Increased hippocampal excitability in miR-324-null mice

Autor: Dan J. Hayman, Tamara Modebadze, Sarah Charlton, Kat Cheung, Jamie Soul, Hua Lin, Yao Hao, Colin G. Miles, Dimitra Tsompani, Robert M. Jackson, Michael D. Briggs, Katarzyna A. Piróg, Ian M. Clark, Matt J. Barter, Gavin J. Clowry, Fiona E. N. LeBeau, David A. Young

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)

Abstract MicroRNAs are non-coding RNAs that act to downregulate the expression of target genes by translational repression and degradation of messenger RNA molecules. Individual microRNAs have the ability to specifically target a wide array of gene t

Externí odkaz: https://doaj.org/article/b74a1a1210eb465eb49f8ba80fb52c10

Calcium activated nucleotidase 1 (CANT1) is critical for glycosaminoglycan biosynthesis in cartilage and endochondral ossification

Autor: Katarzyna A. Piróg, Valérie Cormier-Daire, Céline Huber, Silvia Lecci, Luca Monti, Jean-Marc Schwartz, Marco Biggiogera, Beth G Gibson, Rossella Costantini, Kun Tian, Chiara Paganini, Roberta Besio, Antonio Rossi, Antonella Forlino

Publikováno v: Paganini, C, Monti, L, Costantini, R, Besio, R, Lecci, S, Biggiogera, M, Tian, K, Schwartz, J-M, Huber, C, Cormier-Daire, V, Gibson, B G, Pirog, K A, Forlino, A & Rossi, A 2019, ' Calcium activated nucleotidase 1 (CANT1) is critical for glycosaminoglycan biosynthesis in cartilage and endochondral ossification ', Matrix biology : journal of the International Society for Matrix Biology, vol. 81, pp. 70-90 . https://doi.org/10.1016/j.matbio.2018.11.002
Matrix Biology

Desbuquois dysplasia type 1 (DBQD1) is a chondrodysplasia caused by mutations in CANT1 gene encoding an ER/Golgi calcium activated nucleotidase 1 that hydrolyses UDP. Here, using Cant1 knock-in and knock-out mice recapitulating DBQD1 phenotype, we re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::923cf9ea36f36b0f7855db955f3440ad
https://doi.org/10.1016/j.matbio.2018.11.002

Increased hippocampal excitability in miR-324-null mice

Autor: Michael D. Briggs, Robert M. Jackson, Dimitra Tsompani, Yao Hao, Katarzyna A. Piróg, Tamara Modebadze, Jamie Soul, Gavin J. Clowry, David Young, Fiona E. N. LeBeau, Sarah Charlton, Colin G. Miles, Ian M. Clark, Dan J. Hayman, Kathleen Cheung, Hua Lin, Matt J. Barter

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Scientific Reports

MicroRNAs are non-coding RNAs that act to downregulate the expression of target genes by translational repression and degradation of messenger RNA molecules. Individual microRNAs have the ability to specifically target a wide array of gene transcript

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d418215007155d56e894db76e03d3933
https://ueaeprints.uea.ac.uk/id/eprint/80121/

Author response for 'CRELD2 is a novel LRP1 chaperone that regulates non‐canonical WNT signalling in skeletal development'

Autor: Sarah M. Edwards, Michael D. Briggs, Claire L. Hartley, Raymond P. Boot‐Handford, Dimitra Tsompani, Anna Teti, Katarzyna A. Piróg, Mattia Capulli, Robert M. Jackson, Ella P. Dennis, David Young

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::67ed5d1a102a484308de6358d3f8e380
https://doi.org/10.1002/jbmr.4010/v2/response1

microRNA-seq of cartilage reveals an over-abundance of miR-140-3p which contains functional isomiRs

Autor: Katarzyna A. Piróg, Robert M. Jackson, Tamas Dalmay, Matt J. Barter, Dimitra Tsompani, Sarah Charlton, Andrew J. Skelton, David Young, Kathleen Cheung, Tracey E. Swingler, Jamie Soul, Ian M. Clark, Louise N. Reynard, N. Crowe, Yao Hao, Steven Woods, Colin G. Miles

Publikováno v: Woods, S, Charlton, S, Cheung, K, Hao, Y, Soul, J, Reynard, L N, Crowe, N, Swingler, T E, Skelton, A J, Piróg, K A, Miles, C G, Tsompani, D, Jackson, R M, Dalmay, T, Clark, I M, Barter, M J & Young, D A 2020, ' microRNA-seq of cartilage reveals an over-abundance of miR-140-3p which contains functional isomiRs ', RNA (New York, N.Y.) . https://doi.org/10.1261/rna.075176.120
RNA

MiR-140 is selectively expressed in cartilage. Deletion of the entire miR-140 locus in mice results in growth retardation and early-onset osteoarthritis-like pathology, however the relative contribution of miR-140-5p or miR-140-3p to the phenotype re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::640a49e1e7871988538477c18d056f34
https://www.research.manchester.ac.uk/portal/en/publications/micrornaseq-of-cartilage-reveals-an-overabundance-of-mir1403p-which-contains-functional-isomirs(25abf5c9-f846-4858-b0ae-09f5d2f6babb).html