Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Katarina Gradin"'
Autor:
Ana Mota, Szymon Berezicki, Erik Wernersson, Luuk Harbers, Xiaoze Li-Wang, Katarina Gradin, Christiane Peuckert, Nicola Crosetto, Magda Bienko
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Chromatin compaction affects many nuclear processes yet compaction levels at individual genomic loci have been notoriously difficult to assess. Here, Ana Mota and co-authors from the Bienko-Crosetto Lab present FRET-FISH for probing chromatin compact
Externí odkaz:
https://doaj.org/article/33370e912aec4d96af6d429578b164aa
Autor:
Wendi Sun, Hiroyuki Kato, Shojiro Kitajima, Kian Leong Lee, Katarina Gradin, Takashi Okamoto, Lorenz Poellinger
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Hypoxia-inducible factors (HIFs) play a central role in the transcriptional response to changes in oxygen availability. Stability of HIFs is regulated by multi-step reactions including recognition by the von Hippel-Lindau tumour suppressor p
Externí odkaz:
https://doaj.org/article/54e312178c074791ab1118dadbc35278
The density or compaction of chromatin throughout the cell nucleus is a key biophysical property that influences DNA replication, transcription, and repair. Chromatin accessibility is often used as a proxy for chromatin compaction or density, however
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36c398b0798b72999e0d7cde29280542
https://doi.org/10.21203/rs.3.rs-1130822/v1
https://doi.org/10.21203/rs.3.rs-1130822/v1
Autor:
Hideaki Nakamura, Hiroki Sekine, Hiroyuki Kato, Hisao Masai, Katarina Gradin, Lorenz Poellinger
Publikováno v:
The Journal of biological chemistry. 298(7)
Upregulation of Notch3 expression has been reported in many cancers and is considered a marker for poor prognosis. Hypoxia is a driving factor of the Notch3 signaling pathway; however, the induction mechanism and role of hypoxia-inducible factor-1α
Publikováno v:
Experimental Cell Research. 356:182-186
Hypoxia causes dramatic changes in the expression profiles of genes that encode glycolytic enzymes, vascular endothelial growth factors, erythropoietin, and other factors in a tissue-specific manner through activating hypoxia-inducible transcription
Autor:
Teresa S. Pereira, Kian Leong Lee, Yusuf Ali, Xiaofeng Zheng, Per Olof Berggren, Katarina Gradin, Calvin Qing Wei Ho, Xiaowei Zheng
Publikováno v:
J Vis Exp
Low oxygen levels (hypoxia) trigger a variety of adaptive responses with the Hypoxia-inducible factor 1 (HIF-1) complex acting as a master regulator. HIF-1 consists of a heterodimeric oxygen-regulated α subunit (HIF-1α) and constitutively expressed
Autor:
Henry Yang, Norio Suzuki, Kian Leong Lee, Katarina Gradin, Nikola Vojnovic, Lorenz Poellinger
Publikováno v:
Experimental cell research. 366(2)
Hypoxia causes dramatic changes in gene expression profiles, and the mechanism of hypoxia-inducible transcription has been analyzed for use as a model system of stress-inducible gene regulation. In this study, changes in chromatin organization in pro
Autor:
Sandra Luecke-Johansson, Jolene Caifeng Ho, Randall S. Johnson, Katarina Gradin, Helene Rundqvist, Michael Gralla, Lorenz Poellinger
Publikováno v:
Molecular and Cellular Biology. 37
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that is known as a mediator of toxic responses. Recently, it was shown that the AhR has dual functions. Besides being a transcription factor, it also possesses an intrinsi
Autor:
Sandra Luecke-Johansson, Teresa Pereira, Xiaofeng Zheng, Lorenz Poellinger, Sampath Narayanan, Xiaowei Zheng, Sergiu-Bogdan Catrina, Katarina Gradin
Publikováno v:
Experimental cell research. 358(2)
Hes1 is a Notch target gene that plays a major role during embryonic development. Previous studies have shown that HIF-1α can interact with the Notch intracellular domain and enhance Notch target gene expression. In this study, we have identified a
Autor:
Kristin Wollenick, Roland H. Wenger, Peter Schraml, Lorenz Poellinger, Irene Abreu-Rodríguez, Daniel P. Stiehl, Katarina Gradin, Glen Kristiansen, M R Bordoli
Publikováno v:
Oncogene
Tumor progression is intrinsically tied to the clonal selection of tumor cells with acquired phenotypes allowing to cope with a hostile microenvironment. Hypoxia inducible factors (HIFs) master the transcriptional response to local tissue hypoxia a h