Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Katalin Zboray"'
Autor:
Katalin Zboray, Adam V. Toth, Tímea D. Miskolczi, Krisztina Pesti, Emilio Casanova, Emanuel Kreidl, Arpad Mike, Áron Szenes, László Sági, Peter Lukacs
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Agriculturally important crop plants emit a multitude of volatile organic compounds (VOCs), which are excellent indicators of their health status and their interactions with pathogens and pests. In this study, we have developed a novel cellu
Externí odkaz:
https://doaj.org/article/bde1dc84b033479086f28e42e35f79aa
Autor:
Peter Lukacs, Krisztina Pesti, Mátyás C. Földi, Katalin Zboray, Adam V. Toth, Gábor Papp, Arpad Mike
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Standard high throughput screening projects using automated patch-clamp instruments often fail to grasp essential details of the mechanism of action, such as binding/unbinding dynamics and modulation of gating. In this study, we aim to demonstrate th
Externí odkaz:
https://doaj.org/article/a462ee9f768e4c7f87b1a2ff7d34f71f
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
We have developed an automated patch-clamp protocol that allows high information content screening of sodium channel inhibitor compounds. We have observed that individual compounds had their specific signature patterns of inhibition, which were manif
Externí odkaz:
https://doaj.org/article/c1551c4ded3940d3bc64b4db348dbef0
Autor:
Tamás Hegedűs, Katalin Zboray, Peter Lukacs, Arpad Mike, Krisztina Pesti, András Málnási-Csizmadia, Ádám Tóth, Mátyás C. Földi
Publikováno v:
British Journal of Pharmacology. 178:1200-1217
Background and purpose Sodium channel inhibitors can be used to treat hyperexcitability-related diseases, including epilepsies, pain syndromes, neuromuscular disorders and cardiac arrhythmias. The applicability of these drugs is limited by their nons
We have developed an automated patch-clamp protocol that allows high information content screening of sodium channel inhibitor compounds. We have observed that individual compounds had their specific signature patterns of inhibition, which were manif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::714be8d959525af40e706c29796dd165
https://doi.org/10.1101/2021.07.05.451191
https://doi.org/10.1101/2021.07.05.451191
An advanced automated patch clamp protocol design to investigate drug – ion channel binding dynamics
Autor:
Krisztina Pesti, Ádám Tóth, Mátyás C. Földi, Katalin Zboray, Gábor Papp, Peter Lukacs, Arpad Mike
Standard high throughput screening projects using automated patch-clamp instruments often fail to grasp essential details of the mechanism of action, such as binding/unbinding dynamics and modulation of gating. In this study, we aim to demonstrate th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0efe36a943b7c8f8a3a1afaded4852a2
https://doi.org/10.1101/2021.07.05.451189
https://doi.org/10.1101/2021.07.05.451189
Autor:
Fanni Sebák, Eszter Boros, András Micsonai, Gábor Pál, Andrea Bodor, József Kardos, Dávid Héja, Dávid Szakács, Katalin Zboray, Gitta Schlosser
Publikováno v:
Journal of Molecular Biology. 431:557-575
Reversible serine proteinase inhibitors comprise 18 unrelated families. Each family has a distinct representative structure but contains a surface loop that adopts the same, canonical conformation in the enzyme–inhibitor complex. The Laskowski mech
Publikováno v:
Biophysical Journal. 121:92a
Autor:
Arpad Mike, Krisztina Pesti, Tamás Hegedűs, Ádám Tóth, Katalin Zboray, Peter Lukacs, András Málnási-Csizmadia, Mátyás C. Földi
Hyperexcitability-related diseases include epilepsies, pain syndromes, neuromuscular disorders, and cardiac arrhythmias. Sodium channel inhibitors can be used to treat these conditions, however, their applicability is limited by their nonspecific eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::802c5d1ba026a51c9adcc1aba638e35d
https://doi.org/10.22541/au.159602491.14320115
https://doi.org/10.22541/au.159602491.14320115
Autor:
András Málnási-Csizmadia, Tamás Hegedus, Agnes K. Mike, Mátyás C. Földi, K. Pesti, Katalin Zboray, Peter Lukacs
Sodium channel inhibitor drugs can exert their effect by either blocking, or modulating the channel. The extent of modulation versus channel block is crucial regarding the therapeutic potential of drug candidates. Modulation can be selective for path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::facbf78674e1182470cf5da78b924dbc