Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Katarina Dahlenborg"'
Autor:
Göran Roos, Roland Carlsson, Magnus Hultdin, Pia Osterman, Karl-Fredrik Norrback, Katarina Dahlenborg
Publikováno v:
European Journal of Haematology. 67:309-317
Telomere length maintenance, usually executed by telomerase, is a prerequisite for an extended or infinite division potential. Nevertheless most telomerase positive normal cells exhibit telomere shortening. This study details the telomerase expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed5b82b35457f4b3fded8c1ad9cd992e
https://doi.org/10.1034/j.1600-0609.2001.00588.x
https://doi.org/10.1034/j.1600-0609.2001.00588.x
Autor:
Katarina Dahlenborg, Sabine Middendorp, Gemma M. Dingjan, Alex Maas, Rudolf W. Hendriks, Frank Grosveld
Publikováno v:
Journal of Experimental Medicine, 193(10), 1169-1178. Rockefeller University Press
The Journal of Experimental Medicine
The Journal of Experimental Medicine
Bruton's tyrosine kinase (Btk) is a nonreceptor tyrosine kinase involved in precursor B (pre-B) cell receptor signaling. Here we demonstrate that Btk-deficient mice have an approximately 50% reduction in the frequency of immunoglobulin (Ig) lambda li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::728f6bbdc15f7da4624dd8af88c568d9
https://doi.org/10.1084/jem.193.10.1169
https://doi.org/10.1084/jem.193.10.1169
Publikováno v:
Immunology. 101:210-217
SUMMARY Affinity maturation of antibody responses depends on somatic hypermutation of the immunoglobulin V genes. Hypermutation is initiated specifically in proliferating B cells in lymphoid germinal centres but the signals driving this process remai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f538695d3f825eead528ef157826fbb
https://doi.org/10.1046/j.1365-2567.2000.00091.x
https://doi.org/10.1046/j.1365-2567.2000.00091.x
Publikováno v:
International Immunology. 11:739-744
The precise signaling pathways to induce a germinal center (GC) phenotype and somatic mutations in human B cells are presently not understood. Major phenotypical hallmarks of a human GC B cell are up-regulated expression of CD10 and CD95 together wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9137ade00ac4ede8ed5ea4fe7a357687
https://doi.org/10.1093/intimm/11.5.739
https://doi.org/10.1093/intimm/11.5.739
Publikováno v:
Cellular Immunology. 169:166-173
Germinal centers (GC) are well-defined areas in lymphoid organs were B cells proliferate and differentiate in response to T-cell-dependent antigens. The GC comprises B cells, follicular dendritic cells, tangible body macrophages, and a low number of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2ddfdae42ee7512dbec19f0257a9616
https://doi.org/10.1006/cimm.1996.0107
https://doi.org/10.1006/cimm.1996.0107
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 171(11)
The Tec family member Bruton’s tyrosine kinase (Btk) is a cytoplasmic protein tyrosine kinase that transduces signals from the pre-B and B cell receptor (BCR). Btk is involved in pre-B cell maturation by regulating IL-7 responsiveness, cell surface
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d26c4ff999b92419a30a93b44f2a624
https://pubmed.ncbi.nlm.nih.gov/14634110
https://pubmed.ncbi.nlm.nih.gov/14634110
Publikováno v:
Cellular immunology. 175(2)
In order to define an in vitro culture system allowing growth of single human germinal center B cells (GC-B), we have studied the proliferation and differentiation of human tonsillar GC-B, and subsets thereof, when cultured together with murine EL-4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8aab97d5758a8b371c0c1b295d0cffa
https://pubmed.ncbi.nlm.nih.gov/9023419
https://pubmed.ncbi.nlm.nih.gov/9023419
Publikováno v:
International journal of cancer. 70(1)
Five hybridomas producing human monoclonal antibodies (MAbs) of IgA and IgM isotypes reacting with the tumour associated TF antigen were generated after in vitro immunisation or antigen specific isolation of normal peripheral blood B cells using asia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1997f5aff0c4017d75687677d13a9ab
https://pubmed.ncbi.nlm.nih.gov/8985092
https://pubmed.ncbi.nlm.nih.gov/8985092
Publikováno v:
Blood. 88(1)
Activation of telomerase seems to be a prerequisite for immortalization and is found in permanent cell lines and most malignant tumors. Normal somatic cells are generally telomerase negative, except for bone marrow stem cells. Weak activity is also p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac02c9fca656e8bb7c3429c03ed094d0
https://pubmed.ncbi.nlm.nih.gov/8704177
https://pubmed.ncbi.nlm.nih.gov/8704177