Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients

Autor: Nissen, SEE, Lincoff, AM, Brennan, D, Ray, KKK, Mason, D, Kastelein, JJP, Thompson, PDD, Libby, P, Cho, L, Plutzky, J, Bays, HEE, Moriarty, PMM, Menon, V, Grobbee, DEE, Louie, MJJ, Chen, C-F, Li, N, Bloedon, LA, Robinson, P, Horner, M, Sasiela, WJJ, McCluskey, J, Davey, D, Fajardo-Campos, P, Petrovic, P, Fedacko, J, Zmuda, W, Lukyanov, Y, Nicholls, SJJ, CLEAR, OI

Publikováno v: The New England journal of medicine, 388(15), 1353-1364. Massachussetts Medical Society

BACKGROUND Bempedoic acid, an ATP citrate lyase inhibitor, reduces low-density lipoprotein (LDL) cholesterol levels and is associated with a low incidence of muscle-related adverse events; its effects on cardiovascular outcomes remain uncertain. METH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfe7dc6d498e4a119c3ada22c9dbe705
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Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

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C, Manning B, Woelcke J, Tan M, Manfreda S, Ponce T, Kam J, Saini R, Banker K, Salko T, Nandy P, Tawfik R, O’Neil G, Manne S, Jirvankar P, Lal S, Nema D, Jose J, Collins R, Bailey K, Blumenthal R, Colhoun H, Gersh B, Abreu M, Actis MV, Aiub J, Aiub F, Albisu J, Alvarisqueta A, Avalos V, Barreto M, Berli MA, Blumberg C, Bocanera M, Botta C, Bowen L, Budassi N, Buhlman S, Westberg JC, Carabajal T, Caruso G, Casala J, Cendali G, Coloma G, Berra FC, Cuneo C, Degennaro N, Dellasa M, Diaz M, Dos Santos P, Espinosa V, Facello A, Facello M, Farias E, Fernandez AA, Ferrari V, Pacora FF, Flores GS, Franco M, Gabito A, Viola HG, Garcia F, Garcia Duran R, Garcia Pinna J, Glenny J, Godoy Sanchez M, Grosse A, Guzman P, Hasbani E, Hominal M, Ibañez J, Jure H, Jure D, Vico ML, Liniado G, Luciardi H, Luquez H, Maehara G, Maffei L, Majul C, Mallagray M, Marinaro S, Martinez J, Massaccesi R, De Los Milagros Had M, Azize GM, Montana O, Montenegro E, Morell Y, Muntaner J, Navarrete S, Olmedo M, Paganini M, 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Publikováno v: Paediatrics Publications
New England journal of medicine, 377(12), 1119-1131. Massachussetts Medical Society

Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conduc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9352d7ff99dee51001e96d9b05970fb
https://doi.org/10.1056/nejmoa1707914

Effect of Serial Infusions of CER-001, a Pre-β High-Density Lipoprotein Mimetic on Coronary Atherosclerosis in Patients Following Acute Coronary Syndromes: The CARAT Trial

Autor: Nicholls, SJ, Andrews, J, Kastelein, JJP, Merkely, B, Nissen, SE, Ray, KK, Schwartz, GG, Worthley, SG, Keyserling, C, Dasseux, J-L, Griffith, L, Kim, SW, Janssan, A, Di Giovanni, G, Pisaniello, AD, Scherer, DJ, Psaltis, P, Butters, J

Background: CER - 001 is a negatively charged, engineered pre -  HDL mimetic containing apolipoprotein A - I and sphingomyelin. Preliminary studies demonstrated favorable effects of CER - 001 on cholesterol efflux and vascular inflammation. In a p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::c9ab0ee9744d332f4993c750c70f0093
http://hdl.handle.net/10044/1/61066

Inclisiran in patients with high CV risk and elevated LDL-cholesterol

Autor: Ray, KK, Landmesser, U, Leiter, LA, Kallend, D, Dufour, R, Karakas, M, Hall, T, Troquay, RPT, Turner, T, Visseren, FLJ, Wijngaard, P, Wright, RS, Kastelein, JJP

BACKGROUND In a previous study, a single injection of inclisiran, a chemically synthesized small interfering RNA designed to target PCSK9 messenger RNA, was found to produce sustained reductions in low-density lipoprotein (LDL) cholesterol levels ove

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::22b4d95d3bc71510a52a882f324ac47e
http://hdl.handle.net/10044/1/45416

Determining When to Add Nonstatin Therapy: A Quantitative Approach

Autor: Robinson, JG, Huijgen, R, Ray, KK, Persons, J, Kastelein, JJP, Pencina, MJ

Publikováno v: Journal of the American College of Cardiology, 68(22), 2412-2421. Elsevier USA

Background: Nonstatin costs and uncertainty about benefits currently limit their use. Estimation of the potential for net benefit may better guide the addition of nonstatin therapy. Objective: Identify groups of patients who might benefit from the ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::e5f9f45cb8eb04c1c1533bf1402db928
https://pure.amc.nl/en/publications/determining-when-to-add-nonstatin-therapy-a-quantitative-approach(2c8c722a-ca60-45cf-b103-3fb4ad53f249).html