Allogeneic Stem Cell Transplantation Platforms With Ex Vivo and In Vivo Immune Manipulations: Count and Adjust

Autor: Moniek de Witte, Laura G. M. Daenen, Lotte van der Wagen, Anna van Rhenen, Reiner Raymakers, Kasper Westinga, Jürgen Kuball

Publikováno v: HemaSphere, Vol 5, Iss 6, p e580 (2021)

Various allogeneic (allo) stem cell transplantation platforms have been developed over the last 2 decades. In this review we focus on the impact of in vivo and ex vivo graft manipulation on immune reconstitution and clinical outcome. Strategies inclu

Externí odkaz: https://doaj.org/article/3f36b76bc11f454ca155290f0fa242a7

Results of a multicenter phase I/II trial of TCRαβ and CD19-depleted haploidentical hematopoietic stem cell transplantation for adult and pediatric patients

Autor: Wolfgang A. Bethge, Matthias Eyrich, Stephan Mielke, Roland Meisel, Dietger Niederwieser, Paul G. Schlegel, Ansgar Schulz, Johann Greil, Donald Bunjes, Arne Brecht, Jurgen Kuball, Michael Schumm, Vladan Vucinic, Markus Wiesneth, Halvard Bonig, Kasper Westinga, Stefanie Biedermann, Silke Holtkamp, Sandra Karitzky, Michaela Malchow, Christiane Siewert, Rupert Handgretinger, Peter Lang

Publikováno v: Bone Marrow Transplantation

Hematopoietic stem cell transplantation (HSCT) from haploidentical donors is a viable option for patients lacking HLA-matched donors. Here we report the results of a prospective multicenter phase I/II trial of transplantation of TCRαβ and CD19-depl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d15987cc42b231ca9a41cc88cf8bd20
https://pubmed.ncbi.nlm.nih.gov/34952929

Alpha beta T-cell graft depletion for allogeneic HSCT in adults with hematological malignancies

Autor: Trudy Straetemans, Froso Karaiskaki, Anna van Rhenen, Constantijn J.M. Halkes, Lotte van der Wagen, Monique C. Minnema, Anke Janssen, Klaartje Nijssen, Luuk Swanenberg, Jürgen Kuball, Reinier Raymakers, Moniek A. de Witte, Eefke Petersen, Rick Admiraal, Jaap-Jan Boelens, Kasper Westinga

Publikováno v: Blood Adv
Blood Advances, 5(1), 240-249. AMER SOC HEMATOLOGY

We conducted a multicenter prospective single-arm phase 1/2 study that assesses the outcome of αβ T-cell depleted allogeneic hematopoietic stem cell transplantation (allo-HSCT) of peripheral blood derived stem cells from matched related, or unrelat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ec74445db1f4332a6b4485b2127edfd
https://hdl.handle.net/1887/3279607

Efficacy of MSC for steroid-refractory acute GVHD associates with MSC donor age and a defined molecular profile

Autor: Colin de Haar, Kasper Westinga, Mette D. Hazenberg, Caroline A. Lindemans, Sanne van Dooremalen, Rick Admiraal, Lotte van der Wagen, Jürgen Kuball, Magdalena J. Lorenowicz, Anke Janssen, Jaap Jan Boelens, Walter J.F.M. van der Velden, Febilla Fernando, Nagesha Appukudige, Rien van Marwijk Kooy, Annoek E.C. Broers, Jeroen Janssen, Gerwin Huls, Alberto Miranda-Bedate

Publikováno v: Bone Marrow Transplantation, 55, 2188-2192
Bone Marrow Transplantation, 55(11), 2188-2192. Nature Publishing Group
Bone marrow transplantation, 55(11), 2188-2192. Nature Publishing Group
van der Wagen, L E, Miranda-Bedate, A, Janssen, A, Fernando, F, Appukudige, N, van Dooremalen, S, Westinga, K, Admiraal, R, Lorenowicz, M J, Huls, G, Janssen, J J W M, Broers, A E C, van der Velden, W J F M, van Marwijk Kooy, R, Hazenberg, M D, de Haar, C, Lindemans, C, Jan Boelens, J & Kuball, J 2020, ' Efficacy of MSC for steroid-refractory acute GVHD associates with MSC donor age and a defined molecular profile ', Bone Marrow Transplantation, vol. 55, no. 11, pp. 2188-2192 . https://doi.org/10.1038/s41409-020-0910-9
Bone Marrow Transplantation, 55, 11, pp. 2188-2192

Contains fulltext : 229413.pdf (Publisher’s version ) (Closed access)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b48fc123a55f88a9f68c16049df95b
http://hdl.handle.net/2066/229413

Efficacy of host-dendritic cell vaccinations with or without minor histocompatibility antigen loading, combined with donor lymphocyte infusion in multiple myeloma patients

Autor: Tineke Aarts, Ineke Slaper-Cortenbach, H M Lokhorst, Monique C. Minnema, Maarten E. Emmelot, Ruud Doorn, Kasper Westinga, Els Goulmy, Laurens E. Franssen, Tuna Mutis, Eric Spierings, Evelien Kneppers, Rimke Oostvogels

Publikováno v: Oostvogels, R, Kneppers, E, Minnema, M C, Doorn, R C, Franssen, L E, Aarts, T, Emmelot, M E, Spierings, E, Slaper-Cortenbach, I, Westinga, K, Goulmy, E, Lokhorst, H M & Mutis, T 2016, ' Efficacy of host-dendritic cell vaccinations with or without minor histocompatibility antigen loading, combined with donor lymphocyte infusion in multiple myeloma patients ', Bone Marrow Transplantation . https://doi.org/10.1038/bmt.2016.250
Bone Marrow Transplantation. Nature Publishing Group
Bone Marrow Transplantation, 52, 228–237. Nature Publishing Group

Donor lymphocyte infusions (DLI) can induce durable remissions in multiple myeloma (MM) patients, but this occurs rather infrequently. As the graft-versus-tumor (GvT) effect of DLI depends on the presence of host-dendritic cells (DCs), we tested in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dcc8be0583aa4098d98f312aa49e05e
https://doi.org/10.1038/bmt.2016.250