Bayesian meta-analysis of inter-phenotypic differences in human serum paraoxonase-1 activity for chemical risk assessment

Autor: Darney, K., Kasteel, E. E.J., Buratti, F. M., Turco, L., Vichi, S., Béchaux, C., Roudot, A. C., Kramer, N. I., Testai, E., Dorne, J. L.C.M., Di Consiglio, E., Lautz, L. S., LS IRAS Tox CMT/ATX, IRAS OH Toxicology, dIRAS RA-1, One Health Pharma

Publikováno v: Environment International
Environment International, Elsevier, 2020, 138, pp.105609-. ⟨10.1016/j.envint.2020.105609⟩
Environment international, 138. Elsevier Limited
Environment International, Vol 138, Iss, Pp-(2020)

Human variability in paraoxonase-1 (PON1) activities is driven by genetic polymorphisms that affect the internal dose of active oxons of organophosphorus (OP) insecticides. Here, an extensive literature search has been performed to collect human geno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::003550e846d0d714e189c9e37b7b322d
https://dspace.library.uu.nl/handle/1874/408983

Human variability in isoform-specific UDP-glucuronosyltransferases: markers of acute and chronic exposure, polymorphisms and uncertainty factors

Autor: Kasteel, E. E.J., Darney, K., Kramer, N. I., Dorne, J. L.C.M., Lautz, L. S., LS IRAS Tox CMT/ATX, IRAS OH Toxicology, dIRAS RA-1, One Health Pharma

Publikováno v: Archives of Toxicology
Archives of Toxicology, 94, 2637. Springer Verlag

UDP-glucuronosyltransferases (UGTs) are involved in phase II conjugation reactions of xenobiotics and differences in their isoform activities result in interindividual kinetic differences of UGT probe substrates. Here, extensive literature searches w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56417a6bee3b2e2b11b9ea58587a7ca9
https://doi.org/10.1007/s00204-020-02765-8

Bayesian meta-analysis of inter-phenotypic differences in human serum paraoxonase-1 activity for chemical risk assessment.

Autor: Darney K; Risk Assessment Department, French Agency for Food, Environmental and Occupational Health & Safety (ANSES), 14 rue Pierre et Marie Curie, Maisons-Alfort F-94700, France., Kasteel EEJ; Institute for Risk Assessment Sciences, Utrecht University, 3508 TD Utrecht, the Netherlands., Buratti FM; Department of Environment and Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy., Turco L; Department of Environment and Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy., Vichi S; Department of Environment and Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy., Béchaux C; Risk Assessment Department, French Agency for Food, Environmental and Occupational Health & Safety (ANSES), 14 rue Pierre et Marie Curie, Maisons-Alfort F-94700, France., Roudot AC; Laboratoire des Interactions Epithéliums Neurones, Université Bretagne Loire (UBL), UFR Sciences et Techniques, 6 Av. Victor Le Gorgeu, CS93837, Cedex 3, Brest 29238, France., Kramer NI; Institute for Risk Assessment Sciences, Utrecht University, 3508 TD Utrecht, the Netherlands., Testai E; Department of Environment and Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy., Dorne JLCM; European Food Safety Authority, 1a, Via Carlo Magno 1A, 43126 Parma, Italy., Di Consiglio E; Department of Environment and Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy., Lautz LS; Risk Assessment Department, French Agency for Food, Environmental and Occupational Health & Safety (ANSES), 14 rue Pierre et Marie Curie, Maisons-Alfort F-94700, France. Electronic address: leonie.lautz@anses.fr.

Publikováno v: Environment international [Environ Int] 2020 May; Vol. 138, pp. 105609. Date of Electronic Publication: 2020 Feb 27.