Non-clinical evaluation of pmIL12 gene therapy for approval of the phase I clinical study

Autor: Bostjan Markelc, Tanja Jesenko, Simona Kranjc Brezar, Masa Omerzel, Ursa Lampreht Tratar, Andrej Rencelj, Urska Matkovic, Katarina Znidar, Spela Kos, Kristina Levpuscek, Ziva Pisljar, Ursa Kesar, Tilen Komel, Tim Bozic, Aneja Tuljak, Rosana Hudej, Matjaz Peterka, Urska Kamensek, Andrej Cör, Gorana Gasljevic, Alenka Nemec Svete, Natasa Tozon, Gregor Sersa, Maja Cemazar

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)

Abstract Immunotherapeutic drugs are promising medicines for cancer treatment. A potential candidate for immunotherapy is interleukin-12 (IL-12), a cytokine well known for its ability to mediate antitumor activity. We developed a plasmid encoding hum

Externí odkaz: https://doaj.org/article/31c16b9fe1ca4c038f2fb6e10cd7146e

Non-Clinical In Vitro Evaluation of Antibiotic Resistance Gene-Free Plasmids Encoding Human or Murine IL-12 Intended for First-in-Human Clinical Study

Autor: Spela Kos, Masa Bosnjak, Tanja Jesenko, Bostjan Markelc, Urska Kamensek, Katarina Znidar, Urska Matkovic, Andrej Rencelj, Gregor Sersa, Rosana Hudej, Aneja Tuljak, Matjaz Peterka, Maja Cemazar

Publikováno v: Pharmaceutics, Vol 13, Iss 10, p 1739 (2021)

Interleukin 12 (IL-12) is a key cytokine that mediates antitumor activity of immune cells. To fulfill its clinical potential, the development is focused on localized delivery systems, such as gene electrotransfer, which can provide localized delivery

Externí odkaz: https://doaj.org/article/e0a9f59802f9407ca46068c68fbe54cd

Tumor Radiosensitization by Gene Electrotransfer-Mediated Double Targeting of Tumor Vasculature

Autor: Monika Savarin, Katarina Znidar, Gregor Sersa, Tilen Komel, Maja Cemazar, Urska Kamensek

Publikováno v: International Journal of Molecular Sciences
Volume 24
Issue 3
Pages: 2755

Targeting the tumor vasculature through specific endothelial cell markers involved in different signaling pathways represents a promising tool for tumor radiosensitization. Two prominent targets are endoglin (CD105), a transforming growth factor β c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7432337fb196c3ba267747df3af12ac

Abstract 5122: Electrochemotherapy and IL-12 gene electrotransfer in treatment of mast cell tumors in companion dogs

Autor: Maja Cemazar, Ursa Lampreht Tratar, Nina Milevoj, Katarina Znidar, Katja Ursic Valentinuzzi, Andreja Brozic, Gregor Sersa, Natasa Tozon

Publikováno v: Cancer Research. 83:5122-5122

When cells or tissues are exposed to an electric field, structural changes can be induced in the cell membrane, allowing molecules to flow into the cells. This condition is useful for delivering cytotoxic drugs whose transport into cells is impeded,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::198f019a6a7f2316ac9cf9873f54ec60
https://doi.org/10.1158/1538-7445.am2023-5122

Evaluation of a Novel Plasmid for Simultaneous Gene Electrotransfer-Mediated Silencing of CD105 and CD146 in Combination with Irradiation

Autor: Gregor Sersa, Vesna Todorovic, Katarina Znidar, Maja Cemazar, Monika Savarin, Urska Kamensek

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 6
International Journal of Molecular Sciences, Vol 22, Iss 3069, p 3069 (2021)
International journal of molecular sciences, str. 3069-1-3069-18, Vol. 22, 2021
COBISS-ID: 2779162
International journal of molecular sciences, vol. 22, pp. 3069-1-3069-18, 2021.

Targeting tumor vasculature through specific endothelial cell markers represents a promising approach for cancer treatment. Here our aim was to construct an antibiotic resistance gene-free plasmid encoding shRNAs to simultaneously target two endothel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5afb4a4071ca5d5ac521a32c9f8eb1f8