Synthesis of a New Class of β-Carbonyl Selenides Functionalized with Ester Groups with Antioxidant and Anticancer Properties—Part II

Autor: Anna Laskowska, Agata J. Pacuła-Miszewska, Magdalena Obieziurska-Fabisiak, Aneta Jastrzębska, Angelika Długosz-Pokorska, Katarzyna Gach-Janczak, Jacek Ścianowski

Publikováno v: Molecules, Vol 29, Iss 12, p 2866 (2024)

A series of phenyl β-carbonyl selenides with o-ester functionality substituted on the oxygen atom with chiral and achiral alkyl groups was synthesized. All compounds are the first examples of this type of organoselenium derivatives with an ester sub

Externí odkaz: https://doaj.org/article/5218e63f94214e17bdf16bc3d92229a9

The Influence of Long Carbon Chains on the Antioxidant and Anticancer Properties of N-Substituted Benzisoselenazolones and Corresponding Diselenides

Autor: Agata J. Pacuła-Miszewska, Magdalena Obieziurska-Fabisiak, Aneta Jastrzębska, Angelika Długosz-Pokorska, Katarzyna Gach-Janczak, Jacek Ścianowski

Publikováno v: Pharmaceuticals, Vol 16, Iss 11, p 1560 (2023)

Organoselenium compounds are well-known for their numerous biocapacities, which result from the uniqueness of the selenium atom and the possibility of constructing heterorganic molecules that can mimic the activity of selenoenzymes, crucial for a mul

Externí odkaz: https://doaj.org/article/d91228dcfd3a4535a238ddd8c50d02c0

Synthesis and Anticancer Properties of New 3-Methylidene-1-sulfonyl-2,3-dihydroquinolin-4(1H)-ones

Autor: Agata Jaskulska, Katarzyna Gach-Janczak, Joanna Drogosz-Stachowicz, Tomasz Janecki, Anna Ewa Janecka

Publikováno v: Molecules, Vol 27, Iss 11, p 3597 (2022)

Quinolinones have been known for a long time as broad-spectrum synthetic antibiotics. More recently, the anticancer potential of this group of compounds has been investigated. Following this direction, we obtained a small library of 3-methylidene-1-s

Externí odkaz: https://doaj.org/article/94337694d0cb46bbb209093b0c199742

A New Hybrid δ-Lactone Induces Apoptosis and Potentiates Anticancer Activity of Taxol in HL-60 Human Leukemia Cells

Autor: Katarzyna Gach-Janczak, Joanna Drogosz-Stachowicz, Angelika Długosz-Pokorska, Rafał Jakubowski, Tomasz Janecki, Jacek Szymański, Anna Janecka

Publikováno v: Molecules, Vol 25, Iss 7, p 1479 (2020)

In the search for new drug candidates, researchers turn to natural substances isolated from plants which may be either used directly or may serve as a source for chemical modifications. An interesting strategy in the design of novel anticancer agents

Externí odkaz: https://doaj.org/article/e057b219b9af4f31add579300f8945b4

The Gliopeptide ODN, a Ligand for the Benzodiazepine Site of GABAA Receptors, Boosts Functional Recovery after Stroke

Autor: Julien Chuquet, Andrew N. Clarkson, Ann-Britt Marcher, Katarzyna Gach-Janczak, Mahmoud Hazime, David Vaudry, Julie Maucotel, Katia Lehongre, Benjamin Lefranc, Pascale P. Quilichini, Raghavendra Y. Nagaraja, Emma K. Gowing, Susanne Mandrup, Rhita Lamtahri, Jérôme Leprince, Michael Alasoadura

Publikováno v: Lamtahri, R, Hazime, M, Gowing, E K, Nagaraja, R Y, Maucotel, J, Alasoadura, M, Quilichini, P P, Lehongre, K, Lefranc, B, Gach-Janczak, K, Marcher, A B, Mandrup, S, Vaudry, D, Clarkson, A N, Leprince, J & Chuquet, J 2021, ' The gliopeptide ODN, a ligand for the benzodiazepine site of GABA A receptors, boosts functional recovery after stroke ', Journal of Neuroscience, vol. 41, no. 33, pp. 7148-7159 . https://doi.org/10.1523/JNEUROSCI.2255-20.2021
Journal of Neuroscience
Journal of Neuroscience, 2021, 41 (33), pp.7148-7159. ⟨10.1523/JNEUROSCI.2255-20.2021⟩

Following stroke, the survival of neurons and their ability to re-establish connections is critical to functional recovery. This is strongly influenced by the balance between neuronal excitation and inhibition. In the acute phase of experimental stro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25649e49dc0582c0ff69b132fd0af09a
https://doi.org/10.1523/jneurosci.2255-20.2021