Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Katarína Tiklová"'
Autor:
Ioannis Mantas, Ivana Flais, Yuvarani Masarapu, Tudor Ionescu, Solène Frapard, Felix Jung, Pierre Le Merre, Marcus Saarinen, Katarina Tiklova, Behzad Yaghmaeian Salmani, Linda Gillberg, Xiaoqun Zhang, Karima Chergui, Marie Carlén, Stefania Giacomello, Bastian Hengerer, Thomas Perlmann, Per Svenningsson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract The Claustrum/dorsal endopiriform cortex complex (CLA) is an enigmatic brain region with extensive glutamatergic projections to multiple cortical areas. The transcription factor Nurr1 is highly expressed in the CLA, but its role in this regi
Externí odkaz:
https://doaj.org/article/f723ec46d21f4e5683d1ae7079739299
Autor:
Roberta Filograna, Jule Gerlach, Hae-Na Choi, Giovanni Rigoni, Michela Barbaro, Mikael Oscarson, Seungmin Lee, Katarina Tiklova, Markus Ringnér, Camilla Koolmeister, Rolf Wibom, Sara Riggare, Inger Nennesmo, Thomas Perlmann, Anna Wredenberg, Anna Wedell, Elisa Motori, Per Svenningsson, Nils-Göran Larsson
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract Loss-of-function variants in the PRKN gene encoding the ubiquitin E3 ligase PARKIN cause autosomal recessive early-onset Parkinson’s disease (PD). Extensive in vitro and in vivo studies have reported that PARKIN is involved in multiple pat
Externí odkaz:
https://doaj.org/article/5261e43905b84e29a138f193cac7150a
Autor:
Katarína Tiklová, Sara Nolbrant, Alessandro Fiorenzano, Åsa K. Björklund, Yogita Sharma, Andreas Heuer, Linda Gillberg, Deirdre B. Hoban, Tiago Cardoso, Andrew F. Adler, Marcella Birtele, Hilda Lundén-Miguel, Nikolaos Volakakis, Agnete Kirkeby, Thomas Perlmann, Malin Parmar
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
What happens to cells on engrafting into the brain in animal models to treat Parkinson’s disease is unclear. Here, the authors use scRNA-seq to examine ventral midbrain (VM)-patterned human embryonic stem cells after functional maturation in a pre-
Externí odkaz:
https://doaj.org/article/e42834ed181548b18cc8c7636ddae20d
Autor:
Katarína Tiklová, Linda Gillberg, Nikolaos Volakakis, Hilda Lundén-Miguel, Lina Dahl, Geidy E. Serrano, Charles H. Adler, Thomas G. Beach, Thomas Perlmann
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Analyses of gene expression in cells affected by neurodegenerative disease can provide important insights into disease mechanisms and relevant stress response pathways. Major symptoms in Parkinson’s disease (PD) are caused by the degeneration of mi
Externí odkaz:
https://doaj.org/article/2688c8e2113b4db987bfcd1c61b338d9
Autor:
Roberta Filograna, Seungmin Lee, Katarína Tiklová, Mara Mennuni, Viktor Jonsson, Markus Ringnér, Linda Gillberg, Elena Sopova, Oleg Shupliakov, Camilla Koolmeister, Lars Olson, Thomas Perlmann, Nils-Göran Larsson
Publikováno v:
PLoS Genetics, Vol 17, Iss 9, p e1009822 (2021)
Dopamine (DA) neurons of the midbrain are at risk to become affected by mitochondrial damage over time and mitochondrial defects have been frequently reported in Parkinson's disease (PD) patients. However, the causal contribution of adult-onset mitoc
Externí odkaz:
https://doaj.org/article/61f2fcf7bb484163bdda169112e41b0e
Autor:
Katarína Tiklová, Åsa K. Björklund, Laura Lahti, Alessandro Fiorenzano, Sara Nolbrant, Linda Gillberg, Nikolaos Volakakis, Chika Yokota, Markus M. Hilscher, Thomas Hauling, Fredrik Holmström, Eliza Joodmardi, Mats Nilsson, Malin Parmar, Thomas Perlmann
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Midbrain dopamine (mDA) neurons are significantly associated with Parkinson’s disease and yet there is no systematic molecular classification of these heterogenous group of cells. Here authors use single cell RNA sequencing of isolated mouse neuron
Externí odkaz:
https://doaj.org/article/fb22d9e2478a422ebc121e8f033474f4
Autor:
Katarína Tiklová, Sara Nolbrant, Alessandro Fiorenzano, Åsa K. Björklund, Yogita Sharma, Andreas Heuer, Linda Gillberg, Deirdre B. Hoban, Tiago Cardoso, Andrew F. Adler, Marcella Birtele, Hilda Lundén-Miguel, Nikolaos Volakakis, Agnete Kirkeby, Thomas Perlmann, Malin Parmar
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/07caa5d96c2949738e0c1d2aeb44e50d
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e67415 (2013)
The transporting function of many branched tubular networks like our lungs and circulatory system depend on the sizes and shapes of their branches. Understanding the mechanisms of tube size control during organ development may offer new insights into
Externí odkaz:
https://doaj.org/article/f33f1a7c76514624bfe7061b58a43699
Autor:
Satish Arcot Jayaram, Kirsten-André Senti, Katarína Tiklová, Vasilios Tsarouhas, Johanna Hemphälä, Christos Samakovlis
Publikováno v:
PLoS ONE, Vol 3, Iss 4, p e1964 (2008)
BACKGROUND: Tube expansion defects like stenoses and atresias cause devastating human diseases. Luminal expansion during organogenesis begins to be elucidated in several systems but we still lack a mechanistic view of the process in many organs. The
Externí odkaz:
https://doaj.org/article/beb2c3454f0d41d58896887186970c46
Autor:
Anastasia Magoulopoulou, Sergio Marco Salas, Katarína Tiklová, Erik Reinhold Samuelsson, Markus M. Hilscher, Mats Nilsson
Publikováno v:
Annual Review of Genomics and Human Genetics. 24
Elucidating spatiotemporal changes in gene expression has been an essential goal in studies of health, development, and disease. In the emerging field of spatially resolved transcriptomics, gene expression profiles are acquired with the tissue archit