Výsledky vyhledávání - "Kasper M A Rouschop"

Akademický článek

Distinct radiation responses after in vitro mtDNA depletion are potentially related to oxidative stress.

Autor: Marike W van Gisbergen, An M Voets, Rianne Biemans, Roland F Hoffmann, Marie-José Drittij-Reijnders, Guido R M M Haenen, Irene H Heijink, Kasper M A Rouschop, Ludwig J Dubois, Philippe Lambin

Publikováno v: PLoS ONE, Vol 12, Iss 8, p e0182508 (2017)

Several clinically used drugs are mitotoxic causing mitochondrial DNA (mtDNA) variations, and thereby influence cancer treatment response. We hypothesized that radiation responsiveness will be enhanced in cellular models with decreased mtDNA content,

Externí odkaz: https://doaj.org/article/462e516ed1d64c4bab3f328b4dc83585

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Akademický článek

Cancer EV stimulate endothelial glycolysis to fuel protein synthesis via mTOR and AMPKα activation

Autor: Joël E. J. Beaumont, Lydie M. O. Barbeau, Jinzhe Ju, Kim G. Savelkouls, Freek G. Bouwman, Marijke I. Zonneveld, Annelies Bronckaers, Kim R. Kampen, Tom G. H. Keulers, Kasper M. A. Rouschop

Publikováno v: Journal of Extracellular Vesicles, Vol 13, Iss 7, Pp n/a-n/a (2024)

Abstract Hypoxia is a common feature of solid tumours and activates adaptation mechanisms in cancer cells that induce therapy resistance and has profound effects on cellular metabolism. As such, hypoxia is an important contributor to cancer progressi

Externí odkaz: https://doaj.org/article/ec4b00231fe04dc18ed39d6c447f3218

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Akademický článek

Hypoxia induced impairment of NK cell cytotoxicity against multiple myeloma can be overcome by IL-2 activation of the NK cells.

Autor: Subhashis Sarkar, Wilfred T V Germeraad, Kasper M A Rouschop, Elisabeth M P Steeghs, Michel van Gelder, Gerard M J Bos, Lotte Wieten

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e64835 (2013)

BACKGROUND: Multiple Myeloma (MM) is an incurable plasma cell malignancy residing within the bone marrow (BM). We aim to develop allogeneic Natural Killer (NK) cell immunotherapy for MM. As the BM contains hypoxic regions and the tumor environment ca

Externí odkaz: https://doaj.org/article/23c9693466bd40a2bb31b7457ccd8acc

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Akademický článek

Physiological Oxygen Levels Differentially Regulate Adipokine Production in Abdominal and Femoral Adipocytes from Individuals with Obesity Versus Normal Weight

Autor: Ioannis G. Lempesis, Nicole Hoebers, Yvonne Essers, Johan W. E. Jocken, Kasper M. A. Rouschop, Ellen E. Blaak, Konstantinos N. Manolopoulos, Gijs H. Goossens

Publikováno v: Cells, Vol 11, Iss 22, p 3532 (2022)

Adipose tissue (AT) inflammation may increase obesity-related cardiometabolic complications. Altered AT oxygen partial pressure (pO2) may impact the adipocyte inflammatory phenotype. Here, we investigated the effects of physiological pO2 levels on th

Externí odkaz: https://doaj.org/article/f6a7f812a4dd4cf4a75938c89df7d5fc

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The Immunomodulatory Role of Hypoxic Tumor-Derived Extracellular Vesicles

Autor: Joel E. J. Beaumont, Nicky A. Beelen, Lotte Wieten, Kasper M. A. Rouschop

Publikováno v: Cancers. 14(16)

Tumor-associated immune cells frequently display tumor-supportive phenotypes. These phenotypes, induced by the tumor microenvironment (TME), are described for both the adaptive and the innate arms of the immune system. Furthermore, they occur at all

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0780c1a2c81a53d01d862b0cbe6a3bc2
https://pubmed.ncbi.nlm.nih.gov/36010994

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Identification of Potential Prognostic and Predictive Immunological Biomarkers in Patients with Stage I and Stage III Non-Small Cell Lung Cancer (NSCLC): A Prospective Exploratory Study

Autor: Rianne D. W. Vaes, Kobe Reynders, Jenny Sprooten, Kathleen T. Nevola, Kasper M. A. Rouschop, Marc Vooijs, Abhishek D. Garg, Maarten Lambrecht, Lizza E. L. Hendriks, Marijana Rucevic, Dirk De Ruysscher

Publikováno v: Cancers; Volume 13; Issue 24; Pages: 6259
Cancers, Vol 13, Iss 6259, p 6259 (2021)
Cancers
Cancers, 13(24):6259. Multidisciplinary Digital Publishing Institute (MDPI)

Simple Summary Over the last 5 years, immune checkpoint inhibitors (ICIs) are increasingly used in the treatment of non-small cell lung cancer (NSCLC) as either monotherapy or in combination with chemo- and/or radiotherapy. However, despite these adv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c90bf9362337820852ea96a8fd14c3e4

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Endogenous tissue-type plasminogen activator is protective during ascending urinary tract infection

Autor: Gerry T. M. Wagenaar, Joris J. T. H. Roelofs, Jan J. Weening, Tom van der Poll, Nike Claessen, Sandrine Florquin, Kasper M. A. Rouschop, Gwendoline J. D. Teske

Publikováno v: Nephrology, dialysis, transplantation, 24(3), 801-808. Oxford University Press

Background Acute pyelonephritis is one of the most common bacterial infections. Tissue-type plasminogen activator (tPA) is a potent fibrinolytic agent, but can play a role in inflammatory processes as well. Methods We induced pyelonephritis in tPA(-/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d47b264d4659f0349ce3e3df78b992b
https://pure.amc.nl/en/publications/endogenous-tissuetype-plasminogen-activator-is-protective-during-ascending-urinary-tract-infection(f037b57a-9938-4e89-af77-69d8aeb42c13).html

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Renal expression of CD44 correlates with acute renal allograft rejection

Autor: I.J.M. ten Berge, Joris J. T. H. Roelofs, S. Florquin, Jan J. Weening, Ajda T. Rowshani, M. Sylva, Kasper M. A. Rouschop

Publikováno v: Kidney international, 70(6), 1127-1134. Nature Publishing Group

As CD44 is involved in the activation, proliferation, adhesion, and extravasation of lymphocytes, we hypothesized that CD44 could be involved in the pathogenesis of acute renal allograft rejection. Renal biopsies and plasma were collected from patien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76df112afb7a21a8ee71881118b3cd16
https://pubmed.ncbi.nlm.nih.gov/16871244

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The urokinase plasminogen activator receptor is crucially involved in host defense during acute pyelonephritis

Autor: Kasper M. A. Rouschop, Sandrine Florquin, Gwendolin Teske, Nike Claessen, Joris J. T. H. Roelofs, T. van der Poll, Jan J. Weening

Publikováno v: Kidney international, 70(11), 1942-1947. Nature Publishing Group

The urokinase plasminogen activator receptor (uPAR) is expressed at the cell surface of inflammatory cells and plays an important role in neutrophil migration. To investigate the in vivo role of uPAR during urinary tract infection, acute pyelonephrit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b475de6af0779b9ca2a5bd1eb0193ce8
https://pure.amc.nl/en/publications/the-urokinase-plasminogen-activator-receptor-is-crucially-involved-in-host-defense-during-acute-pyelonephritis(c9be329e-01a1-46f5-b962-2bdcc901519e).html

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Reciprocal functions of hepatocyte growth factor and transforming growth factor-beta1 in the progression of renal diseases: a role for CD44?

Autor: Sandrine Florquin, Kasper M. A. Rouschop

Publikováno v: Kidney international, 64(Suppl. 86), S15-S20. Nature Publishing Group

Reciprocal functions of hepatocyte growth factor and transforming growth factor-β1 in the progression of renal diseases: A role for CD44? Progressive renal fibrosis occurs via common pathophysiologic mechanisms, regardless of the primary underlying

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cfad89ff11fe8b82f0d6fd20946da71
https://pubmed.ncbi.nlm.nih.gov/12969122

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