Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Kassi T. Stein"'
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 9, p e1008202 (2020)
Hydrogen peroxide (H2O2) promotes a range of phenotypes depending on its intracellular concentration and dosing kinetics, including cell death. While this qualitative relationship has been well established, the quantitative and mechanistic aspects of
Externí odkaz:
https://doaj.org/article/e94eb91d5e5a445ba66241a27cefa7dd
Autor:
Annette Shepard-Barry, Karel Pacak, Inna Lomakin, James F. Powers, Sun Jin Moon, Troy F. Langford, Yingbin Ouyang, Arthur S. Tischler, Brent H. Cochran, Richard W. Tothill, Hadley D. Sikes, Kassi T. Stein, Xue Zhang, James D. Baleja, Andrew D Pattison
Publikováno v:
Endocrine-Related Cancer
Tumors caused by loss-of-function mutations in genes encoding TCA cycle enzymes have been recently discovered and are now of great interest. Mutations in succinate dehydrogenase (SDH) subunits cause pheochromocytoma/paraganglioma (PCPG) and syndromic
Autor:
Xue Zhang, Troy F. Langford, James D. Baleja, Hadley D. Sikes, Inna Lomakin, James F. Powers, Arthur S. Tischler, Kassi T. Stein, Brent H. Cochran
Publikováno v:
PMC
We describe a unique patient-derived xenograft (PDX) and cell culture model of succinate dehydrogenase-deficient gastrointestinal stromal tumor (SDH-deficient GIST), a rare mesenchymal tumor that can occur in association with paragangliomas in heredi
Publikováno v:
ACS Synthetic Biology. 7:2037-2044
Among reactive oxygen species (ROS), H2O2 alone acts as a signaling molecule that promotes diverse phenotypes depending on the intracellular concentration. Mitochondria have been suggested as both sources and sinks of cellular H2O2, and mitochondrial
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 16, Iss 9, p e1008202 (2020)
PLoS Computational Biology, Vol 16, Iss 9, p e1008202 (2020)
Hydrogen peroxide (H2O2) promotes a range of phenotypes depending on its intracellular concentration and dosing kinetics, including cell death. While this qualitative relationship has been well established, the quantitative and mechanistic aspects of
Publikováno v:
ACS Synthetic Biology. 5:1389-1395
Reactive oxygen species (ROS) such as H2O2 play paradoxical roles in mammalian physiology. It is hypothesized that low, baseline levels of H2O2 are necessary for growth and differentiation, while increased intracellular H2O2 concentrations are associ
Interpreting Heterogeneity in Response of Cells Expressing a Fluorescent Hydrogen Peroxide Biosensor
Publikováno v:
Biophysical Journal. 109:2148-2158
Fluorescent, genetically encoded sensors of hydrogen peroxide have enabled visualization of perturbations to the intracellular level of this signaling molecule with subcellular and temporal resolution. Ratiometric sensors hold the additional promise
Publikováno v:
ACS synthetic biology. 7(9)
Among reactive oxygen species (ROS), H
Autor:
Kassi T. Stein, Noreen F. Rizvi, Miglia Cornejo, Carolyn W. T. Lee-Parsons, Jessica D. Weaver, Erin J. Cram
Publikováno v:
Plant Cell, Tissue and Organ Culture (PCTOC). 120:475-487
Efficient genetic engineering of the medicinal plant, Catharanthus roseus, is essential in improving the production of the pharmaceutically important anticancer compounds, vinblastine and vincristine. Here we optimize several steps in the Agrobacteri
Autor:
Stein, Kassi T.1 (AUTHOR), Moon, Sun Jin1 (AUTHOR), Nguyen, Athena N.2 (AUTHOR), Sikes, Hadley D.1 (AUTHOR) sikes@mit.edu
Publikováno v:
PLoS Computational Biology. 9/14/2020, Vol. 16 Issue 9, p1-21. 21p. 1 Color Photograph, 2 Diagrams, 5 Charts, 3 Graphs.