Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Katarzyna, Kazmierczak"'
Autor:
Yoel H. Sitbon, Katarzyna Kazmierczak, Jingsheng Liang, Andrew J. Kloehn, Judith Vinod, Rosemeire Kanashiro-Takeuchi, Danuta Szczesna-Cordary
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110591- (2024)
Summary: We investigated the role of the N-terminus (residues 1–43) of the myosin essential light chain (N-ELC) in regulating cardiac function in hypertrophic (HCM-A57G) and restrictive (RCM-E143K) cardiomyopathy mice. Both models were cross-genoty
Externí odkaz:
https://doaj.org/article/db0fb018c04f49009768f6ee88a379bb
Autor:
Marta Jokiel, Katarzyna Kazmierczak, Piotr Czarnecki, Aleksandra Bartkowiak-Graczyk, Anna Madziewicz, Ewa Breborowicz, Malgorzata Miedzyblocka, Michal Adamski, Krystian Kaczmarek, Leszek Kaczmarek, Leszek Romanowski
Publikováno v:
Medicina, Vol 60, Iss 7, p 1184 (2024)
Background and Objectives: Biodex System® is an advanced dynamometer used for testing various biomechanical parameters of muscles. Test outcomes allow for the identification of muscle pathology and consequently lead to a clinical diagnosis. Despite
Externí odkaz:
https://doaj.org/article/b600d80d7e954194935c57f462702398
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
In this study, we investigated the rescue potential of two phosphomimetic mutants of the myosin regulatory light chain (RLC, MYL2 gene), S15D, and T160D RLCs. S15D-RLC mimics phosphorylation of the established serine-15 site of the human cardiac RLC.
Externí odkaz:
https://doaj.org/article/0b6687a89c08428fa5f71a68224092d1
Autor:
Katarzyna Kazmierczak, Jingsheng Liang, Luis G. Maura, Natissa K. Scott, Danuta Szczesna-Cordary
Publikováno v:
Life, Vol 13, Iss 7, p 1463 (2023)
This study focuses on mimicking constitutive phosphorylation in the N-terminus of the myosin regulatory light chain (S15D-RLC) as a rescue strategy for mutation-induced cardiac dysfunction in transgenic (Tg) models of restrictive (RCM) and dilated (D
Externí odkaz:
https://doaj.org/article/79bba336e1da4e41b2f149b52ed6921e
Autor:
Rosemeire M. Kanashiro-Takeuchi, Katarzyna Kazmierczak, Jingsheng Liang, Lauro M. Takeuchi, Yoel H. Sitbon, Danuta Szczesna-Cordary
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 24, p 15589 (2022)
In this study, we aimed to investigate whether short-term and low-dose treatment with hydroxychloroquine (HCQ), an antimalarial drug, can modulate heart function in a preclinical model of dilated cardiomyopathy (DCM) expressing the D94A mutation in c
Externí odkaz:
https://doaj.org/article/132cbd8fcfcb4b07b75aa5ebbca1b30e
Autor:
Szczesna-Cordary, Katarzyna Kazmierczak, Jingsheng Liang, Luis G. Maura, Natissa K. Scott, Danuta
Publikováno v:
Life; Volume 13; Issue 7; Pages: 1463
This study focuses on mimicking constitutive phosphorylation in the N-terminus of the myosin regulatory light chain (S15D-RLC) as a rescue strategy for mutation-induced cardiac dysfunction in transgenic (Tg) models of restrictive (RCM) and dilated (D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::f6aa58c75fc05679a0e905b7c4833048
Autor:
Yihua Wang, Chen-Ching Yuan, Katarzyna Kazmierczak, Danuta Szczesna-Cordary, Thomas P. Burghardt
Publikováno v:
Open Biology, Vol 8, Iss 4 (2018)
Myosin transduces ATP free energy into mechanical work in muscle. Cardiac muscle has dynamically wide-ranging power demands on the motor as the muscle changes modes in a heartbeat from relaxation, via auxotonic shortening, to isometric contraction. T
Externí odkaz:
https://doaj.org/article/ceb5d5e493df461bba2ab23d2e9ad289
Autor:
Rosemeire M. Kanashiro-Takeuchi, Lauro M. Takeuchi, Raul A. Dulce, Katarzyna Kazmierczak, Wayne Balkan, Renzhi Cai, Wei Sha, Andrew V. Schally, Joshua M. Hare
Heart failure (HF) with preserved ejection fraction (HFpEF) represents a major unmet medical need owing to its diverse pathophysiology and lack of effective therapies. Potent synthetic, agonists (MR-356 and MR409) of growth hormone-releasing hormone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf5eb5724af07ef228e142b868993d34
https://doi.org/10.1101/2022.09.18.508429
https://doi.org/10.1101/2022.09.18.508429
Autor:
Danuta Szczesna-Cordary, Katarzyna Kazmierczak, Masataka Kawai, Li Wang, Yun Hang, Zhang Jiajia
Publikováno v:
The FEBS Journal. 288:4596-4613
We investigated the mechanisms associated with E22K mutation in myosin regulatory light chain (RLC), found to cause hypertrophic cardiomyopathy (HCM) in humans and mice. Specifically, we characterized the mechanical profiles of papillary muscle fiber
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a05f63e7c3c31c681562bf4eb0653c39
https://doi.org/10.1111/febs.15753
https://doi.org/10.1111/febs.15753
Autor:
Bertrand C.W. Tanner, Peter O. Awinda, Keinan B Agonias, Marissa Watanabe, Danuta Szczesna-Cordary, Anna M Huckabee, Katarzyna Kazmierczak, Yemeserach Bishaw
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 320:H881-H890
Mavacamten is a pharmaceutical that binds to myosin, and it is under investigation as a therapy for some forms of heart disease. We show that mavacamten reduces isometric tension and Ca2+ sensitivity of contraction in skinned myocardial strips from a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69a40277588c30da2939131bbd1bfbd1
https://doi.org/10.1152/ajpheart.00345.2020
https://doi.org/10.1152/ajpheart.00345.2020