Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Katarzyna Kubica"'
Autor:
Monika Wawszczak-Kasza, Piotr Lewitowicz, Jarosław Matykiewicz, Anna Dziuba, Justyna Klusek, Łukasz Nawacki, Monika A. Kozłowska-Geller, Wioletta Adamus-Białek, Katarzyna Kubica, Julia Dulębska, Dorota Kozieł, Anna Nasierowska-Guttmejer, Stanisław Głuszek
Publikováno v:
Studia Medyczne, Vol 40, Iss 3, Pp 241-247 (2024)
Externí odkaz:
https://doaj.org/article/98b3ab27a0f64448993e90393ef69d9e
Autor:
Atilio Reyes Romero, Katarzyna Kubica, Radoslaw Kitel, Ismael Rodríguez, Katarzyna Magiera-Mularz, Alexander Dömling, Tad A. Holak, Ewa Surmiak
Publikováno v:
Molecules, Vol 29, Iss 12, p 2926 (2024)
In the published publication [...]
Externí odkaz:
https://doaj.org/article/07c96bba301f4128b33fe3b92feb0447
Autor:
Atilio Reyes Romero, Katarzyna Kubica, Radoslaw Kitel, Ismael Rodríguez, Katarzyna Magiera-Mularz, Alexander Dömling, Tad A. Holak, Ewa Surmiak
Publikováno v:
Molecules, Vol 27, Iss 23, p 8282 (2022)
By binding to the spliceosomal protein Snu66, the human ubiquitin-like protein Hub1 is a modulator of the spliceosome performance and facilitates alternative splicing. Small molecules that bind to Hub1 would be of interest to study the protein-protei
Externí odkaz:
https://doaj.org/article/4d220aacd0f442a4af06fca7242ed41d
Autor:
Katarzyna Kubica
Publikováno v:
Ogrody Nauk i Sztuk. 1:13-142
brak
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::481ff0f9a470cae005d7cbae43b6a28c
https://doi.org/10.15503/onis2011.131.142
https://doi.org/10.15503/onis2011.131.142
Autor:
Justyna Kalinowska-Tluscik, Bogdan Musielak, Katarzyna Kubica, Jan Potempa, Mateusz Jabłoński, Tad A. Holak, Grzegorz Dubin, Marcin Tomala, Krzysztof M. Zak, Aleksandra Twarda-Clapa, Mariusz Madej, Przemyslaw Grudnik, Ewa Surmiak, Alexander Dömling
Publikováno v:
ACS chemical biology, 11(12), 3310-3318. AMER CHEMICAL SOC
The p53 pathway is inactivated in almost all types of cancer by mutations in the p53 encoding gene or overexpression of the p53 negative regulators, Mdm2 and/or Mdmx. Restoration of the p53 function by inhibition of the p53-Mdm2/Mdmx interaction open
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c7197dc7ca994e4f3da5636577a6a2c
https://doi.org/10.1021/acschembio.6b00596
https://doi.org/10.1021/acschembio.6b00596
Autor:
Natalia Estrada-Ortiz, Eberhardt Herdtweck, Kan Wang, Aleksandra Twarda, Alexander Dömling, Constantinos G. Neochoritis, Katarzyna Kubica, Krzysztof M. Zak, Tad A. Holak
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:5661-5666
The protein–protein interaction of p53 and MDM2/X is a promising non genotoxic anticancer target. A rapid and efficient methodology was developed to synthesize the 2,3′-bis(1′H-indole) heterocyclic scaffold 2 as ester, acid and amide derivative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94a49cb2fb67af16891296bb78ba0b18
https://doi.org/10.1016/j.bmcl.2015.11.019
https://doi.org/10.1016/j.bmcl.2015.11.019
Autor:
Bartosz J. Zieba, Grzegorz Dubin, Michael Sattler, Marcin Tomala, Lukasz Skalniak, Katarzyna Magiera-Mularz, Sylwia Krzanik, Tad A. Holak, Bogdan Musielak, Marcin Pustula, Grzegorz M. Popowicz, Katarzyna Kubica
Publikováno v:
Eur. J. Med. Chem. 150, 261-267 (2018)
USP2a is a deubiquitinating protease that rescues its target proteins from destruction by the proteasome by reversing the process of protein ubiquitination. USP2a shows oncogenic properties in vivo and has been found to be a specific activator of cyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1098ce0b05127450a2f7b2d8cff57211
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=53237
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=53237
Autor:
Alexander Dömling, Katarzyna Kubica, Beata Labuzek, Constantinos G. Neochoritis, Katarzyna Guzik, Lukasz Skalniak, Sylwia Krzanik, Kaja Kowalska, Kareem Khoury, Tad A. Holak, Aleksandra Twarda-Clapa, Grzegorz Dubin, Miroslawa Czub
Publikováno v:
Journal of Medicinal Chemistry, 60(10), 4234-4244. AMER CHEMICAL SOC
The tumor suppressor protein p53, the "guardian of the genome", is inactivated in nearly all cancer types by mutations in the TP53 gene or by overexpression of its negative regulators, oncoproteins MDM2/MDMX. Recovery of p53 function by disrupting th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c47043f06a943cfec399b43cc4ce582f
https://pubmed.ncbi.nlm.nih.gov/28482147
https://pubmed.ncbi.nlm.nih.gov/28482147
Autor:
Constantinos G, Neochoritis, Kan, Wang, Natalia, Estrada-Ortiz, Eberhardt, Herdtweck, Katarzyna, Kubica, Aleksandra, Twarda, Krzysztof M, Zak, Tad A, Holak, Alexander, Dömling
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(24)
The protein-protein interaction of p53 and MDM2/X is a promising non genotoxic anticancer target. A rapid and efficient methodology was developed to synthesize the 2,3'-bis(1'H-indole) heterocyclic scaffold 2 as ester, acid and amide derivatives. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7f9819fc93c8a2d076018e749dc8ac9a
https://pubmed.ncbi.nlm.nih.gov/26584879
https://pubmed.ncbi.nlm.nih.gov/26584879
Autor:
Katarzyna Kubica, Marcin Les, Marcin Tomala, Neli Kachamakova-Trojanowska, Bartosz J. Zieba, Katarzyna Magiera, Tad A. Holak, Lukasz Skalniak, Virginia De Cesare, Grzegorz Dubin, Matthias Trost
Publikováno v:
Cell Chemical Biology. 24:458-470.e18
USP2a is a deubiquitinase responsible for stabilization of cyclin D1, a crucial regulator of cell-cycle progression and a proto-oncoprotein overexpressed in numerous cancer types. Here we report that lithocholic acid (LCA) derivatives are inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d43147e41ad651b4abb5939fcd379b9
https://doi.org/10.1016/j.chembiol.2017.03.002
https://doi.org/10.1016/j.chembiol.2017.03.002