Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Katalin Kariko"'
Autor:
David M Barrett, Daniel Martinez, Tiffany Smith, Jessica B Foster, Crystal Griffin, Jo Lynne Rokita, Allison Stern, Cameron Brimley, Komal Rathi, Maria V Lane, Samantha N Buongervino, Peter J Madsen, Alberto Delaidelli, Poul H Sorensen, Robert J Wechsler-Reya, Katalin Karikó, Phillip B Storm, Adam C Resnick, John M Maris, Kristopher R Bosse
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 9 (2022)
Background Pediatric brain tumors are the leading cause of cancer death in children with an urgent need for innovative therapies. Glypican 2 (GPC2) is a cell surface oncoprotein expressed in neuroblastoma for which targeted immunotherapies have been
Externí odkaz:
https://doaj.org/article/e7606fcfe47343a78a08e0f4943daef3
Autor:
Irena Vlatkovic, János Ludwig, Gábor Boros, Gábor Tamás Szabó, Julia Reichert, Maximilian Buff, Markus Baiersdörfer, Jonas Reinholz, Azita Josefine Mahiny, Uğur Şahin, Katalin Karikó
Publikováno v:
Pharmaceutics, Vol 14, Iss 2, p 328 (2022)
The presence of the cap structure on the 5′-end of in vitro-transcribed (IVT) mRNA determines its translation and stability, underpinning its use in therapeutics. Both enzymatic and co-transcriptional capping may lead to incomplete positioning of t
Externí odkaz:
https://doaj.org/article/fbb7c5e2512d47bd8ee8f47b5e147f52
Autor:
Ziyin Wang, Egon J. Jacobus, David C. Stirling, Stefanie Krumm, Katie E. Flight, Robert F. Cunliffe, Jonathan Mottl, Charanjit Singh, Lucy G. Mosscrop, Leticia Aragão Santiago, Annette B. Vogel, Katalin Kariko, Ugur Sahin, Stephanie Erbar, John S. Tregoning
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 34, Iss , Pp 102045- (2023)
The response to mRNA vaccines needs to be sufficient for immune cell activation and recruitment, but moderate enough to ensure efficacious antigen expression. The choice of the cap structure and use of N1-methylpseudouridine (m1Ψ) instead of uridine
Externí odkaz:
https://doaj.org/article/41e7361041324d99b26eb39f9bd0fb8e
Autor:
Katalin Karikó, Floris Rutjes
On 20 October 2022, the day that Radboud University celebrated its 99th anniversary, Dr. Katalin Karikó received a Radboud honorary doctorate in recognition of her scientific contributions to developing mRNA-based vaccines. This edition includes the
Autor:
Katalin Karikó
A powerful memoir from Katalin Karikó, winner of the 2023 Nobel Prize in Physiology or Medicine, whose decades-long research led to the COVID-19 vaccines “Katalin Karikó's story is an inspiration.”—Bill Gates“Riveting... a true story of a b
Autor:
Virna Cortez-Retamozo, Donald Shaffer, Katalin Karikó, Marie Bernardo, Timothy R Wagenaar, Hossam Hefesha, Mikhail Levit, Isaac Esparza, Ferdia Bates, Kerstin Andrea Heyl, Christian Hotz
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/faf6bfc237cf45199169736f084cc1bd
Publikováno v:
Stroke. 43
Background: Inflammation contributes to injury after intracerebral hemorrhage (ICH). We have previously demonstrated that activation of Toll-like receptor 4 (TLR4) on cells within the hemorrhage is a key initiator of the inflammatory response. TLR4-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::564d60529c44b3b148839b1123019434
https://doi.org/10.1161/str.43.suppl_1.a3822
https://doi.org/10.1161/str.43.suppl_1.a3822
Autor:
Dániel Szőke, Gábor Kovács, Éva Kemecsei, László Bálint, Kitti Szoták-Ajtay, Petra Aradi, Andrea Styevkóné Dinnyés, Barbara L. Mui, Ying K. Tam, Thomas D. Madden, Katalin Karikó, Raghu P. Kataru, Michael J. Hope, Drew Weissman, Babak J. Mehrara, Norbert Pardi, Zoltán Jakus
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Dysfunction of the lymphatic system leads to secondary lymphedema and results in degradation of quality of life. Here, the authors show that delivery of nucleoside-modified Vascular Endothelial Growth Factor C (VEGFC) mRNA, encapsulated in lipid nano
Externí odkaz:
https://doaj.org/article/e53077cda0b04c41bea9adf1cf679075
Autor:
Owen Daly, Azita Josefine Mahiny, Sara Majeski, Kevin McClintock, Julia Reichert, Gábor Boros, Gábor Tamás Szabó, Jonas Reinholz, Petra Schreiner, Steve Reid, Kieu Lam, Marlen Lepper, Melanie Adler, Tracy Meffen, James Heyes, Katalin Karikó, Pete Lutwyche, Irena Vlatkovic
Publikováno v:
Biomedicines, Vol 11, Iss 6, p 1735 (2023)
Argininosuccinic aciduria (ASA) is a metabolic disorder caused by a deficiency in argininosuccinate lyase (ASL), which cleaves argininosuccinic acid to arginine and fumarate in the urea cycle. ASL deficiency (ASLD) leads to hepatocyte dysfunction, hy
Externí odkaz:
https://doaj.org/article/25fe821524ea47a48910c484bef99572
Autor:
Norbert Pardi, Celia C. LaBranche, Guido Ferrari, Derek W. Cain, István Tombácz, Robert J. Parks, Hiromi Muramatsu, Barbara L. Mui, Ying K. Tam, Katalin Karikó, Patricia Polacino, Christopher J. Barbosa, Thomas D. Madden, Michael J. Hope, Barton F. Haynes, David C. Montefiori, Shiu-Lok Hu, Drew Weissman
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 15, Iss , Pp 36-47 (2019)
Despite the enormous effort in the development of effective vaccines against HIV-1, no vaccine candidate has elicited broadly neutralizing antibodies in humans. Thus, generation of more effective anti-HIV vaccines is critically needed. Here we charac
Externí odkaz:
https://doaj.org/article/f644ebace38a4334aa9e82c78e280dff