Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Katarina Grabrijan"'
Autor:
Levente Kollár, Katarina Grabrijan, Martina Hrast Rambaher, Krištof Bozovičar, Tímea Imre, György G. Ferenczy, Stanislav Gobec, György M. Keserű
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
AbstractPenicillin-binding proteins (PBPs) contribute to bacterial cell wall biosynthesis and are targets of antibacterial agents. Here, we investigated PBP1b inhibition by boronic acid derivatives. Chemical starting points were identified by structu
Externí odkaz:
https://doaj.org/article/3aa73b81e4b544ed9ddec929dc30123d
Autor:
Péter Ábrányi-Balogh, Aaron Keeley, György G. Ferenczy, László Petri, Tímea Imre, Katarina Grabrijan, Martina Hrast, Damijan Knez, Janez Ilaš, Stanislav Gobec, György M. Keserű
Publikováno v:
Pharmaceuticals, Vol 15, Iss 12, p 1484 (2022)
Heterocyclic electrophiles as small covalent fragments showed promising inhibitory activity on the antibacterial target MurA (UDP-N-acetylglucosamine 1-carboxyvinyltransferase, EC:2.5.1.7). Here, we report the second generation of heterocyclic electr
Externí odkaz:
https://doaj.org/article/df22a37fca3f4388a828d755b3209126
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 1, p 360 (2021)
Monocyclic ß-lactams (azetidin-2-ones) exhibit a wide range of biological activities, the most important of which are antibacterial, anticancer, and cholesterol absorption inhibitory activities. The synthesis of decorated monocyclic ß-lactams is ch
Externí odkaz:
https://doaj.org/article/91daae4f2919416696cc1d7006799d0b
Autor:
Ales Obreza, Katarina Grabrijan, Selmir Kadić, Fernando Juan de Lera Garrido, Izidor Sosič, Stanislav Gobec, Marko Jukič
Publikováno v:
Acta Chimica Slovenica, Vol 64, Iss 4, Pp 771-781 (2017)
Using rescaffolding approach, we designed piperidine compounds decorated with an electrophilic oxathiazol-2-one moiety that is known to confer selectivity towards threonine proteases. Our efforts to prepare products according to the published procedu
Externí odkaz:
https://doaj.org/article/8d35d2c7795842f1ad7bb5a288d7f70e
Autor:
Matic Proj, Martina Hrast, Damijan Knez, Krištof Bozovičar, Katarina Grabrijan, Anže Meden, Stanislav Gobec, Rok Frlan
Publikováno v:
ACS medicinal chemistry letters. 13(12)
Thiazoles exhibit a wide range of biological activities and therefore represent useful and attractive building blocks. To evaluate their usefulness and pinpoint their liabilities in fragment screening campaigns, we assembled a focused library of 49 f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::094b30a68a94ec61d5f50c5b3094f8d4
https://pubmed.ncbi.nlm.nih.gov/36518695
https://pubmed.ncbi.nlm.nih.gov/36518695
Covalent inhibitors of bacterial peptidoglycan biosynthesis enzyme MurA with chloroacetamide warhead
Autor:
Katarina Grabrijan, Martina Hrast, Matic Proj, Ana Dolšak, Irena Zdovc, Tímea Imre, László Petri, Péter Ábrányi-Balogh, György M. Keserű, Stanislav Gobec
Publikováno v:
European journal of medicinal chemistry, vol. 243, 114752, 2022.
European journal of medicinal chemistry, 15 str. : Ilustr., Vol. 243, 2022
COBISS-ID: 25429760
European journal of medicinal chemistry, 15 str. : Ilustr., Vol. 243, 2022
COBISS-ID: 25429760
MurA (UDP-N-acetylglucosamine enolpyruvyl transferase) catalyzes the first committed step in the cytoplasmic part of peptidoglycan biosynthesis and is a validated target enzyme for antibacterial drug discovery; the inhibitor fosfomycin has been used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f34758dec7221e92b09df5bda2613d3f
https://doi.org/10.1016/j.ejmech.2022.114752
https://doi.org/10.1016/j.ejmech.2022.114752
Publikováno v:
Expert opinion on therapeutic patents. 31(3)
Monocyclic beta-lactams are four-membered cyclic amides with various structural modifications of the nucleus that determine their chemical reactivity and target specificity. Their historical use is based on their antibacterial activity, but they have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b29efeb234ebf14df80a30fe6006918
https://pubmed.ncbi.nlm.nih.gov/33327805
https://pubmed.ncbi.nlm.nih.gov/33327805
Autor:
Pavla Paterová, Ondřej Janďourek, Izidor Sosič, Vinod S.K. Pallabothula, Jan Zitko, Katarina Grabrijan, Martin Juhás, Pavel Barta, Klára Konečná, Martina Šimovičová, Stanislav Gobec
Publikováno v:
Bioorganic Chemistry. 118:105489
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) is the number one cause of deaths due to a single infectious agent worldwide. The treatment of TB is lengthy and often complicated by the increasing drug resistance. New compounds with new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a402dcb5276620e99ac93b3eb588dac
https://doi.org/10.1016/j.bioorg.2021.105489
https://doi.org/10.1016/j.bioorg.2021.105489
Autor:
Marko Jukič, Stanislav Gobec, Aleš Obreza, Selmir Kadić, Izidor Sosič, Katarina Grabrijan, Fernando Juan de Lera Garrido
Publikováno v:
Acta chimica slovenica
Acta Chimica Slovenica, Vol 64, Iss 4, Pp 771-781 (2017)
Acta Chimica Slovenica, Vol 64, Iss 4, Pp 771-781 (2017)
Using rescaffolding approach, we designed piperidine compounds decorated with an electrophilic oxathiazol-2-one moiety that is known to confer selectivity towards threonine proteases. Our efforts to prepare products according to the published procedu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::913790410d02162e81b0af59988292e2
http://www.dlib.si/details/URN:NBN:SI:doc-A79RAVF8
http://www.dlib.si/details/URN:NBN:SI:doc-A79RAVF8
