Preliminary Investigation of the Antibacterial Activity of Antitumor Drug 3-Amino-1,2,4-Benzotriazine-1,4-Dioxide (Tirapazamine) and its Derivatives

Autor: Evelina Polmickaitė-Smirnova, Jonas Šarlauskas, Kastis Krikštopaitis, Živilė Lukšienė, Zita Staniulytė, Žilvinas Anusevičius

Publikováno v: Applied Sciences, Vol 10, Iss 12, p 4062 (2020)

The antitumor drug 3-amino-1,2,4-benzotriazine-1,4-dioxide (tirapazamine, TPZ (1)) along with a number of newly synthesized tirapazamine derivatives (TPZs) bearing substitutions at the 3-amine position of TPZ (1) were estimated for their antibacteria

Externí odkaz: https://doaj.org/article/00b6d7faf6014048b796cdbce74ee316

Preliminary investigation of the antibacterial activity of antitumor drug 3-amino-1,2,4-benzotriazine-1,4-dioxide (tirapazamine) and its derivatives

Autor: Jonas Šarlauskas, Evelina Polmickaitė-Smirnova, Živilė Lukšienė, Žilvinas Anusevičius, Zita Staniulytė, Kastis Krikštopaitis

Publikováno v: Applied sciences, Basel : MDPI, 2020, vol. 10, iss. 12, art. no. 4062, p. [1-15]
Applied Sciences, Vol 10, Iss 4062, p 4062 (2020)
Applied Sciences
Volume 10
Issue 12

The antitumor drug 3-amino-1,2,4-benzotriazine-1,4-dioxide (tirapazamine, TPZ (1)) along with a number of newly synthesized tirapazamine derivatives (TPZs) bearing substitutions at the 3-amine position of TPZ (1) were estimated for their antibacteria

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::744a66fa628c51d8a5c846bdc27467ad
https://repository.vu.lt/VU:ELABAPDB80577691&prefLang=en_US

The study of NADPH-dependent flavoenzyme-catalyzed reduction of benzo[1,2-c]1,2,5-oxadiazole N-oxides (benzofuroxans)

Autor: Lina Misevičienė, Narimantas Čėnas, Aleksey Yantsevich, Audrius Laurynėnas, Laimonas Karvelis, Kastis Krikštopaitis, Audronė Marozienė, Jonas Šarlauskas, Žilvinas Anusevičius, Jonita Stankevičiūtė

Publikováno v: International Journal of Molecular Sciences
Volume 15
Issue 12
Pages 23307-23331
International journal of molecular sciences, Basel : MDPI AG, 2014, Vol. 15, iss. 12, p. 23307-23331
International Journal of Molecular Sciences, Vol 15, Iss 12, Pp 23307-23331 (2014)

The enzymatic reactivity of a series of benzo[1,2-c]1,2,5-oxadiazole N-oxides (benzofuroxans
BFXs) towards mammalian single-electron transferring NADPH:cytochrome P-450 reductase (P-450R) and two-electron (hydride) transferring NAD(P)H:quinone o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fec30be4f3821b86865d6db9e58fcd1c
https://pubmed.ncbi.nlm.nih.gov/25517035