Výsledky vyhledávání - "Katarzyna Kempińska"

Akademický článek

Anti-GD2 induced allodynia in rats can be reduced by pretreatment with DFMO.

Autor: Mitchell B Diccianni, Katarzyna Kempińska, Jon A Gangoti, Alice L Yu, Linda S Sorkin

Publikováno v: PLoS ONE, Vol 15, Iss 7, p e0236115 (2020)

BackgroundAnti-GD2 therapy with dinutuximab is effective in improving the survival of high-risk neuroblastoma patients in remission and after relapse. However, allodynia is the major dose-limiting side effect, hindering its use for neuroblastoma pati

Externí odkaz: https://doaj.org/article/5de29d060d224f6c912d99ee93ba3577

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Akademický článek

Synthesis, Structure and Cytotoxic Activity of New Acetylenic Derivatives of Betulin

Autor: Maria Nowak, Maria Jastrzębska, Joachim Kusz, Katarzyna Kempińska, Joanna Wietrzyk, Stanisław Boryczka, Ewa Bębenek

Publikováno v: Molecules, Vol 18, Iss 4, Pp 4526-4543 (2013)

A new series of betulin derivatives containing one or two pharmacophores bearing an acetylenic and carbonyl function at the C-3 and/or C-28 positions has been synthesized and characterized by 1H- and 13C-NMR, IR, MS and elemental analyses. The crysta

Externí odkaz: https://doaj.org/article/7ef4216c31d742529b4bc69b9b8504ce

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Akademický článek

Oral Administration of Polymyxin B Modulates the Activity of Lipooligosaccharide E. coli B against Lung Metastases in Murine Tumor Models.

Autor: Jagoda Kicielińska, Agnieszka Szczygieł, Joanna Rossowska, Natalia Anger, Katarzyna Kempińska, Marta Świtalska, Marta Kaszowska, Joanna Wietrzyk, Janusz Boratyński, Elżbieta Pajtasz-Piasecka

Publikováno v: PLoS ONE, Vol 11, Iss 2, p e0148156 (2016)

INTRODUCTION:Polymyxin B (PmB) belongs to the group of cyclic peptide antibiotics, which neutralize the activity of LPS by binding to lipid A. The aim of this study was to analyze the effect of PmB on the biological activity of lipooligosaccharide (L

Externí odkaz: https://doaj.org/article/cee798ca3ea549fb856c53bd9664243a

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Covalent inhibition of NSD1 histone methyltransferase

Publikováno v: Nature Chemical Biology. 16:1403-1410

The nuclear receptor-binding SET domain (NSD) family of histone methyltransferases is associated with various malignancies, including aggressive acute leukemia with NUP98-NSD1 translocation. While NSD proteins represent attractive drug targets, their

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b50ddaa9b49c0f149319c06274c09039
https://doi.org/10.1038/s41589-020-0626-6

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Comparison of bead array and glass nanoreactor multi-analyte platforms for the evaluation of CNS and peripheral inflammatory markers during HIV infection

Autor: Mitchell B. Diccianni, Ronald J. Ellis, Michael Potter, Scott Letendre, Minh Ly Nguyen, Katarzyna Kempińska, Albert M. Anderson, Debra Rosario

Publikováno v: Anderson, Albert M; Nguyen, Minh Ly; Potter, Michael; Rosario, Debra; Kempinska, Katarzyna; Ellis, Ronald J; et al.(2018). Comparison of bead array and glass nanoreactor multi-analyte platforms for the evaluation of CNS and peripheral inflammatory markers during HIV infection.. Journal of immunological methods. doi: 10.1016/j.jim.2018.11.008. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/0wj8s576

While human immunodeficiency virus (HIV) infection has become a treatable disease with the development of combination antiretroviral therapy (cART), chronic inflammation that affects the central nervous system and other organs is still common. Reliab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b290fae6505cacc581a07aee2103e40
https://doi.org/10.1016/j.jim.2018.11.008

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Akademický článek

Efficient human breast cancer xenograft regression after a single treatment with a novel liposomal formulation of epirubicin prepared using the EDTA ion gradient method.

Autor: Jerzy Gubernator, Dominik Lipka, Mariola Korycińska, Katarzyna Kempińska, Magdalena Milczarek, Joanna Wietrzyk, Rafał Hrynyk, Sabine Barnert, Regine Süss, Arkadiusz Kozubek

Publikováno v: PLoS ONE, Vol 9, Iss 3, p e91487 (2014)

Liposomes act as efficient drug carriers. Recently, epirubicin (EPI) formulation was developed using a novel EDTA ion gradient method for drug encapsulation. This formulation displayed very good stability and drug retention in vitro in a two-year lon

Externí odkaz: https://doaj.org/article/6ed88cd774154c58842be34e310f3b09

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Anti-GD2 induced allodynia in rats can be reduced by pretreatment with DFMO

Autor: Alice L. Yu, Mitchell B. Diccianni, Katarzyna Kempińska, Jon A. Gangoti, Linda S. Sorkin

Publikováno v: PLoS ONE
PloS one, vol 15, iss 7
PLoS ONE, Vol 15, Iss 7, p e0236115 (2020)

Author(s): Diccianni, Mitchell B; Kempinska, Katarzyna; Gangoti, Jon A; Yu, Alice L; Sorkin, Linda S | Abstract: BackgroundAnti-GD2 therapy with dinutuximab is effective in improving the survival of high-risk neuroblastoma patients in remission and a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c885afabe3a80b6378f82f8c7c1ef4a2
http://europepmc.org/articles/PMC7375533

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Pharmacologic Inhibition of the Menin–MLL Interaction Leads to Transcriptional Repression of PEG10 and Blocks Hepatocellular Carcinoma

Autor: Shirish Shukla, Dmitry Borkin, Bhavna Malik, Tomasz Cierpicki, Jingya Wang, Katarzyna Kempińska, Szymon Klossowski, Jolanta Grembecka, Hongzhi Miao

Publikováno v: Molecular Cancer Therapeutics. 17:26-38

Hepatocellular carcinoma (HCC) accounts for approximately 85% of malignant liver tumors and results in 600,000 deaths each year, emphasizing the need for new therapies. Upregulation of menin was reported in HCC patients and high levels of menin corre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b43c9c76289d9b4e147e89245635348f
https://doi.org/10.1158/1535-7163.mct-17-0580

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N-Arylaminomethylenebisphosphonates Bearing Fluorine Atoms: Synthesis and Antiosteoporotic Activity

Autor: Zuzanna Mazur, Katarzyna Kempińska, Joanna Wietrzyk, Anita Piątek, Paweł Kafarski, Jan Kuryszko, Zdzisław Kiełbowicz, Ewa Chmielewska

Publikováno v: Phosphorus, Sulfur, and Silicon and the Related Elements. 190:2164-2172

A series of N-phenyl and N-pyridyl-aminomethylenebisphosphonates substituted in their aromatic rings with fluorine atoms or trifluoromethyl groups have been synthesized by a three component approach. They were screened for potential antiosteoporetic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f745a4e9b2bd3043315648d580e10c49
https://doi.org/10.1080/10426507.2015.1085046

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