Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Katarína Mikušová"'
Autor:
Dongguang Fan, Bin Wang, Giovanni Stelitano, Karin Savková, Olga Riabova, Rui Shi, Xiaomei Wu, Laurent R. Chiarelli, Katarína Mikušová, Vadim Makarov, Yu Lu, Yuzhi Hong, Chunhua Qiao
Publikováno v:
Biomedicines, Vol 11, Iss 7, p 1975 (2023)
Tuberculosis (TB) is a leading infectious disease with serious antibiotic resistance. The benzothiazinone (BTZ) scaffold PBTZ169 kills Mycobacterium tuberculosis (Mtb) through the inhibition of the essential cell wall enzyme decaprenylphosphoryl-β-D
Externí odkaz:
https://doaj.org/article/c649305bde0d4225a0c4804bafa5aa5a
Autor:
Marek Baráth, Jana Jakubčinová, Zuzana Konyariková, Stanislav Kozmon, Katarína Mikušová, Maroš Bella
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 1853-1862 (2020)
A series of ten novel ᴅ-fructofuranosyl and ᴅ-tagatofuranosyl sulfones bearing a 1-O-phosphono moiety and three different substituents at C-2 has been prepared. Due to the structural similarities of these scaffolds to the native substrate of myco
Externí odkaz:
https://doaj.org/article/da11b347d334467c9d2c8919472bb659
Autor:
David Albesa-Jové, Zuzana Svetlíková, Montse Tersa, Enea Sancho-Vaello, Ana Carreras-González, Pascal Bonnet, Pedro Arrasate, Ander Eguskiza, Shiva K. Angala, Javier O. Cifuente, Jana Korduláková, Mary Jackson, Katarína Mikušová, Marcelo E. Guerin
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
PatA is a membrane-associated acyltransferase that is essential for the biosynthesis of mycobacterial glycolipids. Here, Albesa-Jovéet al. describe structures of PatA from Mycobacterium smegmatisin complex with acyl donors and show that catalysis oc
Externí odkaz:
https://doaj.org/article/345eecca519f4563aed75b57f445943c
Autor:
Vadim Makarov, Katarína Mikušová
Publikováno v:
Applied Sciences, Vol 10, Iss 7, p 2269 (2020)
Macozinone, a piperazine-benzothiazinone PBTZ169, is currently undergoing Phase 1/2 clinical studies for the treatment of tuberculosis (TB). In this review we summarize the key findings that led to the development of this compound and to identificati
Externí odkaz:
https://doaj.org/article/0a8206f24fee4e8ab3edc890546a5162
Publikováno v:
Antibiotics, Vol 9, Iss 1, p 20 (2020)
While target-based drug design has proved successful in several therapeutic areas, this approach has not yet provided compelling outcomes in the field of antibacterial agents. This statement remains especially true for the development of novel therap
Externí odkaz:
https://doaj.org/article/4bda942a627a48d2b9066c344f647824
Autor:
Kevin Pethe, Karin Savková, Lowell D. Markley, Marvin J. Miller, Rui Ma, Gauri Shetye, Garrett C. Moraski, Bei Shi Lee, Katarína Mikušová, Patricia A. Miller, Rui Liu, Scott G. Franzblau
Publikováno v:
RSC Med Chem
The formation efficiency of hydride-induced Meisenheimer complexes of nitroaromatic compounds is consistent with their anti-TB activities exemplied by MDL860 and benzothiazol N-oxide (BTO) analogs. Herein we report that nitro cyano phenoxybenzenes (M
Autor:
Eva Repková, Jaroslav Roh, Júlia Zemanová, Jana Korduláková, Natalia Monakhova, Jozef Nosek, Maria Rosalia Pasca, Anna Egorova, Josè Camilla Sammartino, Giulia Degiacomi, Vadim Makarov, Elena G. Salina, Renáta Górová, Anthony Vocat, Alexander Lepioshkin, Katarína Mikušová, Helena Jurdáková, Stewart T. Cole
Publikováno v:
ACS Infectious Diseases. 7:88-100
Latent Mycobacterium tuberculosis infection presents one of the largest challenges for tuberculosis control and novel antimycobacterial drug development. A series of pyrano[3,2-b]indolone-based compounds was designed and synthesized via an original e
Autor:
Fan Dongguang, Bin Wang, Giovanni Stelitano, Karin Savková, Olga Riabova, Rui Shi, Xiaomei Wu, Laurent R. Chiarelli, Katarína Mikušová, Vadim Makarov, Yu Lu, Yuzhi Hong, Chunhua Qiao
Publikováno v:
SSRN Electronic Journal.
Tuberculosis (TB) is a leading infectious disease with serious antibiotic resistance. The benzothiazinone (BTZ) scaffold PBTZ169, an inhibitor of the decaprenylphosphoryl-β-D-ribose 2'-oxidase (DprE1) in Mycobacterium tuberculosis (Mtb), showed anti
Structural and Activity Relationships of 6-Sulfonyl-8-Nitrobenzothiazinones as Antitubercular Agents
Autor:
Chunhua Qiao, Yu Lu, Karin Savková, Rui Shi, Quanquan Han, Giovanni Stelitano, Stanislav Huszár, Dongguang Fan, Katarína Mikušová, Laurent R. Chiarelli, Bin Wang
Publikováno v:
Journal of medicinal chemistry. 64(19)
The benzothiazinone (BTZ) scaffold compound PBTZ169 kills Mycobacterium tuberculosis by inhibiting the essential flavoenzyme DprE1, consequently blocking the synthesis of the cell wall component arabinans. While extraordinarily potent against M. tube
Autor:
Zuzana Pakanová, Karin Savková, Michal Kaliňák, Martina Tesařová, Jana Korduláková, Marie Vancová, Stanislav Kozmon, Stanislav Huszár, Jaroslav Blaško, Peter Barath, Katarína Mikušová, Vinayak Singh
Publikováno v:
Proc Natl Acad Sci U S A
Mycobacterium tuberculosis, one of the deadliest pathogens in human history, is distinguished by a unique, multilayered cell wall, which offers the bacterium a high level of protection from the attacks of the host immune system. The primary structure