Výsledky vyhledávání - "Kasper L. Jønsson"

Akademický článek

T‐cell derived extracellular vesicles prime macrophages for improved STING based cancer immunotherapy

Autor: Aida S. Hansen, Lea S. Jensen, Kristine R. Gammelgaard, Kristoffer G. Ryttersgaard, Christian Krapp, Jesper Just, Kasper L. Jønsson, Pia B. Jensen, Thomas Boesen, Mogens Johannsen, Anders Etzerodt, Bent W. Deleuran, Martin R. Jakobsen

Publikováno v: Journal of Extracellular Vesicles, Vol 12, Iss 8, Pp n/a-n/a (2023)

Abstract A key phenomenon in cancer is the establishment of a highly immunosuppressive tumour microenvironment (TME). Despite advances in immunotherapy, where the purpose is to induce tumour recognition and hence hereof tumour eradication, the majori

Externí odkaz: https://doaj.org/article/243433d9b85349ca81ff3bd193a23e6f

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cAIMPadministration in humanized mice induces a chimerization‐level‐dependentSTINGresponse

Autor: Martin R. Jakobsen, Martin K. Thomsen, Lars Østergaard, Rikke Olesen, Katharina Mack, Christian Krapp, Jesper F Højen, Martin Tolstrup, Frederik Dagnæs-Hansen, Paul W. Denton, Anna H. F. Andersen, Kasper L Jønsson

Publikováno v: Andersen, A H F, Olesen, R, Jønsson, K L, Højen, J F, Krapp, C, Mack, K, Thomsen, M K, Østergaard, L, Tolstrup, M, Dagnæs-Hansen, F, Jakobsen, M R & Denton, P W 2019, ' cAIMP administration in humanized mice induces a chimerization-level-dependent STING response ', Immunology, vol. 157, no. 2, pp. 163-172 . https://doi.org/10.1111/imm.13061
Andersen, A H F, Olesen, R, Jønsson, K L, Højen, J F, Krapp, C, Mack, K, Thomsen, M K, Østergaard, L, Tolstrup, M, Dagnaes-Hansen, F, Jacobsen, M R & Denton, P W 2019, ' cAIMP administration in humanized mice induces a chimerization-level-dependent STING response ' Immunology . https://doi.org/10.1111/imm.13061
Immunology

It is well conceived that the STING signalling pathway is critical for generating a robust innate immune response to pathogens. Human and mouse STING signaling pathways are not identical, however. For example, mice lack IFI16 which has been proven im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a1f8f27964c177fba22bbf3f7aa9c1e
https://doi.org/10.1111/imm.13061

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cGAS is activated by DNA in a length‐dependent manner

Autor: Gerardo A Boni, Mogens Johannsen, Søren R. Paludan, Kasper L Jønsson, Maria H Christensen, Andreas Holleufer, Lambert K. Sørensen, Martin R. Jakobsen, Stefanie Luecke, Rune Hartmann

Publikováno v: Luecke, S, Holleufer, A, Christensen, M H, Jønsson, K L, Boni, G A, Sørensen, L K, Johannsen, M, Jakobsen, M R, Hartmann, R & Paludan, S R 2017, ' cGAS is activated by DNA in a length-dependent manner ', E M B O Reports, vol. 18, no. 10, pp. 1707–1715 . https://doi.org/10.15252/embr.201744017

Cytosolic DNA stimulates innate immune responses, including type I interferons (IFN), which have antiviral and immunomodulatory activities. Cyclic GMP-AMP synthase (cGAS) recognizes cytoplasmic DNA and signals via STING to induce IFN production. Desp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a3238a116ede32dc6a76f7d4c39ae4e
https://doi.org/10.15252/embr.201744017

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Cellular Requirements for Sensing and Elimination of Incoming HSV-1 DNA and Capsids

Autor: Chiranjeevi Bodda, Søren B. Jensen, Bao-Cun Zhang, Søren R. Paludan, Iver Nordentoft, Kasper L Jønsson, Stefanie Luecke, Chenglong Sun, Yujia Cai, Jacob Malte Jensen, Martin R. Jakobsen

Publikováno v: Sun, C, Luecke, S, Bodda, C, Jønsson, K L, Cai, Y, Zhang, B C, Jensen, S B, Nordentoft, I, Jensen, J M, Jakobsen, M R & Paludan, S R 2019, ' Cellular Requirements for Sensing and Elimination of Incoming HSV-1 DNA and Capsids ', Journal of Interferon and Cytokine Research, vol. 39, no. 4, pp. 191-204 . https://doi.org/10.1089/jir.2018.0141

Incoming viruses challenge the cell with diverse foreign molecules, which need to be sensed quickly to initiate immune responses and to remove the viral components. In this study, we investigate the cellular requirements for sensing and degradation o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02e60bb670fb81d0b2940c5ce8550fef
https://pure.au.dk/portal/da/publications/cellular-requirements-for-sensing-and-elimination-of-incoming-hsv1-dna-and-capsids(29e121b6-2fba-443e-8ddd-35b46d17fb55).html

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IFI16 Targets the Transcription Factor Sp1 to Suppress HIV-1 Transcription and Latency Reactivation

Autor: Christian Krapp, Ben Berkhout, Matteo Bosso, Martin R. Jakobsen, Sabine Wittmann, Thomas Gramberg, Kasper L Jønsson, Daniel Sauter, Christina M. Stürzel, Dominik Hotter, Elisabeth Littwitz-Salomon, Yue Zheng, Alina Russ, Ulf Dittmer, Frank Kirchhoff, Vicente Planelles, Beatrice H. Hahn, Atze T. Das, Laura J. Martins

Publikováno v: Cell Host Microbe
Cell host & microbe, 25(6), 858-872.e13. Cell Press
Hotter, D, Bosso, M, Jønsson, K L, Krapp, C, Stürzel, C M, Das, A, Littwitz-Salomon, E, Berkhout, B, Russ, A, Wittmann, S, Gramberg, T, Zheng, Y, Martins, L J, Planelles, V, Jakobsen, M R, Hahn, B H, Dittmer, U, Sauter, D & Kirchhoff, F 2019, ' IFI16 Targets the Transcription Factor Sp1 to Suppress HIV-1 Transcription and Latency Reactivation ', Cell Host & Microbe, vol. 25, no. 6, pp. 858-872.e13 . https://doi.org/10.1016/j.chom.2019.05.002

The interferon γ-inducible protein 16 (IFI16) is known as immune sensor of retroviral DNA intermediates. We show that IFI16 restricts HIV-1 independently of immune sensing by binding and inhibiting the host transcription factor Sp1 that drives viral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b93eaf6091748b26f0f5b957ff835c60
https://pubmed.ncbi.nlm.nih.gov/31175045

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Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage

Autor: Christina Paulus, Jessica F. Almine, Gillian Dunphy, Andrew G. Bowie, Michael Nevels, Sinead M. Flannery, Leonie Unterholzner, Martin R. Jakobsen, Dympna J. Connolly, Kasper L Jønsson

Publikováno v: Dunphy, G, Flannery, S M, Almine, J F, Connolly, D J, Paulus, C, Jønsson, K L, Jakobsen, M R, Nevels, M M, Bowie, A G & Unterholzner, L 2018, ' Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage ', Molecular Cell, vol. 71, no. 5, pp. 745-760.e5 . https://doi.org/10.1016/j.molcel.2018.07.034
Molecular Cell

Summary DNA damage can be sensed as a danger-associated molecular pattern by the innate immune system. Here we find that keratinocytes and other human cells mount an innate immune response within hours of etoposide-induced DNA damage, which involves

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6795a2e235e6f9e4dee4197c761c1f21
https://pure.au.dk/portal/da/publications/noncanonical-activation-of-the-dna-sensing-adaptor-sting-by-atm-and-ifi16-mediates-nfb-signaling-after-nuclear-dna-damage(d7ae71a7-c1f9-4b6f-aff7-5ad67fff82d9).html

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STING dependent sensing - Does HIV actually care?

Autor: Kasper L Jønsson, Martin R. Jakobsen, Christian Krapp

Publikováno v: Krapp, C, Jønsson, K & Jakobsen, M R 2018, ' STING dependent sensing-Does HIV actually care? ', Cytokine & Growth Factor Reviews, pp. 68-76 . https://doi.org/10.1016/j.cytogfr.2018.03.002

Sensing of DNA is essential for the innate immune system to detect threats, like viruses, intracellular bacteria or cellular DNA damage. At the centre of this conserved mammalian mechanism stands the adaptor protein STING. STING is highly regulated a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8237754f610b9e0e69c1a0090e8d6c3
https://pure.au.dk/portal/da/publications/sting-dependent-sensing--does-hiv-actually-care(b5252981-4101-41c7-bc27-a520ea1ef868).html

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CD11c-targeted delivery of DNA to dendritic cells leads to cGAS- and STING-dependent maturation

Autor: Martin R. Jakobsen, Marlene Fyrstenberg Laursen, Kasper L Jønsson, Emil Kofod-Olsen, Laura L. T. Degn, Ralf Agger, Esben Christensen

Publikováno v: Laursen, M F, Christensen, E, Degn, L L T, Jønsson, K, Jakobsen, M R, Agger, R & Kofod-Olsen, E 2018, ' CD11c-targeted delivery of DNA to dendritic cells leads to cGAS-and STING-dependent maturation ', Journal of Immunotherapy, vol. 41, no. 1, pp. 9-18 . https://doi.org/10.1097/CJI.0000000000000195
Laursen, M F, Christensen, E, Degn, L L T, Jønsson, K, Jakobsen, M R, Agger, R & Kofod-Olsen, E 2018, ' CD11c-targeted Delivery of DNA to Dendritic Cells Leads to cGAS-and STING-dependent Maturation ', Journal of Immunotherapy, vol. 41, no. 1, pp. 9-18 . https://doi.org/10.1097/CJI.0000000000000195

Immunotherapeutic activation of tumor-specific T cells has proven to be an interesting approach in anticancer treatment. Particularly, anti-CTLA-4 and anti-PD-1/PD-L1 treatment looks promising, and conceivably, even better clinical results might be o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d37f02769d1f22d36d14f7ee681e1770
https://vbn.aau.dk/da/publications/ddd85507-dcfc-45ee-88b7-647758443f7e

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IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Jønsson, K L, Laustsen, A, Krapp, C, Skipper, K A, Thavachelvam, K, Hotter, D, Egedal, J H, Kjolby, M, Mohammadi, P, Prabakaran, T, Sørensen, L K, Sun, C, Jensen, S B, Holm, C K, Lebbink, R J, Johannsen, M, Nyegaard, M, Mikkelsen, J G, Kirchhoff, F, Paludan, S R & Jakobsen, M R 2017, ' IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP ', Nature Communications, vol. 8, 14391 . https://doi.org/10.1038/ncomms14391
Nature Communications
Nature Communications [E], 8. Nature Publishing Group

Innate immune activation by macrophages is an essential part of host defence against infection. Cytosolic recognition of microbial DNA in macrophages leads to induction of interferons and cytokines through activation of cyclic GMP-AMP synthase (cGAS)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06ce14ccd79c5928ca15f6b72d02c316
https://dspace.library.uu.nl/handle/1874/350466

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Histone Deacetylase Inhibitor Romidepsin Inhibits De Novo HIV-1 Infections

Autor: Martin Tolstrup, Morten Andersen, Paul W. Denton, Ole Schmeltz Søgaard, Martin R. Jakobsen, Thomas A Rasmussen, Kathrine Kjær, Anders Laustsen, Lars Østergaard, Kasper L Jønsson, Johan Vad-Nielsen

Publikováno v: Jønsson, K L, Tolstrup, M, Vad-Nielsen, J, Kjær, K, Laustsen, A, Andersen, M N, Rasmussen, T A, Søgaard, O S, Østergaard, L J, Denton, P W & Jakobsen, M R 2015, ' Histone Deacetylase Inhibitor Romidepsin Inhibits de novo HIV-1 Infections ', Antimicrobial Agents and Chemotherapy, vol. 59, no. 7, pp. 3984-3994 . https://doi.org/10.1128/AAC.00574-15

Adjunct therapy with the histone deacetylase inhibitor (HDACi) romidepsin increases plasma viremia in HIV patients on combination antiretroviral therapy (cART). However, a potential concern is that reversing HIV latency with an HDACi may reactivate t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70aeac710c9630c33a49ea661a78ee3c
https://europepmc.org/articles/PMC4468708/

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