Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Kasper Kjaer-Sorensen"'
Autor:
Mette Harboe, Kasper Kjaer-Sorensen, Ernst-Martin Füchtbauer, Robert A. Fenton, Jesper Skovhus Thomsen, Annemarie Brüel, Claus Oxvig
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Insulin-like growth factor (IGF) signaling is required for proper growth and skeletal development in vertebrates. Consequently, its dysregulation may lead to abnormalities of growth or skeletal structures. IGF is involved in the regulation o
Externí odkaz:
https://doaj.org/article/45aba06494fa43148864fd55ae942a88
Autor:
Pernille Bogetofte Thomasen, Alena Salasova, Kasper Kjaer-Sorensen, Lucie Woloszczuková, Josef Lavický, Hande Login, Jeppe Tranberg-Jensen, Sergio Almeida, Sander Beel, Michaela Kavková, Per Qvist, Mads Kjolby, Peter Lund Ovesen, Stella Nolte, Benedicte Vestergaard, Andreea-Cornelia Udrea, Lene Niemann Nejsum, Moses V. Chao, Philip Van Damme, Jan Krivanek, Jeremy Dasen, Claus Oxvig, Anders Nykjaer
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113333- (2023)
Summary: Motor neuron (MN) development and nerve regeneration requires orchestrated action of a vast number of molecules. Here, we identify SorCS2 as a progranulin (PGRN) receptor that is required for MN diversification and axon outgrowth in zebrafis
Externí odkaz:
https://doaj.org/article/70f099b4a581474b967f6fa6ea663779
Autor:
Chengdong Liu, Shuang Li, Pernille Rimmer Noer, Kasper Kjaer-Sorensen, Anna Karina Juhl, Allison Goldstein, Caihuan Ke, Claus Oxvig, Cunming Duan
Publikováno v:
eLife, Vol 9 (2020)
Human patients carrying PAPP‐A2 inactivating mutations have low bone mineral density. The underlying mechanisms for this reduced calcification are poorly understood. Using a zebrafish model, we report that Papp-aa regulates bone calcification by pr
Externí odkaz:
https://doaj.org/article/0bcae0e54105480c85a3d4cb42e66262
Loss-of-activity-mutation in the cardiac chloride-bicarbonate exchanger AE3 causes short QT syndrome
Autor:
Kasper Thorsen, Vibeke S. Dam, Kasper Kjaer-Sorensen, Lisbeth N. Pedersen, V. Arvydas Skeberdis, Jonas Jurevičius, Rimantas Treinys, Ida M. B. S. Petersen, Morten S. Nielsen, Claus Oxvig, J. Preben Morth, Vladimir V. Matchkov, Christian Aalkjær, Henning Bundgaard, Henrik K. Jensen
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Mutations in potassium and calcium channel genes have been associated with cardiac arrhythmias. Here, Jensen et al. show that an anion transporter chloride-bicarbonate exchanger AE3 is also responsible for the genetically-induced mechanism of cardiac
Externí odkaz:
https://doaj.org/article/97e6cbf2131e4127b04d04f0aede118d
Autor:
Julie Torvund-Jensen, Jes Steengaard, Liselotte B. Askebjerg, Kasper Kjaer-Sorensen, Lisbeth S. Laursen
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
Formation of functional myelin sheaths within the central nervous system depends on expression of myelin basic protein (MBP). Following process extension and wrapping around axonal segments, this highly basic protein is required for compaction of the
Externí odkaz:
https://doaj.org/article/a37633e7a5be46a2aefb485f17b5640b
Autor:
Carina Henriksen, Kasper Kjaer-Sorensen, Anja Pernille Einholm, Lone Bruhn Madsen, Jamal Momeni, Christian Bendixen, Claus Oxvig, Bente Vilsen, Knud Larsen
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79127 (2013)
Na⁺/K⁺-ATPase maintains electrochemical gradients of Na⁺ and K⁺ essential for a variety of cellular functions including neuronal activity. The α-subunit of the Na⁺/K⁺-ATPase exists in four different isoforms (α1-α4) encoded by differen
Externí odkaz:
https://doaj.org/article/3faffdd99f9d4a7d84a871f5e5fe367e
Autor:
Cagla Cömert, Kasper Kjær-Sørensen, Jakob Hansen, Jasper Carlsen, Jesper Just, Brandon F. Meaney, Elsebet Østergaard, Yonglun Luo, Claus Oxvig, Lisbeth Schmidt-Laursen, Johan Palmfeldt, Paula Fernandez-Guerra, Peter Bross
Publikováno v:
Molecular Metabolism, Vol 88, Iss , Pp 102009- (2024)
Objective: Mitochondrial proteostasis is critical for cellular function. The molecular chaperone HSP60 is essential for cell function and dysregulation of HSP60 expression has been implicated in cancer and diabetes. The few reported patients carrying
Externí odkaz:
https://doaj.org/article/3ec01ba56131408a8f12c0a8c06887b3
Autor:
Hossein Mohammad-Beigi, Duncan S. Sutherland, Thomas Boesen, Yuya Hayashi, Pia Jensen, Carsten Scavenius, Claus Oxvig, Jan J. Enghild, Kasper Kjaer-Sorensen
Publikováno v:
Mohammad-Beigi, H, Scavenius, C, Jensen, P B, Kjaer-Sorensen, K, Oxvig, C, Boesen, T, Enghild, J J, Sutherland, D S & Hayashi, Y 2020, ' Tracing the In Vivo Fate of Nanoparticles with a "Non-Self" Biological Identity ', ACS Nano, vol. 14, no. 8, pp. 10666-10679 . https://doi.org/10.1101/2020.03.27.012146, https://doi.org/10.1021/acsnano.0c05178
Nanoparticles can acquire a biomolecular corona with a species-specific biological identity. However, “non-self” incompatibility of recipient biological systems is often not considered, for example, when rodents are used as a model organism for p
Autor:
Claus Oxvig, Ulrike G. Larsen, Jan J. Enghild, Ebbe Toftgaard Poulsen, Kasper Kjaer-Sorensen, Cecilie Linneberg Matthiesen, Annemarie Brüel, Steen V. Petersen, Astrid S. Torslev, Jesper Skovhus Thomsen, Lili Hu
Publikováno v:
Matthiesen, C L, Hu, L, Torslev, A S, Poulsen, E T, Larsen, U G, Kjaer-Sorensen, K, Thomsen, J S, Brüel, A, Enghild, J J, Oxvig, C & Petersen, S V 2021, ' Superoxide dismutase 3 is expressed in bone tissue and required for normal bone homeostasis and mineralization ', Free Radical Biology and Medicine, vol. 164, pp. 399-409 . https://doi.org/10.1016/j.freeradbiomed.2021.01.027
Superoxide dismutase 3 (SOD3) is an extracellular protein with the capacity to convert superoxide into hydrogen peroxide, an important secondary messenger in redox regulation. To investigate the utility of zebrafish in functional studies of SOD3 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::136ff5e56d25f2e668189fc1df9e1427
https://pure.au.dk/portal/da/publications/superoxide-dismutase-3-is-expressed-in-bone-tissue-and-required-for-normal-bone-homeostasis-and-mineralization(67f93f18-385d-4678-9979-bf863f5237a0).html
https://pure.au.dk/portal/da/publications/superoxide-dismutase-3-is-expressed-in-bone-tissue-and-required-for-normal-bone-homeostasis-and-mineralization(67f93f18-385d-4678-9979-bf863f5237a0).html
Autor:
Rasmus Hejlesen, Freja Burkarl Scheffler, Clara Garfiel Byrge, Kasper Kjær-Sørensen, Claus Oxvig, Angela Fago, Hans Malte
Publikováno v:
Biology Open, Vol 13, Iss 6 (2024)
Externí odkaz:
https://doaj.org/article/387e6ead3e1946319b7ce5f62ce86a91