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Genetic engineering of transfusable platelets with mRNA-lipid nanoparticles is compatible with blood banking practices.

Autor: Strong C; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada., Leung J; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; NanoMedicines Research Group, University of British Columbia, Vancouver, BC, Canada., Kang E; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada., Badior KE; Versiti Blood Research Institute, Milwaukee, WI., Robertson M; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; NanoMedicines Research Group, University of British Columbia, Vancouver, BC, Canada., Pereyra N; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada., Rowe EM; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada., Wietrzny A; Versiti Blood Research Institute, Milwaukee, WI., Ma B; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada., Noronha Z; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada., Arnold D; NanoVation Therapeutics, Vancouver, BC, Canada., Ciufolini MA; NanoVation Therapeutics, Vancouver, BC, Canada.; Department of Chemistry, University of British Columbia, Vancouver, BC, Canada., Devine DV; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada., Jan E; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada., Cullis PR; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada.; NanoMedicines Research Group, University of British Columbia, Vancouver, BC, Canada., Kastrup CJ; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada.; Centre for Blood Research, University of British Columbia, Vancouver, BC, Canada.; Versiti Blood Research Institute, Milwaukee, WI.; Departments of Surgery, Biochemistry, Biomedical Engineering, and Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI.

Publikováno v: Blood [Blood] 2024 Nov 21; Vol. 144 (21), pp. 2223-2236.

Regulation of hepatic inclusions and fibrinogen biogenesis by SEL1L-HRD1 ERAD.

Autor: Song Z; Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.; Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI, 48201, USA., Thepsuwan P; Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI, 48201, USA., Hur WS; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27514, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27514, USA.; UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27514, USA., Torres M; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48105, USA., Wu SA; Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Wei X; Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA., Tushi NJ; Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.; Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI, 48201, USA., Wei J; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.; Department of Cardiovascular Sciences and Center for Metabolic Disease Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA., Ferraresso F; Blood Research Institute, Versiti Blood Center of Wisconsin, Milwaukee, WI, 53226, USA.; Departments of Surgery, Biochemistry, Biomedical Engineering, and Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA., Paton AW; Research Centre for Infectious Diseases, Department of Molecular and Biomedical Science, University of Adelaide, Adelaide, South Australia, 5005, Australia., Paton JC; Research Centre for Infectious Diseases, Department of Molecular and Biomedical Science, University of Adelaide, Adelaide, South Australia, 5005, Australia., Zheng Z; Blood Research Institute, Versiti Blood Center of Wisconsin, Milwaukee, WI, 53226, USA.; Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, 53226, USA., Zhang K; Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI, 48201, USA., Fang D; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA., Kastrup CJ; Blood Research Institute, Versiti Blood Center of Wisconsin, Milwaukee, WI, 53226, USA.; Departments of Surgery, Biochemistry, Biomedical Engineering, and Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA., Jaiman S; Department of Pathology, Wayne State University School of Medicine, Detroit, MI, 48201, USA., Flick MJ; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27514, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27514, USA.; UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27514, USA., Sun S; Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA. bjk5fz@virginia.edu.; Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI, 48201, USA. bjk5fz@virginia.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Oct 26; Vol. 15 (1), pp. 9244. Date of Electronic Publication: 2024 Oct 26.