The birth weight lowering C-allele of rs900400 near LEKR1 and CCNL1 associates with elevated insulin release following an oral glucose challenge.

Autor: Ehm A Andersson, Marie N Harder, Kasper Pilgaard, Charlotta Pisinger, Alena Stančáková, Johanna Kuusisto, Niels Grarup, Kristine Færch, Pernille Poulsen, Daniel R Witte, Torben Jørgensen, Allan Vaag, Markku Laakso, Oluf Pedersen, Torben Hansen

Publikováno v: PLoS ONE, Vol 6, Iss 11, p e27096 (2011)

BACKGROUND AND AIM:The first genome-wide association study on birth weight was recently published and the most significant associated birth weight lowering variant was the rs900400 C-allele located near LEKR1 and CCNL1. We aimed to replicate the asso

Externí odkaz: https://doaj.org/article/763c3b3b4ed24e0eb618ee805ee4f94b

Leukocyte telomere length is associated with elevated plasma glucose and HbA1c in young healthy men independent of birth weight

Autor: Louise G. Grunnet, Amra Ciric Alibegovic, Allan Vaag, Camilla B. Jensen, Kasper Pilgaard, Charlotte Brøns, Martin R. Bennett, Susan E. Ozanne, Line Hjort

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
Grunnet, L G, Pilgaard, K, Alibegovic, A, Jensen, C B, Hjort, L, Ozanne, S E, Bennett, M, Vaag, A & Brøns, C 2019, ' Leukocyte telomere length is associated with elevated plasma glucose and HbA1c in young healthy men independent of birth weight ', Scientific Reports, vol. 9, no. 1, 7639 . https://doi.org/10.1038/s41598-019-43387-0
Scientific Reports

Telomeres are protein-bound regions of repetitive nucleotide sequences (TTAGGG) at the end of human chromosomes, and their length is a marker of cellular aging. Intrauterine growth restriction is associated with shorter blood cell telomeres at birth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af962f1852582e48ecc0feabfd8645ff

Link Between GIP and Osteopontin in Adipose Tissue and Insulin Resistance

Autor: Peter Osmark, Bilal Omar, Leif Groop, Alena Stančáková, Tiina Kuulasmaa, Emma Ahlqvist, Kasper Pilgaard, Bo Isomaa, Valeriya Lyssenko, Nils Wierup, Eva Degerman, Jussi Pihlajamäki, Tiinamaija Tuomi, Allan Vaag, Johanna Kuusisto, Anna Jonsson, Olga Kotova, Maria F. Gomez, Sten Madsbad, Ola Hansson, Pernille Poulsen, Anna V. Zetterqvist, Timothy J. Kieffer, Charlotte Brøns, Markku Laakso

Publikováno v: Diabetes; Vol 62
Diabetes

Low-grade inflammation in obesity is associated with accumulation of the macrophage-derived cytokine osteopontin (OPN) in adipose tissue and induction of local as well as systemic insulin resistance. Since glucose-dependent insulinotropic polypeptide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54e7f12c70b0b166451364c907f8956c

Low birthweight and premature birth are both associated with type 2 diabetes in a random sample of middle-aged Danes

Autor: Pernille Poulsen, Torben Hansen, Kristine Færch, Kasper Pilgaard, Bendix Carstensen, Torben Jørgensen, Allan Vaag, Daniel R. Witte, Charlotta Pisinger, Oluf Pedersen

Publikováno v: Pilgaard, K, Færch, K, Carstensen, B, Poulsen, P, Pisinger, C, Pedersen, O, Witte, D R, Hansen, T, Jørgensen, T & Vaag, A 2010, ' Low birthweight and premature birth are both associated with type 2 diabetes in a random sample of middle-aged Danes ', Diabetologia, vol. 53, no. 12, pp. 2526-30 . https://doi.org/10.1007/s00125-010-1917-3
Pilgaard, K, Færch, K, Carstensen, B, Poulsen, P, Pisinger, C, Pedersen, O, Witte, D R, Hansen, T, Jørgensen, T & Vaag, A 2010, ' Low birthweight and premature birth are both associated with type 2 diabetes in a random sample of middle-aged Danes ', Diabetologia, vol. 53, no. 12, pp. 2526-2530 . https://doi.org/10.1007/s00125-010-1917-3

We studied the associations of size at birth and prematurity with type 2 diabetes, insulin sensitivity and beta cell function in the Danish population-based Inter99 study (ClinicalTrials.gov NCT00289237).Information about size at birth and prematurit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::127f8178ceb3fa7a805cce3af155925c
https://doi.org/10.1007/s00125-010-1917-3

Increased Risk of Type 2 Diabetes in Elderly Twins

Autor: Kasper Pilgaard, Henning Beck-Nielsen, Heidi Storgaard, Pernille Poulsen, Mette P. Sonne, Amra AlibegovicA. Alibegovic, Louise G. Grunnet, Allan Vaag, Bendix Carstensen

Publikováno v: Diabetes
Poulsen, P, Grunnet, L G, Pilgaard, K, Storgaard, H, Alibegovic, A, Sonne, M P, Carstensen, B, Beck-Nielsen, H & Vaag, A 2009, ' Increased risk of type 2 diabetes in elderly twins ', Diabetes, vol. 58, no. 6, pp. 1350-5 . https://doi.org/10.2337/db08-1714
Poulsen, P, Grunnet, L G, Pilgaard, K, Storgaard, H, Alibegovic, A, Sonne, M P, Carstensen, B, Beck-Nielsen, H & Vaag, A 2009, ' Increased risk of Type 2 diabetes in Elderly Twins ', Diabetes, vol. 58, no. 6, pp. 1350-1355 . https://doi.org/10.2337/db08-1714

OBJECTIVE Genetic susceptibility, low birth weight (LBW), and aging are key etiological factors in the development of type 2 diabetes. LBW is common among twins. It is unknown whether twin status per se is associated with risk of type 2 diabetes, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20aae0f19e6594971f7d0b85a6bf8f65
https://doi.org/10.2337/db08-1714