Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Katarzyna Bielawska"'
Autor:
Thi Yen Ly Huynh, Ilona Oscilowska, Lukasz Szoka, Ewelina Piktel, Weronika Baszanowska, Katarzyna Bielawska, Robert Bucki, Wojciech Miltyk, Jerzy Palka
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Although the antineoplastic activity of metformin (MET) is well established, the underlying mechanism of the activity is not understood. Since MET activates AMP kinase (AMPK) and proline dehydrogenase/proline oxidase (PRODH/POX) is stimulated by AMPK
Externí odkaz:
https://doaj.org/article/a7309ecbd66c440ea52e6efff7a95d36
Publikováno v:
Diagnostics, Vol 12, Iss 9, p 2137 (2022)
Colorectal cancer (CRC) is a common and mortal disease. Chronic kidney disease (CKD) is the relatively common comorbidity among cancer patients affecting the available therapy and outcomes. However, data on prevalence of CKD in patients with CRC unde
Externí odkaz:
https://doaj.org/article/1831fa0e8e3f4750909d499c5bcc2d67
Autor:
Karolina Lendzion, Agnieszka Gornowicz, Jakub W. Strawa, Katarzyna Bielawska, Robert Czarnomysy, Bożena Popławska, Krzysztof Bielawski, Michał Tomczyk, Wojciech Miltyk, Anna Bielawska
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 11584 (2022)
Scorzonera hispanica is an herbaceous perennial cultivated in Central and Southern Europe. This study aimed to qualitatively and quantitatively evaluate the composition of oil, extracts, and fractions (SH1-SH12) obtained from S. hispanica seeds. Furt
Externí odkaz:
https://doaj.org/article/4f807e0e40494e35a67e89d4d095ed6e
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 7, p 3813 (2022)
Non-steroidal anti-inflammatory drugs (NSAIDs) are considered in cancer therapy for their inhibitory effect on cyclooxygenase-2 (COX-2), which is overexpressed in most cancers. However, we found that NSAIDs as ligands of peroxisome proliferator-activ
Externí odkaz:
https://doaj.org/article/295d58a5fd6d4df49e2b889794299a7d
Autor:
Ilona Oscilowska, Karol Rolkowski, Weronika Baszanowska, Thi Yen Ly Huynh, Sylwia Lewoniewska, Magdalena Nizioł, Magdalena Sawicka, Katarzyna Bielawska, Paweł Szoka, Wojciech Miltyk, Jerzy Palka
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 4, p 2354 (2022)
The role of proline dehydrogenase/proline oxidase (PRODH/POX) in the mechanism of antineoplastic activity of metformin (MET) was studied in C32 melanoma cells. PRODH/POX is a mitochondrial enzyme-degrading proline that is implicated in the regulation
Externí odkaz:
https://doaj.org/article/b4eb6d2c75054e1cbde069f7d8dc6c5c
Autor:
Michał Biernacki, Ewa Ambrożewicz, Agnieszka Gęgotek, Marek Toczek, Katarzyna Bielawska, Elżbieta Skrzydlewska
Publikováno v:
Redox Biology, Vol 15, Iss C, Pp 41-50 (2018)
Primary and secondary hypertension is associated with kidney redox imbalance resulting in enhanced reactive oxygen species (ROS) and enzymes dependent phospholipid metabolism. The fatty acid amide hydrolase inhibitor, URB597, modulates the levels of
Externí odkaz:
https://doaj.org/article/9ce08ffca2f84b6b840889738dbe39f5
Publikováno v:
Pharmaceuticals, Vol 14, Iss 9, p 874 (2021)
Celecoxib (Cx), an inhibitor of cyclooxygenase 2, induces apoptosis of cancer cells. However, the mechanism of the chemopreventive effect remains not fully understood. We aimed to investigate the role of PRODH/POX that is involved in the regulation o
Externí odkaz:
https://doaj.org/article/5dc997edb28a456b9dccf55e31bc5d04
Autor:
Agnieszka Gęgotek, Katarzyna Bielawska, Michał Biernacki, Izabela Dobrzyńska, Elżbieta Skrzydlewska
Publikováno v:
Redox Biology, Vol 12, Iss , Pp 733-744 (2017)
Chronic exposure of the skin to solar UV radiation induces a number of biological alterations, including a redox imbalance; therefore, there is an urgent need for skin cells protective compounds. The aim of this study was to determine the effects of
Externí odkaz:
https://doaj.org/article/75e45492625a4f6ea78a578e29d8c798
Publikováno v:
Antioxidants, Vol 7, Iss 8, p 108 (2018)
Evening primrose (Oenothera L.) is a plant belonging to the family Onagraceae, in which the most numerous species is Oenothera biennis. Some plants belonging to the genus Oenothera L. are characterized by biological activity. Therefore, studies were
Externí odkaz:
https://doaj.org/article/e2cf62cfe12946bca630e4c8e50686cf
Autor:
Jerzy Pałka, Sylwia Lewoniewska, Izabela Prokop, Weronika Baszanowska, Katarzyna Bielawska, Ilona Oscilowska, Thi Yen Ly Huynh
Publikováno v:
Journal of Clinical Medicine, Vol 10, Iss 4641, p 4641 (2021)
Journal of Clinical Medicine
Journal of Clinical Medicine 2021 10 (20)
Volume 10
Issue 20
Journal of Clinical Medicine
Journal of Clinical Medicine 2021 10 (20)
Volume 10
Issue 20
Simple Summary PRODH/POX (proline dehydrogenase/proline oxidase) is a mitochondrial enzyme that catalyzes proline degradation generating reactive oxygen species (ROS). Estrogens limit proline availability for PRODH/POX by stimulating collagen biosynt