Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Katarzyna Świderek"'
Autor:
Francisco J. Medrano, Sergio de la Hoz-Rodríguez, Sergio Martí, Kemel Arafet, Tanja Schirmeister, Stefan J. Hammerschmidt, Christin Müller, Águeda González-Martínez, Elena Santillana, John Ziebuhr, Antonio Romero, Collin Zimmer, Annabelle Weldert, Robert Zimmermann, Alessio Lodola, Katarzyna Świderek, Vicent Moliner, Florenci V. González
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract The coronavirus disease 2019 (COVID-19) pandemic continues to represent a global public health issue. The viral main protease (Mpro) represents one of the most attractive targets for the development of antiviral drugs. Herein we report pepti
Externí odkaz:
https://doaj.org/article/3ea31cb9aaef4184b8998a4dd4345a66
Autor:
Elena Gabirondo, Katarzyna Świderek, Edurne Marin, Ainhoa Maiz‐Iginitz, Aitor Larranaga, Vicent Moliner, Agustin Etxeberria, Haritz Sardon
Publikováno v:
Advanced Science, Vol 11, Iss 16, Pp n/a-n/a (2024)
Abstract Amino acids are indispensable compounds in the body, performing several biological processes that enable proper functioning. In this work, it is demonstrated that a single amino acid, taurine, is also able to promote the ring‐opening polym
Externí odkaz:
https://doaj.org/article/1b6f133c258547ee8de30319225e5453
Autor:
Katarzyna Świderek, Susana Velasco-Lozano, Miquel À. Galmés, Ion Olazabal, Haritz Sardon, Fernando López-Gallego, Vicent Moliner
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Biocatalysis is a key technology enabling plastic recycling. However, despite advances done in the development of plastic-degrading enzymes, the molecular mechanisms that govern their catalytic performance are poorly understood, hampering th
Externí odkaz:
https://doaj.org/article/cec1a30d701d4fe89d027e8162a31bb2
Publikováno v:
Pharmaceuticals, Vol 15, Iss 5, p 531 (2022)
20S proteasome is a main player in the protein degradation pathway in the cytosol, thus intervening in multiple pivotal cellular processes. Over the years the proteasome has emerged as a crucial target for the treatment of many diseases such as neuro
Externí odkaz:
https://doaj.org/article/d47f7efd78c04f66bf123ea30a650400
Publikováno v:
ACS Omega, Vol 3, Iss 12, Pp 18613-18622 (2018)
Externí odkaz:
https://doaj.org/article/2380bc2330764f62980af19140f768b3
Autor:
Weiwu Ren, Robert Pengelly, Marco Farren-Dai, Saeideh Shamsi Kazem Abadi, Verena Oehler, Oluwafemi Akintola, Jason Draper, Michael Meanwell, Saswati Chakladar, Katarzyna Świderek, Vicent Moliner, Robert Britton, Tracey M. Gloster, Andrew J. Bennet
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Mechanism-based inhibitors of glycoside hydrolases are useful probes for basic research and represent potential drug candidates. Here, the authors present a series of mechanism-based covalent α-galactosidase inhibitors and elucidate the kinetic and
Externí odkaz:
https://doaj.org/article/744697e101804594badef9eae41b0671
Publikováno v:
Frontiers in Chemistry, Vol 6 (2019)
This work is focused on mechanistic studies of the transfer of an adenylyl group (Adenoside-5′-monophosfate) from adenosine 5′-triphosphate (ATP) to a OH-4′ hydroxyl group of an antibiotic. Using hybrid quantum mechanics/molecular mechanics (QM
Externí odkaz:
https://doaj.org/article/22c0140b8bc6440fade62ede61df8e64
Publikováno v:
Molecules, Vol 20, Iss 10, Pp 17789-17806 (2015)
Candida Antarctica lipase B (CALB) is a well-known enzyme, especially because of its promiscuous activity. Due to its properties, CALB was widely used as a benchmark for designing new catalysts for important organic reactions. The active site of CALB
Externí odkaz:
https://doaj.org/article/cf4b12b9443d46a2a4c0cb885267d58f
Autor:
Sandra G. Zárate, Paula Morales, Katarzyna Świderek, Victor M. Bolanos-Garcia, Agatha Bastida
Publikováno v:
Antibiotics, Vol 8, Iss 1, p 25 (2019)
Multidrug efflux systems play a prominent role in medicine, as they are important contributors to bacterial antibiotic resistance. NorA is an efflux pump transporter from the major facilitator superfamily that expels numerous drug compounds across th
Externí odkaz:
https://doaj.org/article/32127b8a83464541a639d2ec46f7b8ea
Autor:
Weiwu Ren, Robert Pengelly, Marco Farren-Dai, Saeideh Shamsi Kazem Abadi, Verena Oehler, Oluwafemi Akintola, Jason Draper, Michael Meanwell, Saswati Chakladar, Katarzyna Świderek, Vicent Moliner, Robert Britton, Tracey M. Gloster, Andrew J. Bennet
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
In the originally published version of this Article, the affiliation details for Tracey M. Gloster were incorrectly given as 'Department of Molecular Biology and Biochemistry, Simon Fraser University, 8888 University Drive, Burnaby, BC V5A 1S6, Canad
Externí odkaz:
https://doaj.org/article/1df1caa3778044208b7040f3cf07d019