Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Katarzyna Błaszczak-Świątkiewicz"'
Publikováno v:
Molecules, Vol 26, Iss 21, p 6491 (2021)
Receptor activator of nuclear factor κB (RANK) and its ligand (RANKL) play key roles in bone metabolism and the immune system. The RANK/RANKL complex has also been shown to be critical in the formation of mammary epithelia cells. The female hormones
Externí odkaz:
https://doaj.org/article/7b10aaf7ac6e4049a35883c746c27a12
Publikováno v:
Molecules, Vol 25, Iss 6, p 1321 (2020)
Breast cancer depends on women’s age. Its chemotherapy and hormone therapy lead to the loss of bone density and disruption of the skeleton. The proteins RANK and RANKL play a pivotal role in the formation of osteoclasts. It is also well established
Externí odkaz:
https://doaj.org/article/4e2f7c4c272e420bab806ff5cff5a457
Autor:
Michał Szewczuk, Karolina Boguszewska, Marta Żebrowska, Ewa Balcerczak, Marta Stasiak, Maria Świątkowska, Katarzyna Błaszczak-Świątkiewicz
Publikováno v:
Tumor Biology, Vol 39 (2017)
Virus-directed enzyme prodrug therapy is one of the major strategy of increasing cytotoxicity of bioreductive agents. This research intended to examine new selected benzimidazole derivatives as a substrate for nitroreductase, the enzyme involved in n
Externí odkaz:
https://doaj.org/article/1fad81aace6c48c8a1e6aebc2f186d23
Publikováno v:
Molecules, Vol 19, Iss 10, Pp 15361-15373 (2014)
The study presented here is a follow up of the authors’ interest in the approach to selective and cytotoxic bioreductive anticancer prodrugs. The current work is devoted to explore both the biological activity of some previously obtained compounds
Externí odkaz:
https://doaj.org/article/87f6e82c277b47038d3648f3fbf84efa
Antiproliferative Aspect of Benzimidazole Derivatives’ Activity and Their Impact on NF-κB Expression
Publikováno v:
Molecules, Vol 24, Iss 21, p 3902 (2019)
Benzimidazoles belong to a new class of bioreductive agents with cytotoxic activity towards solid tumor cells, especially in their first stage of growth, which is characterized by low oxygen concentration. Bioreductive agents represent a class of pro
Externí odkaz:
https://doaj.org/article/97254e40b8d546949dd649adaedc76a6
Autor:
Katarzyna Błaszczak-Świątkiewicz, Diogo Correia Almeida, Maria De Jesus Perry, Elżbieta Mikiciuk-Olasik
Publikováno v:
Molecules, Vol 19, Iss 1, Pp 400-413 (2013)
In this work, a sensitive analytical method to study the stability of two new series of synthesized heterocyclic compounds, the benzimidazole-4,7-diones 5 and N-oxide benzimidazole-4,7-dione derivatives 6 was established and validated. These derivati
Externí odkaz:
https://doaj.org/article/77cb9cd851e643fc8563ed36726fdfb2
Publikováno v:
Molecules, Vol 26, Iss 6491, p 6491 (2021)
Molecules
Molecules
Receptor activator of nuclear factor κB (RANK) and its ligand (RANKL) play key roles in bone metabolism and the immune system. The RANK/RANKL complex has also been shown to be critical in the formation of mammary epithelia cells. The female hormones
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a3890c3a511a7d5c0b801cceca58be1
https://pubmed.ncbi.nlm.nih.gov/34770897
https://pubmed.ncbi.nlm.nih.gov/34770897
Autor:
Joanna Sikora, Elżbieta Mikiciuk-Olasik, Jacek Szymański, Katarzyna Błaszczak-Świątkiewicz, Marian Danilewicz
Publikováno v:
Tumour Biology
In this work, the in vitro tests of biological activity of benzimidazoles were conducted. This group of benzimidazole derivatives was evaluated as potential bioreductive agents and their characteristic pro-apoptosis activity and cell cycle interrupti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e800b85b58271aa681b161c89a8038a7
http://europepmc.org/articles/PMC4999476
http://europepmc.org/articles/PMC4999476
Publikováno v:
Advances in Medical Sciences. 60:125-132
In this work, the biological activity of some benzimidazoles and benzimidazole-4,7-diones was compared. These two groups of compounds were evaluated as potential chemotherapeutics and their characteristic relationship structure to biological activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c789ebb595795142520850f93c8f1a6
https://doi.org/10.1016/j.advms.2015.01.004
https://doi.org/10.1016/j.advms.2015.01.004
Autor:
Ewa Balcerczak, Marta Żebrowska, Karolina Boguszewska, Katarzyna Błaszczak-Świątkiewicz, Maria Świątkowska, Marta Stasiak, Michał Szewczuk
Publikováno v:
Tumor Biology, Vol 39 (2017)
Virus-directed enzyme prodrug therapy is one of the major strategy of increasing cytotoxicity of bioreductive agents. This research intended to examine new selected benzimidazole derivatives as a substrate for nitroreductase, the enzyme involved in n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6de13efd9f41306f4737907e970f5bb
https://doaj.org/article/1fad81aace6c48c8a1e6aebc2f186d23
https://doaj.org/article/1fad81aace6c48c8a1e6aebc2f186d23