Small-Molecule Degraders beyond PROTACs—Challenges and Opportunities

Autor: Kastl, Johanna M. ^*, Davies, Gareth, Godsman, Eleanor, Holdgate, Geoffrey A.

Publikováno v: In SLAS Discovery April 2021 26(4):524-533

A versatile framework for the analysis of high-throughput screening data

Autor: Hamecher, Johannes, Rieß, Thorsten, Bertini, Enrico, Kastl, Johanna Maria, Mayer, Thomas U., Merhof, Dorit, Kozak, Karol

Mitosis is an essential process within the cell life cycle, and research in this field has many applications in medicine. In order to study the proteins involved in mitosis and their function, small molecules (compounds) are required which inhibit th

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Small Molecule Approach to Study the Function of Mitotic Kinesins.

Autor: Al-Obaidi N; Department of Biology, Konstanz Research School Chemical Biology (KoRS-CB), University of Konstanz, Universitätsstr. 10, Konstanz, 78457, Germany., Kastl J; Department of Biology, Konstanz Research School Chemical Biology (KoRS-CB), University of Konstanz, Universitätsstr. 10, Konstanz, 78457, Germany., Mayer TU; Department of Biology, Konstanz Research School Chemical Biology (KoRS-CB), University of Konstanz, Universitätsstr. 10, Konstanz, 78457, Germany. thomas.u.mayer@uni-konstanz.de.

Publikováno v: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2016; Vol. 1413, pp. 283-99.