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Akademický článek

Regulation of hepatic inclusions and fibrinogen biogenesis by SEL1L-HRD1 ERAD

Autor: Zhenfeng Song, Pattaraporn Thepsuwan, Woosuk Steve Hur, Mauricio Torres, Shuangcheng Alivia Wu, Xiaoqiong Wei, Nusrat Jahan Tushi, Juncheng Wei, Francesca Ferraresso, Adrienne W. Paton, James C. Paton, Ze Zheng, Kezhong Zhang, Deyu Fang, Christian J. Kastrup, Sunil Jaiman, Matthew James Flick, Shengyi Sun

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Abstract Impaired secretion of an essential blood coagulation factor fibrinogen leads to hepatic fibrinogen storage disease (HFSD), characterized by the presence of fibrinogen-positive inclusion bodies and hypofibrinogenemia. However, the molecular m

Externí odkaz: https://doaj.org/article/44fed735e7da408086582af319824222

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Akademický článek

Saxitoxin potentiates human neuronal cell death induced by Zika virus while sparing neural progenitors and astrocytes

Autor: Leticia R. Q. Souza, Carolina G. da S. Pedrosa, Teresa Puig-Pijuan, Camila da Silva dos Santos, Gabriela Vitória, João M. A. Delou, Pedro Setti-Perdigão, Luiza M. Higa, Amilcar Tanuri, Stevens Kastrup Rehen, Marília Zaluar P. Guimarães

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)

Abstract The Zika virus (ZIKV) epidemic declared in Brazil between 2015 and 2016 was associated with an increased prevalence of severe congenital malformations, including microcephaly. The distribution of microcephaly cases was not uniform across the

Externí odkaz: https://doaj.org/article/d8dcaae1fcbd48feb4760630394c60cb

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Akademický článek

Landscape and challenges in economic evaluations of artificial intelligence in healthcare: a systematic review of methodology

Autor: Nanna Kastrup, Annette W. Holst-Kristensen, Jan B. Valentin

Publikováno v: BMC Digital Health, Vol 2, Iss 1, Pp 1-12 (2024)

Abstract Background The potential for artificial intelligence (AI) to transform healthcare cannot be ignored, and the development of AI technologies has increased significantly over the past decade. Furthermore, healthcare systems are under tremendou

Externí odkaz: https://doaj.org/article/5b51e0018e5c44a0892e29edefbb7fd7

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Akademický článek

Clinical development and proof of principle testing of new regenerative vascular endothelial growth factor-D therapy for refractory angina: rationale and design of the phase 2 ReGenHeart trial

Publikováno v: Open Heart, Vol 11, Iss 2 (2024)

Background Despite tremendous therapeutic advancements, a significant proportion of coronary artery disease patients suffer from refractory angina pectoris, that is, quality-of-life-compromising angina that is non-manageable with established pharmaco

Externí odkaz: https://doaj.org/article/568f4e4255744c448364960cbaf7874c

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Akademický článek

Protein is expressed in all major organs after intravenous infusion of mRNA-lipid nanoparticles in swine

Autor: Francesca Ferraresso, Katherine Badior, Monica Seadler, Youjie Zhang, Amanda Wietrzny, Massimo F. Cau, Amber Haugen, Geoffrey G. Rodriguez, Mitchell R. Dyer, Pieter R. Cullis, Eric Jan, Christian J. Kastrup

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 3, Pp 101314- (2024)

In vivo delivery of mRNA is promising for the study of gene expression and the treatment of diseases. Lipid nanoparticles (LNPs) enable efficient delivery of mRNA constructs, but protein expression has been assumed to be limited to the liver. With sp

Externí odkaz: https://doaj.org/article/0a01dff2207d42cfb668095ac39d3282

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Akademický článek

siRNA-mediated reduction of a circulating protein in swine using lipid nanoparticles

Autor: Massimo F. Cau, Francesca Ferraresso, Monica Seadler, Katherine Badior, Youjie Zhang, Laura M. Ketelboeter, Geoffrey G. Rodriguez, Taylor Chen, Matteo Ferraresso, Amanda Wietrzny, Madelaine Robertson, Amber Haugen, Pieter R. Cullis, Marc de Moya, Mitchell Dyer, Christian J. Kastrup

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 2, Pp 101258- (2024)

Genetic manipulation of animal models is a fundamental research tool in biology and medicine but is challenging in large animals. In rodents, models can be readily developed by knocking out genes in embryonic stem cells or by knocking down genes thro

Externí odkaz: https://doaj.org/article/81d09d224d2d4279aaec348f3d6c4563

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Akademický článek

Investigating the paracrine and juxtacrine abilities of adipose-derived stromal cells in angiogenesis triple cell co-cultures

Autor: Rebekka Harary Søndergaard, Lisbeth Drozd Højgaard, Mandana Haack-Sørensen, Cecilie Hoeeg, Ellen Mønsted Johansen, Bjarke Follin, Jens Kastrup, Annette Ekblond, Morten Juhl

Publikováno v: Stem Cell Research, Vol 77, Iss , Pp 103417- (2024)

The pro-angiogenic abilities of adipose-derived stromal cells (ASCs) make them attractive candidates for cellular therapy, especially for ischemic disease indications. However, details regarding the underlying mechanisms remain elusive. Therefore, th

Externí odkaz: https://doaj.org/article/4d899c4caf9d4799bb11d4eedef7e62b

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