Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Katarína Vorčáková"'
2-Hydroxy-N-phenylbenzamides and Their Esters Inhibit Acetylcholinesterase and Butyrylcholinesterase
Autor:
Martin Krátký, Šárka Štěpánková, Neto-Honorius Houngbedji, Rudolf Vosátka, Katarína Vorčáková, Jarmila Vinšová
Publikováno v:
Biomolecules, Vol 9, Iss 11, p 698 (2019)
The development of novel inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) represents a viable approach to alleviate Alzheimer’s disease. Thirty-six halogenated 2-hydroxy-N-phenylbenzamides (salicylanilides) with various s
Externí odkaz:
https://doaj.org/article/827e22d74bb147fc85350ec30870a88a
Autor:
Jarmila Vinšová, Martin Krátký, Markéta Komlóová, Echchukattula Dadapeer, Šárka Štěpánková, Katarína Vorčáková, Jiřina Stolaříková
Publikováno v:
Molecules, Vol 19, Iss 6, Pp 7152-7168 (2014)
A new series of 27 diethyl 2-(phenylcarbamoyl)phenyl phosphorothioates (thiophosphates) was synthesized, characterized by NMR, IR and CHN analyses and evaluated against Mycobacterium tuberculosis H37Rv, Mycobacterium avium and two strains of Mycobact
Externí odkaz:
https://doaj.org/article/61e6a30b8749480ba20de41b367501d3
Publikováno v:
Molecules, Vol 21, Iss 2, p 191 (2016)
Based on the presence of carbamoyl moiety, twenty salicylanilide N,N-disubstituted (thio)carbamates were investigated using Ellman’s method for their ability to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). O-Aromatic (thio)
Externí odkaz:
https://doaj.org/article/1c358195046647c3a0b097c55cdc60a2
Publikováno v:
Bioorganic Chemistry. 80:668-673
Based on the presence of carbamate moiety, twenty salicylanilide N-monosubstituted carbamates concomitantly with their parent salicylanilides and five newly prepared 4-chlorophenyl carbamates obtained from isocyanates were investigated using Ellman
Autor:
Adam Smoliński, Hana Pizova, Josef Jampilek, Andrzej Bak, Ales Imramovsky, Violetta Kozik, Jiri Kos, Zdeněk Trávníček, Katarína Vorčáková, Jakub Treml, Klara Odehnalova, Pavel Bobal, Michal Oravec
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 21, p 5385 (2019)
International Journal of Molecular Sciences
Volume 20
Issue 21
International Journal of Molecular Sciences
Volume 20
Issue 21
A set of 25 novel, silicon-based carbamate derivatives as potential acetyl- and butyrylcholinesterase (AChE/BChE) inhibitors was synthesized and characterized by their in vitro inhibition profiles and the selectivity indexes (SIs). The prepared compo
Autor:
Katarína Vorčáková, Lucie Navrátilová, Šárka Štěpánková, Martin Krátký, Jiřina Stolaříková, Jarmila Vinšová, František Trejtnar
Publikováno v:
Bioorganic Chemistry. 71:244-256
A series of thirty novel N-acetylated fluorophenylalanine-based aromatic amides and esters was synthesized using N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide or phosphorus trichloride in pyridine. They were characterized by spectral methods and scr
Autor:
Šárka Štěpánková, Katarína Vorčáková
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry. 31:180-193
Recently, cholinesterase-based biosensors are widely used for assaying anticholinergic compounds. Primarily biosensors based on enzyme inhibition are useful analytical tools for fast screening of inhibitors, such as organophosphates and carbamates. T
Autor:
Magdalena Majekova, Eva Horáková, Miloš Sedlák, Šárka Štěpánková, Pavel Drabina, Katarína Vorčáková
Publikováno v:
Bioorganic chemistry. 78
Based on current treatment of Alzheimer's disease, where the carbamate inhibitor Rivastigmine is used, two series of carbamate derivatives were prepared: (i) N-phenylcarbamates with additional carbamate group (1-12) and (ii) N-phenylcarbamates with m
Autor:
Katarína Vorčáková, Marketa Komloova, Šárka Štěpánková, Echchukattula Dadapeer, Jiřina Stolaříková, Jarmila Vinšová, Martin Krátký
Publikováno v:
Molecules; Volume 19; Issue 6; Pages: 7152-7168
Molecules, Vol 19, Iss 6, Pp 7152-7168 (2014)
Molecules
Molecules, Vol 19, Iss 6, Pp 7152-7168 (2014)
Molecules
A new series of 27 diethyl 2-(phenylcarbamoyl)phenyl phosphorothioates (thiophosphates) was synthesized, characterized by NMR, IR and CHN analyses and evaluated against Mycobacterium tuberculosis H37Rv, Mycobacterium avium and two strains of Mycobact
Autor:
Břetislav Brož, Radim Havelek, Katarína Vorčáková, Miloš Sedlák, Pavel Drabina, Šárka Štěpánková, Karel Královec, Eva Horáková
Publikováno v:
Journal of enzyme inhibition and medicinal chemistry. 31(sup3)
A serie of O-substituted N-2-phenylcyclopropylcarbamates was prepared and characterized. These carbamates were tested as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). It was found, that these compounds exhibit moderate i