. 29:395-402
Autor:
Abdullah M. Syed, Irene P. Chen, Jennifer M. Hayashi, Mir M. Khalid, Katarzyna M. Soczek, Jennifer A. Doudna, Taha Y. Taha, Melanie Ott, Alison Ciling, Takako Tabata, Bharath Sreekumar, Pei-Yi Chen
Publikováno v:
Science. 374:1626-1632
A tool to probe SARS-CoV-2 biology To develop therapies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and emerging variants, it is important to understand the viral biology and the effect of mutations. However, this is challeng
Autor:
Jillian F. Banfield, Dominik A Herbst, Eva Nogales, Connor A. Tsuchida, Katarzyna M. Soczek, Jennifer A. Doudna, Patrick Pausch, Basem Al-Shayeb
Publikováno v:
Nat Struct Mol Biol
CRISPR-CasΦ, a small RNA-guided enzyme found uniquely in bacteriophages, achieves programmable DNA cutting as well as genome editing. To investigate how the hypercompact enzyme recognizes and cleaves double-stranded DNA, we determined cryo-EM struct
Publikováno v:
Nature structuralmolecular biology. 29(4)
In bacterial defense and genome editing applications, the CRISPR-associated protein Cas9 searches millions of DNA base pairs to locate a 20-nucleotide, guide RNA-complementary target sequence that abuts a protospacer-adjacent motif (PAM). Target capt
Autor:
Abigail Suwala, Carter Barger, Katarzyna M Soczek, Albert S Wang, Min Y Kim, Chibo Hong, Jennifer A Doudna, Susan M Chang, Joanna J Phillips, David A Solomon, Joseph F Costello
Publikováno v:
Neuro-Oncology. 24:vii117-vii117
Mutations in the TERT promoter are the single most common non-coding mutation in cancer and represent the genetic underpinnings of tumor cell immortality. Beyond the two most common point mutations, G228A and G250A, which selectively recruit the ETS
Publikováno v:
Nature structural & molecular biology, vol 29, iss 4
In bacterial defense and genome editing applications, the CRISPR-associated protein Cas9 searches millions of DNA base pairs to locate a 20-nucleotide, guide-RNA-complementary target sequence that abuts a protospacer-adjacent motif (PAM)1. Target cap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a2a720601a4ba72fdf18d21efe02c20
https://doi.org/10.21203/rs.3.rs-882403/v1
https://doi.org/10.21203/rs.3.rs-882403/v1