Zobrazeno 1 - 10 of 20 pro vyhledávání: '"Katarina Spilovska"'
1
Akademický článek
Profiling donepezil template into multipotent hybrids with antioxidant properties
Autor: Eva Mezeiova, Katarina Spilovska, Eugenie Nepovimova, Lukas Gorecki, Ondrej Soukup, Rafael Dolezal, David Malinak, Jana Janockova, Daniel Jun, Kamil Kuca, Jan Korabecny
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 583-606 (2018)
Alzheimer’s disease is debilitating neurodegenerative disorder in the elderly. Current therapy relies on administration of acetylcholinesterase inhibitors (AChEIs) -donepezil, rivastigmine, galantamine, and N-methyl-d-aspartate receptor antagonist
Externí odkaz: https://doaj.org/article/f4d7abc278ba4229b488013ba972aa08
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2
Akademický článek
7-Methoxytacrine-Adamantylamine Heterodimers as Cholinesterase Inhibitors in Alzheimer’s Disease Treatment — Synthesis, Biological Evaluation and Molecular Modeling Studies
Autor: Kamil Kuca, Katarina Siposova, Lucie Drtinova, Zuzana Gazova, Ondrej Soukup, Kamil Musilek, Anna Horova, Katarina Spilovska, Jan Korabecny, Jan Kral
Publikováno v: Molecules, Vol 18, Iss 2, Pp 2397-2418 (2013)
A structural series of 7-MEOTA-adamantylamine thioureas was designed, synthesized and evaluated as inhibitors of human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBChE). The compounds were prepared based on the multi-target-directe
Externí odkaz: https://doaj.org/article/e9912ee0c03b4addb65dd76f96b7a605
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3
Akademický článek
Development of 2-Methoxyhuprine as Novel Lead for Alzheimer’s Disease Therapy
Autor: Eva Mezeiova, Jan Korabecny, Vendula Sepsova, Martina Hrabinova, Petr Jost, Lubica Muckova, Tomas Kucera, Rafael Dolezal, Jan Misik, Katarina Spilovska, Ngoc Lam Pham, Lucia Pokrievkova, Jaroslav Roh, Daniel Jun, Ondrej Soukup, Daniel Kaping, Kamil Kuca
Publikováno v: Molecules, Vol 22, Iss 8, p 1265 (2017)
Tacrine (THA), the first clinically effective acetylcholinesterase (AChE) inhibitor and the first approved drug for the treatment of Alzheimer’s disease (AD), was withdrawn from the market due to its side effects, particularly its hepatotoxicity. N
Externí odkaz: https://doaj.org/article/fe0fff597e6d4ec9a5efe54879c94f4d
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4
The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease
Autor: Eugenie Nepovimova, Ondřej Soukup, Tomas Kucera, Daniel Kaping, Ngoc Lam Pham, Katarina Spilovska, Daniel Jun, L. Matouskova, M. Kerhartova, Eva Mezeiova, Lubica Muckova, Petr Jost, Kamil Kuca, Vendula Hepnarova, Frantisek Staud, Martina Hrabinova, Jan Korabecny, Rafael Dolezal, N. Vykoukalova
Publikováno v: European Journal of Medicinal Chemistry. 150:292-306
Novel tacrine-benzyl quinolone carboxylic acid (tacrine-BQCA) hybrids were designed based on multi-target directed ligands (MTLDs) paradigm, synthesized and evaluated in vitro as inhibitors of human acetylcholinesterase (hAChE) and human butyrylcholi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1052524408798595bb5c889dab7b1be1
https://doi.org/10.1016/j.ejmech.2018.02.083
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5
Newly Developed Drugs for Alzheimer’s Disease in Relation to Energy Metabolism, Cholinergic and Monoaminergic Neurotransmission
Autor: Tereza Cikánková, Jan Korábečný, Lucie Vašková, Jana Hroudová, Eva Mezeiova, Kamil Kuca, Eugenie Nepovimova, Katarina Spilovska
Publikováno v: Neuroscience. 370:191-206
Current options for Alzheimer's disease (AD) treatment are based on administration of cholinesterase inhibitors (donepezil, rivastigmine, galantamine) and/or memantine, acting as an N-methyl-D-aspartate (NMDA). Therapeutic approaches vary and include
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b8aaaec2760344db4f8e2dcc9ba7f95
https://doi.org/10.1016/j.neuroscience.2017.06.034
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6
Profiling donepezil template into multipotent hybrids with antioxidant properties
Autor: Jana Janockova, Ondrej Soukup, Katarina Spilovska, Eugenie Nepovimova, Eva Mezeiova, Jan Korabecny, Rafael Dolezal, Kamil Kuca, David Malinak, Daniel Jun, Lukas Gorecki
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 583-606 (2018)
Journal of Enzyme Inhibition and Medicinal Chemistry
Alzheimer’s disease is debilitating neurodegenerative disorder in the elderly. Current therapy relies on administration of acetylcholinesterase inhibitors (AChEIs) -donepezil, rivastigmine, galantamine, and N-methyl-d-aspartate receptor antagonist
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db2be08cb71005c25510087c2ddec3c5
https://doi.org/10.1080/14756366.2018.1443326
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8
Design, synthesis and in vitro testing of 7-methoxytacrine-amantadine analogues: a novel cholinesterase inhibitors for the treatment of Alzheimer’s disease
Autor: Katarina Siposova, Kamil Musilek, Daniel Jun, Zuzana Gazova, Anna Horova, Eugenie Nepovimova, Katarina Spilovska, Jan Korabecny, Rafael Dolezal, Kamil Kuca, Lucie Drtinova
Publikováno v: Medicinal Chemistry Research. 24:2645-2655
A series of cholinesterase inhibitors acting as dual binding site heterodimers for the management of Alzheimer’s disease were developed. The series of 7-methoxytacrine (7-MEOTA)-amantadine ureas (11–17) was designed, prepared evaluated in vitro t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7d0ffead6a64e8fe25ff9e911e7527ec
https://doi.org/10.1007/s00044-015-1316-x
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9
Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer’s Agents: Design, Synthesis and Biological Evaluation
Autor: Petr Jost, Daniel Jun, Jan Korabecny, Tomas Kucera, Ondrej Soukup, Martina Hrabinova, Eva Mezeiova, Rafael Dolezal, Daniel Kaping, Lubica Muckova, Vendula Sepsova, Katarina Spilovska, Kamil Kuca, Jana Janockova
Publikováno v: Molecules; Volume 22; Issue 6; Pages: 1006
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
A novel series of 6-chlorotacrine-scutellarin hybrids was designed, synthesized and the biological activity as potential anti-Alzheimer’s agents was assessed. Their inhibitory activity towards human acetylcholinesterase (hAChE) and human butyrylcho
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1c24a48e5a1f4b71c3f9867db3a767c
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