The Structural Determinants for α1-Adrenergic/Serotonin Receptors Activity among Phenylpiperazine-Hydantoin Derivatives

Autor: Katarzyna Kucwaj-Brysz, Anna Dela, Sabina Podlewska, Marek Bednarski, Agata Siwek, Grzegorz Satała, Kinga Czarnota, Jadwiga Handzlik, Katarzyna Kieć-Kononowicz

Publikováno v: Molecules, Vol 26, Iss 22, p 7025 (2021)

Several studies confirmed the reciprocal interactions between adrenergic and serotoninergic systems and the influence of these phenomena on the pathogenesis of anxiety. Hence, searching for chemical agents with a multifunctional pharmacodynamic profi

Externí odkaz: https://doaj.org/article/c378d5c166f349a6af1c3d5be2fa4bf7

The Significance of Halogen Bonding in Ligand–Receptor Interactions: The Lesson Learned from Molecular Dynamic Simulations of the D4 Receptor

Autor: Rafał Kurczab, Katarzyna Kucwaj-Brysz, Paweł Śliwa

Publikováno v: Molecules, Vol 25, Iss 1, p 91 (2019)

Recently, a computational approach combining a structure−activity relationship library containing pairs of halogenated ligands and their corresponding unsubstituted ligands (called XSAR) with QM-based molecular docking and binding free energy calcu

Externí odkaz: https://doaj.org/article/0cdfa0a7d6444ad1b7d35d5b1b61c019

An exit beyond the pharmacophore model for 5-HT6R agents - a new strategy to gain dual 5-HT6/5-HT2A action for triazine derivatives with procognitive potential

Autor: Katarzyna Kucwaj-Brysz, Wesam Ali, Rafał Kurczab, Sylwia Sudoł-Tałaj, Natalia Wilczyńska-Zawal, Magdalena Jastrzębska-Więsek, Grzegorz Satała, Barbara Mordyl, Ewa Żesławska, null Agnieszka-Olejarz-Maciej, Kinga Czarnota, Gniewomir Latacz, Anna Partyka, Anna Wesołowska, Wojciech Nitek, Jadwiga Handzlik

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c162a0f0ba180f8a6a6560d8f91d90cc
https://ruj.uj.edu.pl/xmlui/handle/item/289043

The Phenoxyalkyltriazine Antagonists for 5-HT6 Receptor with Promising Procognitive and Pharmacokinetic Properties In Vivo in Search for a Novel Therapeutic Approach to Dementia Diseases

Autor: Sylwia Sudoł, Jadwiga Handzlik, Natalia Wilczyńska-Zawal, Gniewomir Latacz, Magdalena Jastrzębska-Więsek, Barbara Mordyl, Agnieszka Cios, Ewelina Honkisz-Orzechowska, Agnieszka Olejarz-Maciej, Grzegorz Satała, Katarzyna Kucwaj-Brysz, Anna Wesołowska, Anna Partyka

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 19
International Journal of Molecular Sciences, Vol 22, Iss 10773, p 10773 (2021)

Among the serotonin receptors, one of the most recently discovered 5-HT6 subtype is an important protein target and its ligands may play a key role in the innovative treatment of cognitive disorders. However, none of its selective ligands have reache

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2ed076a6b5c499515d39c7c7bd6c0c9

Computer-aided search for 5-arylideneimidazolone anticancer agents able to overcome ABCB1-based multidrug resistance

Autor: Małgorzata Starek, Monika Dąbrowska, Gabriella Spengler, Gniewomir Latacz, Jadwiga Handzlik, Katarzyna Kucwaj-Brysz, Aneta Kaczor, Nikoletta Szemerédi

ABCB1 modulation is an interesting strategy in the search for new anticancer agents that can overcome multidrug resistance (MDR). Hence, 17 new 5-arylideneimidazolones containing an amine moiety, as potential ABCB1 inhibitors, were designed, synthesi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c058457570a8a95e6cdcd17024be6161
https://ruj.uj.edu.pl/xmlui/handle/item/278332