Complementary dual-virus strategy drives synthetic target and cognate T-cell engager expression for endogenous-antigen agnostic immunotherapy.

Autor: Taha Z; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada. ztaha053@uottawa.ca.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada. ztaha053@uottawa.ca., Crupi MJF; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada. mcrupi@ohri.ca.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada. mcrupi@ohri.ca., Alluqmani N; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada., MacKenzie D; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Vallati S; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada., Whelan JT; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada., Fareez F; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada., Alwithenani A; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada., Petryk J; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Chen A; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Spinelli MM; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Ng K; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Sobh J; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., de Souza CT; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Bharadwa PR; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada., Lee TKH; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada., Thomas DA; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada., Huang BZ; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada., Kassas O; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Poutou J; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Gilchrist VH; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada., Boulton S; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Thomson M; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Marius R; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Hooshyar M; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., McComb S; Cancer Immunology Team, National Research Council of Canada, Human Health Therapeutics, Ottawa, ON, K1A 0R6, Canada., Arulanandam R; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada., Ilkow CS; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada., Bell JC; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada. jbell@ohri.ca.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada. jbell@ohri.ca., Diallo JS; Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8L6, Canada. jsdiallo@ohri.ca.; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, K1H 8M5, Canada. jsdiallo@ohri.ca.

Publikováno v: Nature communications [Nat Commun] 2024 Aug 23; Vol. 15 (1), pp. 7267. Date of Electronic Publication: 2024 Aug 23.

Developing the Mansoura Early Feeding Skills Assessment Scale for Preterm Infants.

Autor: El-Kassas O; Department of Otorhinolaryngology, Faculty of Medicine, Mansoura University, Mansoura, Egypt., Amer A; Department of Otorhinolaryngology, Faculty of Medicine, Mansoura University, Mansoura, Egypt., Abdel-Hady H; Department of Pediatric, Faculty of Medicine, Mansoura University, Mansoura, Egypt., Abou-Elsaad T; Department of Otorhinolaryngology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Publikováno v: Pediatric gastroenterology, hepatology & nutrition [Pediatr Gastroenterol Hepatol Nutr] 2023 Nov; Vol. 26 (6), pp. 320-337. Date of Electronic Publication: 2023 Oct 30.

Oncolytic virus driven T-cell-based combination immunotherapy platform for colorectal cancer.

Autor: Crupi MJF; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada., Taha Z; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada., Janssen TJA; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Petryk J; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Boulton S; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada., Alluqmani N; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada., Jirovec A; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada., Kassas O; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Khan ST; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Vallati S; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada., Lee E; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Huang BZ; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Huh M; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Discovery Research, Turnstone Biologics Inc, Ottawa, ON, Canada., Pikor L; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.; Discovery Research, Turnstone Biologics Inc, Ottawa, ON, Canada., He X; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Marius R; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Austin B; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada., Duong J; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.; Discovery Research, Turnstone Biologics Inc, Ottawa, ON, Canada., Pelin A; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.; Discovery Research, Turnstone Biologics Inc, Ottawa, ON, Canada., Neault S; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada., Azad T; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada., Breitbach CJ; Discovery Research, Turnstone Biologics Inc, Ottawa, ON, Canada., Stojdl DF; Discovery Research, Turnstone Biologics Inc, Ottawa, ON, Canada., Burgess MF; Discovery Research, Turnstone Biologics Inc, Ottawa, ON, Canada., McComb S; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.; Human Health Therapeutics Research Centre, National Research Council, Ottawa, ON, Canada., Auer R; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada., Diallo JS; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada., Ilkow CS; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada., Bell JC; Centre for Innovative Cancer Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.

Publikováno v: Frontiers in immunology [Front Immunol] 2022 Nov 03; Vol. 13, pp. 1029269. Date of Electronic Publication: 2022 Nov 03 (Print Publication: 2022).

Engineering Rapalog-Inducible Genetic Switches Based on Split-T7 Polymerase to Regulate Oncolytic Virus-Driven Production of Tumour-Localized IL-12 for Anti-Cancer Immunotherapy.

Autor: Martin, Nikolas T.^1,2 (AUTHOR), Crupi, Mathieu J. F.^1,2 (AUTHOR), Taha, Zaid^1,2 (AUTHOR), Poutou, Joanna^1,2 (AUTHOR), Whelan, Jack T.^1,2 (AUTHOR), Vallati, Sydney^1,2 (AUTHOR), Petryk, Julia¹ (AUTHOR), Marius, Ricardo¹ (AUTHOR), Austin, Bradley¹ (AUTHOR), Azad, Taha^1,2 (AUTHOR), Boulanger, Mason¹ (AUTHOR), Burgess, Tamara¹ (AUTHOR), Sanders, Ilson¹ (AUTHOR), Victoor, Camille¹ (AUTHOR), Dickinson, Bryan C.³ (AUTHOR), Diallo, Jean-Simon^1,2 (AUTHOR), Ilkow, Carolina S.^1,2 (AUTHOR), Bell, John C.^1,2 (AUTHOR) jbell@ohri.ca

Publikováno v: Pharmaceuticals (14248247). May2023, Vol. 16 Issue 5, p709. 23p.

Calcium silicate‐reinforced pH‐sensitive alginate‐gellan gum composite hydrogels for prolonged drug delivery.

Autor: Panday, Anupama, Yadav, Harsh, Patel, Jwala, Paliwal, Rishi, Maiti, Sabyasachi

Publikováno v: Journal of Applied Polymer Science; 10/5/2023, Vol. 140 Issue 37, p1-13, 13p