Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Kasun Kodippili"'
Autor:
Kasun Kodippili, Chady H. Hakim, Matthew J. Burke, Yongping Yue, James A. Teixeira, Keqing Zhang, Gang Yao, Gopal J. Babu, Roland W. Herzog, Dongsheng Duan
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 2, Pp 101268- (2024)
Excessive cytosolic calcium accumulation contributes to muscle degeneration in Duchenne muscular dystrophy (DMD). Sarco/endoplasmic reticulum calcium ATPase (SERCA) is a sarcoplasmic reticulum (SR) calcium pump that actively transports calcium from t
Externí odkaz:
https://doaj.org/article/8999a19b16ac45ccb94ac3fd43620ab2
Autor:
Kasun Kodippili, Michael A. Rudnicki
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Progressive muscle weakness and degeneration characterize Duchenne muscular dystrophy (DMD), a lethal, x-linked neuromuscular disorder that affects 1 in 5,000 boys. Loss of dystrophin protein leads to recurrent muscle degeneration, progressive fibros
Externí odkaz:
https://doaj.org/article/ecae9cd0dc444a308ce921afeac29cc2
Autor:
Chady H. Hakim, Nathalie Clément, Lakmini P. Wasala, Hsiao T. Yang, Yongping Yue, Keqing Zhang, Kasun Kodippili, Laura Adamson-Small, Xiufang Pan, Joel S. Schneider, N. Nora Yang, Jeffrey S. Chamberlain, Barry J. Byrne, Dongsheng Duan
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss , Pp 664-678 (2020)
Vector production scale-up is a major barrier in systemic adeno-associated virus (AAV) gene therapy. Many scalable manufacturing methods have been developed. However, the potency of the vectors generated by these methods has rarely been compared with
Externí odkaz:
https://doaj.org/article/c9a8a753dbc949b9af502c5c8edc3335
Autor:
Chady H. Hakim, Nalinda B. Wasala, Xiufang Pan, Kasun Kodippili, Yongping Yue, Keqing Zhang, Gang Yao, Brittney Haffner, Sean X. Duan, Julian Ramos, Joel S. Schneider, N. Nora Yang, Jeffrey S. Chamberlain, Dongsheng Duan
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 6, Iss C, Pp 216-230 (2017)
Micro-dystrophins are highly promising candidates for treating Duchenne muscular dystrophy, a lethal muscle disease caused by dystrophin deficiency. Here, we report robust disease rescue in the severe DBA/2J-mdx model with a neuronal nitric oxide syn
Externí odkaz:
https://doaj.org/article/a968d82e3a484f8cb6cd48ebc8ad7bec
Autor:
Kasun Kodippili, Lauren Vince, Jin-Hong Shin, Yongping Yue, Glenn E Morris, Mark A McIntosh, Dongsheng Duan
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88280 (2014)
Epitope-specific monoclonal antibodies can provide unique insights for studying cellular proteins. Dystrophin is one of the largest cytoskeleton proteins encoded by 79 exons. The absence of dystrophin results in Duchenne muscular dystrophy (DMD). Ove
Externí odkaz:
https://doaj.org/article/d2d41421e1a34cada8d3bff5b2dc0bbd
Publikováno v:
Methods Mol Biol
Methods in Molecular Biology ISBN: 9781071626740
Methods in Molecular Biology ISBN: 9781071626740
Skeletal muscle is composed of long multinucleated cells, termed myofibers, that are formed through the activation and differentiation of resident muscle stem cells, called satellite cells. In healthy individuals, skeletal muscle enables voluntary lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e87aff1fb5db8d0ee3bbd443927cc6d2
https://europepmc.org/articles/PMC10204082/
https://europepmc.org/articles/PMC10204082/
Autor:
Dongsheng Duan, Yongping Yue, Lakmini P. Wasala, Xiufang Pan, Jeffrey S. Chamberlain, N. Nora Yang, Chady H. Hakim, Nathalie Clement, Joel S. Schneider, Keqing Zhang, Barry J. Byrne, Kasun Kodippili, Laura Adamson-Small, Hsiao T. Yang
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss, Pp 664-678 (2020)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Vector production scale-up is a major barrier in systemic adeno-associated virus (AAV) gene therapy. Many scalable manufacturing methods have been developed. However, the potency of the vectors generated by these methods has rarely been compared with
Autor:
Satvik Mareedu, Yimin Tian, Kasun Kodippili, Dongsheng Duan, Lai-Hua Xie, Antanina Voit, Gopal J. Babu, Nandita Niranjan, Nadezhda Fefelova
Publikováno v:
Am J Physiol Cell Physiol
Reduction in the expression of sarcolipin (SLN), an inhibitor of sarco(endo)plasmic reticulum (SR) Ca2+-ATPase (SERCA), ameliorates severe muscular dystrophy in mice. However, the mechanism by which SLN inhibition improves muscle structure remains un
Publikováno v:
J Pathol
Duchenne muscular dystrophy (DMD) is a muscle-wasting disease caused by dystrophin deficiency. Vascular dysfunction has been suggested as an underlying pathogenic mechanism in DMD. However, this has not been thoroughly studied in a large animal model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7712618003ebf63f2b3363454f8f4513
https://europepmc.org/articles/PMC8713812/
https://europepmc.org/articles/PMC8713812/
Autor:
Chady H. Hakim, Xiufang Pan, N. Nora Yang, Ronald L. Terjung, Dongsheng Duan, M. H. Laughlin, Kasun Kodippili, Hsiao T. Yang
Publikováno v:
The Journal of Physiology. 596:5199-5216
Key points We developed a novel method to study sympatholysis in dogs. We showed abolishment of sarcolemmal nNOS, and reduction of total nNOS and total eNOS in the canine Duchenne muscular dystrophy (DMD) model. We showed sympatholysis in dogs involv