Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Katarína Hadová"'
Publikováno v:
Pharmaceutics, Vol 16, Iss 9, p 1139 (2024)
Semaglutide is a glucagon-like peptide 1 receptor (GLP-1R) agonist. GLP-1R agonists are used to treat type 2 diabetes and obesity. It is currently unknown whether semaglutide can directly increase force of contraction (FOC) in the human heart. We tes
Externí odkaz:
https://doaj.org/article/6a78d4276bc04006af37dc53873a16f3
Autor:
Katarina Hadova, Jana Kmecova, Katarina Ochodnicka‐Mackovicova, Eva Kralova, Gabriel Doka, Lenka Bies Pivackova, Peter Vavrinec, Tatiana Stankovicova, Peter Krenek, Jan Klimas
Publikováno v:
Pharmacology Research & Perspectives, Vol 11, Iss 5, Pp n/a-n/a (2023)
Abstract Drug‐induced long QT syndrome (LQTS) and Torsades de Pointes (TdP) are serious concerns in drug development. Although rats are a useful scientific tool, their hearts, unlike larger species, usually do not respond to torsadogenic drugs. Con
Externí odkaz:
https://doaj.org/article/acd81ddf7e3742c6866e49beb81f53fa
Autor:
Julius R. Herting, Jule H. König, Katarina Hadova, Alexander Heinick, Frank U. Müller, Paul Pauls, Matthias D. Seidl, Carolina Soppa, Uwe Kirchhefer
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
BackgroundThe activity, localization, and substrate specificity of the protein phosphatase 2A (PP2A) heterotrimer are controlled by various regulatory B subunits. PR72 belongs to the B'' gene family and has been shown to be upregulated in human heart
Externí odkaz:
https://doaj.org/article/0391b36d90b2486bb1c37216f3917b3b
Autor:
Julius R. Herting, Anna M. Berg, Katarina Hadova, Alexander Heinick, Simone König, Michael Kuhlmann, Frank U. Müller, Uwe Kirchhefer
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 3, Iss , Pp 100030- (2023)
Protein phosphatase 2A (PP2A) plays a central role in myocardial ischemia-reperfusion (I/R) injury. Several studies showed a detrimental function of PP2A by using either overexpression models of the catalytic subunit (PP2Ac) or exogenous inhibitors o
Externí odkaz:
https://doaj.org/article/5d5599b4e278488591046593677070c4
Autor:
Katarina Hadova, Eva Kralova, Gabriel Doka, Lenka Bies Pivackova, Zuzana Kmecova, Peter Krenek, Jan Klimas
Publikováno v:
BMC Cardiovascular Disorders, Vol 21, Iss 1, Pp 1-11 (2021)
Abstract Background In spite of disrupted repolarization of diabetic heart, some studies report less tendency of diabetic heart to develop ventricular arrhythmias suggesting effective compensatory mechanism. We hypothesized that myocardial alteration
Externí odkaz:
https://doaj.org/article/b014596872f240ebad66970d7b0c50da