Mechanistic insight into RET kinase inhibitors targeting the DFG-out conformation in RET-rearranged cancer

Autor: Plenker, D., Riedel, M., Brägelmann, J., Dammert, M. A., Chauhan, R., Knowles, P. P., Lorenz, C., Keul, M., Bührmann, M., Pagel, O., Tischler, V., Scheel, A. H., Schütte, D., Song, Y., Stark, J., Mrugalla, F., Alber, Y., Richters, A., Engel, J., Leenders, F., Heuckmann, J. M., Wolf, J., Diebold, J., Pall, G., Peifer, M., Aerts, M., Gevaert, K., Zahedi, R. P., Buettner, R., Shokat, K. M., McDonald, N. Q., Kast, S. M., Gautschi, O., Thomas, R. K., Sos, M. L.

Oncogenic fusion events have been identified in a broad range of tumors. Among them, RET rearrangements represent distinct and potentially druggable targets that are recurrently found in lung adenocarcinomas. Here, we provide further evidence that cu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::13a16b1b54b8df448aafd5f8beab979a
https://eprints.bbk.ac.uk/id/eprint/18406/1/aah6144_CombinedPDF_v3.pdf

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Parametrization Strategy for the MolFESD Concept:  Quantitative Surface Representation of Local Hydrophobicity

Autor: Jager, R., Kast, S. M., Brickmann, J.

Publikováno v: Journal of Chemical Information and Computer Sciences (now called Journal of Chemical Information and Modeling); January 2003, Vol. 43 Issue: 1 p237-247, 11p

Quantum/Classical Investigation of Amide Protonation in Aqueous Solution

Autor: Zahn, D., Schmidt, K. F., Kast, S. M., Brickmann, J.

Publikováno v: The Journal of Physical Chemistry - Part A; August 2002, Vol. 106 Issue: 34 p7807-7812, 6p

Fast prediction of hydration free energies from molecular interaction fields

Autor: Jager, R., Kast, S. M.

Publikováno v: Journal of Molecular Graphics and Modelling; 2001, Vol. 20 Issue: 2 p123-131, 9p