Duplex DNA and BLM regulate gate opening by the human TopoIIIα-RMI1-RMI2 complex

Autor: Julia A. M. Bakx, Andreas S. Biebricher, Graeme A. King, Panagiotis Christodoulis, Kata Sarlós, Anna H. Bizard, Ian D. Hickson, Gijs J. L. Wuite, Erwin J. G. Peterman

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)

Here the authors probe the cleavage and gate opening of single-stranded DNA by the human topoisomerase TRR using a unique single-molecule strategy to reveal structural plasticity in response to both double-stranded DNA and the helicase BLM.

Externí odkaz: https://doaj.org/article/764b1c9c1010460d8e514df34cefdef4

Nonlinear mechanics of human mitotic chromosomes

Autor: Anna E C, Meijering, Kata, Sarlós, Christian F, Nielsen, Hannes, Witt, Janni, Harju, Emma, Kerklingh, Guus H, Haasnoot, Anna H, Bizard, Iddo, Heller, Chase P, Broedersz, Ying, Liu, Erwin J G, Peterman, Ian D, Hickson, Gijs J L, Wuite

Publikováno v: Nature. 605(7910)

In preparation for mitotic cell division, the nuclear DNA of human cells is compacted into individualized, X-shaped chromosomes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b2a94610fe20a58e8ab822d204595204
https://pubmed.ncbi.nlm.nih.gov/35999202

Reconstitution of anaphase DNA bridge recognition and disjunction

Autor: Mauro Modesti, Anna H. Bizard, Qi Yao, Anna G Ferreté-Bonastre, Kata Sarlós, Ian D. Hickson, Julia A M Bakx, Andreas S. Biebricher, Gijs J.L. Wuite, Erwin J.G. Peterman, Manikandan Paramasivam

Publikováno v: Sarlós, K, Biebricher, A S, Bizard, A H, Bakx, J A M, Ferreté-Bonastre, A G, Modesti, M, Paramasivam, M, Yao, Q, Peterman, E J G, Wuite, G J L & Hickson, I D 2018, ' Reconstitution of anaphase DNA bridge recognition and disjunction ', Nature Structural and Molecular Biology, vol. 25, no. 9, pp. 868-876 . https://doi.org/10.1038/s41594-018-0123-8
Nature Structural and Molecular Biology
Nature Structural and Molecular Biology, Nature Publishing Group, 2018, 25 (9), pp.868-876. ⟨10.1038/s41594-018-0123-8⟩
Nature Structural and Molecular Biology, 2018, 25 (9), pp.868-876. ⟨10.1038/s41594-018-0123-8⟩
Nature Structural and Molecular Biology, 25(9), 868-876. Nature Publishing Group
Nature Structural & Molecular Biology

International audience; Faithful chromosome segregation requires that the sister chromatids be disjoined completely. Defective disjunction can lead to the persistence of histone-free threads of DNA known as ultra-fine bridges (UFBs) that connect the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cf0fe7bef5227d07a61535d8c2d2699
https://doi.org/10.1038/s41594-018-0123-8

Knotty Problems during Mitosis

Autor: Kata Sarlós, Erwin J.G. Petermann, Andreas S. Biebricher, Gijs J.L. Wuite, Ian D. Hickson

Publikováno v: Cold Spring Harbor symposia on quantitative biology, 82, 187-195. Cold Spring Harbor Laboratory Press
Sarlós, K, Biebricher, A, Petermann, E J G, Wuite, G J L & Hickson, I D 2017, ' Knotty Problems during Mitosis : Mechanistic Insight into the Processing of Ultrafine DNA Bridges in Anaphase ', Cold Spring Harbor Laboratory. Symposia on Quantitative Biology, vol. 82, pp. 187-195 . https://doi.org/10.1101/sqb.2017.82.033647
Sarlós, K, Biebricher, A, Petermann, E J G, Wuite, G J L & Hickson, I D 2017, ' Knotty Problems during Mitosis : Mechanistic Insight into the Processing of Ultrafine DNA Bridges in Anaphase ', Cold Spring Harbor symposia on quantitative biology, vol. 82, pp. 187-195 . https://doi.org/10.1101/sqb.2017.82.033647

To survive and proliferate, cells have to faithfully segregate their newly replicated genomic DNA to the two daughter cells. However, the sister chromatids of mitotic chromosomes are frequently interlinked by so-called ultrafine DNA bridges (UFBs) th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c3d33433340331450f4412298b6a302
https://research.vu.nl/en/publications/98ac3f45-bc91-4b42-9849-b3a568d95a7c

Mutations in TOP3A Cause a Bloom Syndrome-like Disorder

Autor: Grainne S. Gorman, William P. Allen, Carol Anne Martin, Rebekah Jobling, Karen E. Heath, Amber Begtrup, Bernd Wollnik, N.S. Ali, Janine Altmüller, Hywel Williams, David A. Parry, Kei Murayama, J. Cruz-Rojo, Nursel Elcioglu, Anna H. Bizard, Yasushi Okazaki, Miriam Aza-Carmona, Fowzan S. Alkuraya, Massimo Bogliolo, Ian D. Hickson, Kata Sarlós, Clare V. Logan, Andrea Leitch, Gökhan Yigit, I Kesterton, Akira Ohtake, Anya Revah-Politi, Masaru Shimura, Roshan Singh Thakur, Jordi Surrallés, A.J. Malallah, Masakazu Kohda, Alejandro Iglesias, Yoshihito Kishita, Roser Pujol, Lesley Turner, Al-Owain, L. Zahavich, Robert W. Taylor, Peter Nürnberg, H.A.M. Dhahrabi, Megan T. Cho, Jimena Barraza-García, Andrew P. Jackson, María José Ramírez, Carolyn Wilson, B.A.Y. Barakat, P. Stevens, P. Le Quesne Stabej, Louise Cleal, Mehul T. Dattani

Publikováno v: American Journal of Human Genetics
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid

Bloom syndrome, caused by biallelic mutations in BLM, is characterized by prenatal-onset growth deficiency, short stature, an erythematous photosensitive malar rash, and increased cancer predisposition. Diagnostically, a hallmark feature is the prese

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0575f86bcaf71e46c26e873042bda13
https://pubmed.ncbi.nlm.nih.gov/30057030