Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Katarzyna Gach-Janczak"'
Autor:
Anna Laskowska, Agata J. Pacuła-Miszewska, Magdalena Obieziurska-Fabisiak, Aneta Jastrzębska, Angelika Długosz-Pokorska, Katarzyna Gach-Janczak, Jacek Ścianowski
Publikováno v:
Molecules, Vol 29, Iss 12, p 2866 (2024)
A series of phenyl β-carbonyl selenides with o-ester functionality substituted on the oxygen atom with chiral and achiral alkyl groups was synthesized. All compounds are the first examples of this type of organoselenium derivatives with an ester sub
Externí odkaz:
https://doaj.org/article/5218e63f94214e17bdf16bc3d92229a9
Autor:
Katarzyna Gach-Janczak, Monika Biernat, Mariola Kuczer, Anna Adamska-Bartłomiejczyk, Alicja Kluczyk
Publikováno v:
Molecules, Vol 29, Iss 7, p 1544 (2024)
Pain affects one-third of the global population and is a significant public health issue. The use of opioid drugs, which are the strongest painkillers, is associated with several side effects, such as tolerance, addiction, overdose, and even death. A
Externí odkaz:
https://doaj.org/article/27b7829e489e4675a8f0a5fc3a37e8f4
Autor:
Anna Laskowska, Agata J. Pacuła-Miszewska, Magdalena Obieziurska-Fabisiak, Aneta Jastrzębska, Angelika Długosz-Pokorska, Katarzyna Gach-Janczak, Jacek Ścianowski
Publikováno v:
Materials, Vol 17, Iss 4, p 899 (2024)
A series of unsymmetrical phenyl β-carbonyl selenides with o-amido function substituted on the nitrogen atom with chiral alkyl groups was obtained. The compounds form a series of enantiomeric and diastereomeric pairs and present the first examples o
Externí odkaz:
https://doaj.org/article/495b6bdf8960448a9f6e2bd25885726c
Autor:
Agata J. Pacuła-Miszewska, Magdalena Obieziurska-Fabisiak, Aneta Jastrzębska, Angelika Długosz-Pokorska, Katarzyna Gach-Janczak, Jacek Ścianowski
Publikováno v:
Pharmaceuticals, Vol 16, Iss 11, p 1560 (2023)
Organoselenium compounds are well-known for their numerous biocapacities, which result from the uniqueness of the selenium atom and the possibility of constructing heterorganic molecules that can mimic the activity of selenoenzymes, crucial for a mul
Externí odkaz:
https://doaj.org/article/d91228dcfd3a4535a238ddd8c50d02c0
Autor:
Joanna Drogosz-Stachowicz, Katarzyna Gach-Janczak, Marek Mirowski, Jacek Pietrzak, Tomasz Janecki, Anna Janecka
Publikováno v:
Molecules, Vol 28, Iss 7, p 3128 (2023)
Herein, the antitumor activity of a novel synthetic analog with 5,8-quinolinedione scaffold, diethyl (2-(2-chlorophenyl)-4,9-dioxo-4,9-dihydrofuro [3,2-g]quinolin-3-yl)phosphonate (AJ-418) was investigated on two breast cancer cell lines. This analog
Externí odkaz:
https://doaj.org/article/3918a371015b4ba29fd1d27a76d5c384
Autor:
Anna Kowalczyk, Kamil Świątek, Małgorzata Celeda, Greta Utecht-Jarzyńska, Agata Jaskulska, Katarzyna Gach-Janczak, Marcin Jasiński
Publikováno v:
Materials, Vol 16, Iss 2, p 856 (2023)
The synthesis of two series of monocyclic and bicyclic trifluoromethylated 4,5-dihydro-1,2,4-triazin-6(1H)-one derivatives based on (3+3)-annulation of methyl esters derived from natural α-amino acids with in situ generated trifluoroacetonitrile imi
Externí odkaz:
https://doaj.org/article/6c2b3c1b65204f5d9c683e4039f95bd2
Autor:
Agata Jaskulska, Katarzyna Gach-Janczak, Joanna Drogosz-Stachowicz, Tomasz Janecki, Anna Ewa Janecka
Publikováno v:
Molecules, Vol 27, Iss 11, p 3597 (2022)
Quinolinones have been known for a long time as broad-spectrum synthetic antibiotics. More recently, the anticancer potential of this group of compounds has been investigated. Following this direction, we obtained a small library of 3-methylidene-1-s
Externí odkaz:
https://doaj.org/article/94337694d0cb46bbb209093b0c199742
Autor:
Tomasz Bartosik, Joanna Drogosz-Stachowicz, Anna Janecka, Jacek Kędzia, Barbara Pacholczyk-Sienicka, Jacek Szymański, Katarzyna Gach-Janczak, Tomasz Janecki
Publikováno v:
Materials, Vol 15, Iss 9, p 3030 (2022)
In this report, we present efficient and stereoselective syntheses of 2,6-disubstituted trans-3-methylidenetetrahydropyran-4-ones and 2-(4-methoxyphenyl)-5-methylidenetetrahydropyran-4-one that significantly broaden the spectrum of the available meth
Externí odkaz:
https://doaj.org/article/7b966a93bbb249609d30667441d0dbb2
Autor:
Anna Laskowska, Agata J. Pacuła-Miszewska, Magdalena Obieziurska-Fabisiak, Aneta Jastrzębska, Katarzyna Gach-Janczak, Anna Janecka, Jacek Ścianowski
Publikováno v:
RSC Advances. 13:14698-14702
The evaluation of antioxidant and anticancer properties of newly synthesized chiral phenylselenides revealed promising N-indanyl derivatives.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9209c7e5d63bc7207207b9be6db383e9
https://doi.org/10.1039/d3ra02475j
https://doi.org/10.1039/d3ra02475j
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 1, p 4 (2020)
A sesquiterpene lactone, thapsigargin, is a phytochemical found in the roots and fruits of Mediterranean plants from Thapsia L. species that have been used for centuries in folk medicine to treat rheumatic pain, lung diseases, and female infertility.
Externí odkaz:
https://doaj.org/article/99bbd25b6a48458e82e8c88fe3fe0722