Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Katarína Mikušová"'
Autor:
Dongguang Fan, Bin Wang, Giovanni Stelitano, Karin Savková, Olga Riabova, Rui Shi, Xiaomei Wu, Laurent R. Chiarelli, Katarína Mikušová, Vadim Makarov, Yu Lu, Yuzhi Hong, Chunhua Qiao
Publikováno v:
Biomedicines, Vol 11, Iss 7, p 1975 (2023)
Tuberculosis (TB) is a leading infectious disease with serious antibiotic resistance. The benzothiazinone (BTZ) scaffold PBTZ169 kills Mycobacterium tuberculosis (Mtb) through the inhibition of the essential cell wall enzyme decaprenylphosphoryl-β-D
Externí odkaz:
https://doaj.org/article/c649305bde0d4225a0c4804bafa5aa5a
Autor:
Marek Baráth, Jana Jakubčinová, Zuzana Konyariková, Stanislav Kozmon, Katarína Mikušová, Maroš Bella
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 1853-1862 (2020)
A series of ten novel ᴅ-fructofuranosyl and ᴅ-tagatofuranosyl sulfones bearing a 1-O-phosphono moiety and three different substituents at C-2 has been prepared. Due to the structural similarities of these scaffolds to the native substrate of myco
Externí odkaz:
https://doaj.org/article/da11b347d334467c9d2c8919472bb659
Autor:
David Albesa-Jové, Zuzana Svetlíková, Montse Tersa, Enea Sancho-Vaello, Ana Carreras-González, Pascal Bonnet, Pedro Arrasate, Ander Eguskiza, Shiva K. Angala, Javier O. Cifuente, Jana Korduláková, Mary Jackson, Katarína Mikušová, Marcelo E. Guerin
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
PatA is a membrane-associated acyltransferase that is essential for the biosynthesis of mycobacterial glycolipids. Here, Albesa-Jovéet al. describe structures of PatA from Mycobacterium smegmatisin complex with acyl donors and show that catalysis oc
Externí odkaz:
https://doaj.org/article/345eecca519f4563aed75b57f445943c
Autor:
Vadim Makarov, Katarína Mikušová
Publikováno v:
Applied Sciences, Vol 10, Iss 7, p 2269 (2020)
Macozinone, a piperazine-benzothiazinone PBTZ169, is currently undergoing Phase 1/2 clinical studies for the treatment of tuberculosis (TB). In this review we summarize the key findings that led to the development of this compound and to identificati
Externí odkaz:
https://doaj.org/article/0a8206f24fee4e8ab3edc890546a5162
Publikováno v:
Antibiotics, Vol 9, Iss 1, p 20 (2020)
While target-based drug design has proved successful in several therapeutic areas, this approach has not yet provided compelling outcomes in the field of antibacterial agents. This statement remains especially true for the development of novel therap
Externí odkaz:
https://doaj.org/article/4bda942a627a48d2b9066c344f647824
Autor:
Kevin Pethe, Karin Savková, Lowell D. Markley, Marvin J. Miller, Rui Ma, Gauri Shetye, Garrett C. Moraski, Bei Shi Lee, Katarína Mikušová, Patricia A. Miller, Rui Liu, Scott G. Franzblau
Publikováno v:
RSC Med Chem
The formation efficiency of hydride-induced Meisenheimer complexes of nitroaromatic compounds is consistent with their anti-TB activities exemplied by MDL860 and benzothiazol N-oxide (BTO) analogs. Herein we report that nitro cyano phenoxybenzenes (M
Autor:
Fan Dongguang, Bin Wang, Giovanni Stelitano, Karin Savková, Olga Riabova, Rui Shi, Xiaomei Wu, Laurent R. Chiarelli, Katarína Mikušová, Vadim Makarov, Yu Lu, Yuzhi Hong, Chunhua Qiao
Publikováno v:
SSRN Electronic Journal.
Tuberculosis (TB) is a leading infectious disease with serious antibiotic resistance. The benzothiazinone (BTZ) scaffold PBTZ169, an inhibitor of the decaprenylphosphoryl-β-D-ribose 2'-oxidase (DprE1) in Mycobacterium tuberculosis (Mtb), showed anti
Autor:
Zuzana Pakanová, Karin Savková, Michal Kaliňák, Martina Tesařová, Jana Korduláková, Marie Vancová, Stanislav Kozmon, Stanislav Huszár, Jaroslav Blaško, Peter Barath, Katarína Mikušová, Vinayak Singh
Publikováno v:
Proc Natl Acad Sci U S A
Mycobacterium tuberculosis, one of the deadliest pathogens in human history, is distinguished by a unique, multilayered cell wall, which offers the bacterium a high level of protection from the attacks of the host immune system. The primary structure
Autor:
Natalia, Monakhova, Jana, Korduláková, Anthony, Vocat, Anna, Egorova, Alexander, Lepioshkin, Elena G, Salina, Jozef, Nosek, Eva, Repková, Júlia, Zemanová, Helena, Jurdáková, Renáta, Górová, Jaroslav, Roh, Giulia, Degiacomi, José Camilla, Sammartino, Maria Rosalia, Pasca, Stewart T, Cole, Katarína, Mikušová, Vadim, Makarov
Publikováno v:
ACS infectious diseases. 7(1)
Latent
Autor:
Dongguang Fan, Katarína Mikušová, Yiwen Xu, Josè Camilla Sammartino, Zhaogang Sun, Karin Savková, Laurent R. Chiarelli, Chengcheng Kong, Lingfeng Liu, Marco Fumagalli, Stanislav Huszár, Chunhua Qiao
Publikováno v:
European journal of medicinal chemistry. 208
Decaprenylphosphoryl-β-d-ribose 2'-oxidoreductase (DprE1) is a promising drug target for the development of novel anti-tubercular agents, and inhibitors of DprE1 are being investigated extensively. Among them, the 1,3-benzothiazinone compounds such