Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Katalin, Menyhart"'
Autor:
Katarina Zmajkovicova, Yasmina Bauer, Katalin Menyhart, Marie Schnoebelen, Diego Freti, Maxime Boucher, Bérengère Renault, Rolf Studer, Magdalena Birker-Robaczewska, Axel Klenk, Oliver Nayler, John Gatfield
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0228195 (2020)
Tissue fibrosis is a pathological condition characterized by uncontrolled fibroblast activation that ultimately leads to organ failure. The TGFβ1 pathway, one of the major players in establishment of the disease phenotype, is dependent on the transc
Externí odkaz:
https://doaj.org/article/282eb950f8d8439b83951dce674b541e
The Antifibrotic Activity of Prostacyclin Receptor Agonism Is Mediated through Inhibition of YAP/TAZ
Autor:
John Gatfield, Marie Schnoebelen, Katalin Menyhart, Katarina Zmajkovicova, Bérengère Renault, Matthias Bolinger, Rolf Studer, Yasmina Bauer, Oliver Nayler
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 60:578-591
Idiopathic pulmonary fibrosis is a life-threatening progressive disease characterized by loss of alveolar epithelial cells, inflammation, and aberrant fibroblast activation. The two currently approved therapies do not halt or reverse tissue remodelin
Autor:
Keith Morrison, Daniel Wanner, Marc Iglarz, Martine Clozel, Katalin Menyhart, John Gatfield, Carmela Gnerre, Oliver Nayler, Lucile Monnier, Patrick Hess
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 362:186-199
Prostacyclin (PGI2) receptor (IP receptor) agonists, which are indicated for the treatment of pulmonary arterial hypertension (PAH), increase cytosolic cAMP levels and thereby inhibit pulmonary vasoconstriction, pulmonary arterial smooth muscle cell
Autor:
John, Gatfield, Katalin, Menyhart, Daniel, Wanner, Carmela, Gnerre, Lucile, Monnier, Keith, Morrison, Patrick, Hess, Marc, Iglarz, Martine, Clozel, Oliver, Nayler
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 362(1)
Prostacyclin (PGI
Autor:
Patrick Hess, Gunther Schmidt, Katalin Menyhart, Daniel S. Strasser, Alexander Treiber, Claus Müller, Beat Steiner, Daniel Bur, Christopher Kohl, Roberto Bravo, Christoph Binkert, John Gatfield, Stephan Buchmann, Michael Scherz, Boris Mathys, Virginie Sippel, Stefan Abele, Martin Bolli, Oliver Nayler, Thomas Weller, Céline Mangold
Publikováno v:
Journal of Medicinal Chemistry. 53:4198-4211
Sphingosine-1-phosphate (S1P) is a widespread lysophospholipid which displays a wealth of biological effects. Extracellular S1P conveys its activity through five specific G-protein coupled receptors numbered S1P(1) through S1P(5). Agonists of the S1P
Autor:
John Gatfield, Katalin Menyhart, Matthias Bolinger, Rolf Studer, Katrin Sobel, Oliver Nayler, Lucile Monnier
Publikováno v:
Molecular pharmacology. 87(6)
FTY720 phosphate (FTY720-P; 2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol, monodihydrogen phosphate ester) is a nonselective sphingosine-1-phosphate (S1P) receptor agonist thought to be devoid of activity at the S1P2 receptor subtype. However, w
Autor:
Yasmina Bauer, Katrin Sobel, John Gatfield, Nina Killer, Katalin Menyhart, Rolf Studer, Beat Steiner, Martin Bolli, Oliver Nayler, Bérengère Renault
Publikováno v:
The Journal of biological chemistry. 288(21)
Synthetic sphingosine 1-phosphate receptor 1 modulators constitute a new class of drugs for the treatment of autoimmune diseases. Sphingosine 1-phosphate (S1P) signaling, however, is also involved in the development of fibrosis. Using normal human lu
Publikováno v:
Journal of the American College of Cardiology. (10):A1542
Prostacyclin receptor (IP receptor) agonists, which are used in the treatment of pulmonary arterial hypertension (PAH), increase cytosolic cAMP levels and thereby cause pulmonary vasodilation and inhibition of smooth muscle cell proliferation. Tachyp