Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Kasper Harpsøe"'
Autor:
Chihiro Nakamoto, Yuhei Goto, Yoko Tomizawa, Yuko Fukata, Masaki Fukata, Kasper Harpsøe, David E. Gloriam, Kazuhiro Aoki, Tomonori Takeuchi
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-14 (2021)
Abstract Dopamine (DA) and norepinephrine (NE) are pivotal neuromodulators that regulate a broad range of brain functions, often in concert. Despite their physiological importance, untangling the relationship between DA and NE in the fine control of
Externí odkaz:
https://doaj.org/article/f81a0da714344452943514f5d04d1252
Autor:
Jimmy Caroli, Alibek Mamyrbekov, Kasper Harpsøe, Sahar Gardizi, Linda Dörries, Eshan Ghosh, Alexander S. Hauser, Albert J. Kooistra, David E. Gloriam
Publikováno v:
Nature Chemical Biology. 19:531-535
Autor:
Emil Marcher-Rørsted, Jitka Nykodemová, Kasper Harpsøe, Anders A. Jensen, Jesper L. Kristensen
Publikováno v:
ACS Medicinal Chemistry Letters. 14:319-325
Autor:
Christian R. O. Bartling, Flora Alexopoulou, Sarah Kuschert, Yanni K.-Y. Chin, Xinying Jia, Vita Sereikaite, Dennis Özcelik, Thomas M. Jensen, Palash Jain, Mads M. Nygaard, Kasper Harpsøe, David E. Gloriam, Mehdi Mobli, Kristian Strømgaard
Publikováno v:
Journal of Medicinal Chemistry. 66:3045-3057
Autor:
Yali Zhou, Henrik Daver, Boris Trapkov, Lijie Wu, Meng Wu, Kasper Harpsøe, Patrick R. Gentry, Kaiwen Liu, Marina Larionova, Junlin Liu, Na Chen, Hans Bräuner-Osborne, David E. Gloriam, Tian Hua, Zhi-Jie Liu
Publikováno v:
Cell Research
Zhou, Y, Daver, H, Trapkov, B, Wu, L, Wu, M, Harpsøe, K, Gentry, P R, Liu, K, Larionova, M, Liu, J, Chen, N, Bräuner-Osborne, H, Gloriam, D E, Hua, T & Liu, Z J 2022, ' Molecular insights into ligand recognition and G protein coupling of the neuromodulatory orphan receptor GPR139 ', Cell Research, vol. 32, no. 2, pp. 210-213 . https://doi.org/10.1038/s41422-021-00591-w
Zhou, Y, Daver, H, Trapkov, B, Wu, L, Wu, M, Harpsøe, K, Gentry, P R, Liu, K, Larionova, M, Liu, J, Chen, N, Bräuner-Osborne, H, Gloriam, D E, Hua, T & Liu, Z J 2022, ' Molecular insights into ligand recognition and G protein coupling of the neuromodulatory orphan receptor GPR139 ', Cell Research, vol. 32, no. 2, pp. 210-213 . https://doi.org/10.1038/s41422-021-00591-w
The G protein-coupled receptor GPR139 is involved in neuromodulation, and one of its agonists is in clinical trials for the treatment of cognitive impairment and negative symptoms of schizophrenia. While GPR139 is a understudied ‘orphan’ receptor
Autor:
Jimmy Caroli, Alibek Mamyrbekov, Kasper Harpsøe, Sahar Gardizi, Linda Dörries, Eshan Ghosh, Alexander Hauser, Albert Kooistra, David Gloriam
Biased signaling is a paradigm in signal transduction whereby hormones, probes, or drugs bind the same receptor but engage different intracellular signaling pathways leading to distinct functional outcomes. Whereas there is a wealth of knowledge of b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63a11ac73dbd339303f540d89d777140
https://doi.org/10.21203/rs.3.rs-2155951/v1
https://doi.org/10.21203/rs.3.rs-2155951/v1
Autor:
Christian B M, Poulie, Eline, Pottie, Icaro A, Simon, Kasper, Harpsøe, Laura, D'Andrea, Igor V, Komarov, David E, Gloriam, Anders A, Jensen, Christophe P, Stove, Jesper L, Kristensen
Publikováno v:
Journal of medicinal chemistry. 65(18)
The serotonin 2A receptor (5-HT
Autor:
Sijie Huang, Peiyu Xu, Dan-Dan Shen, Icaro A. Simon, Chunyou Mao, Yangxia Tan, Huibing Zhang, Kasper Harpsøe, Huadong Li, Yumu Zhang, Chongzhao You, Xuekui Yu, Yi Jiang, Yan Zhang, David E. Gloriam, H. Eric Xu
Publikováno v:
Huang, S, Xu, P, Shen, D D, Simon, I A, Mao, C, Tan, Y, Zhang, H, Harpsøe, K, Li, H, Zhang, Y, You, C, Yu, X, Jiang, Y, Zhang, Y, Gloriam, D E & Xu, H E 2022, ' GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors ', Molecular cell, vol. 82, no. 14, pp. 2681-2695.e6 . https://doi.org/10.1016/j.molcel.2022.05.031
Molecular cell, 82(14), 2681-2695.e6. Cell Press
Molecular cell, 82(14), 2681-2695.e6. Cell Press
Serotonin (or 5-hydroxytryptamine, 5-HT) is an important neurotransmitter that activates 12 different G protein-coupled receptors (GPCRs) through selective coupling of Gs, Gi, or Gq proteins. The structural basis for G protein subtype selectivity by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54c14e6f3505ee05c519a1463efa9c29
https://hdl.handle.net/1871.1/713d857a-269d-42a6-a385-466fed3a7d58
https://hdl.handle.net/1871.1/713d857a-269d-42a6-a385-466fed3a7d58
Autor:
David E. Gloriam, Rebekka Löffler, Frederik Rostrup, Petrine Wellendorph, Bente Frølund, Christina Birkedahl Falk-Petersen, Kasper Harpsøe, Stine Buchleithner
Publikováno v:
Molecular Pharmacology. 100:46-56
Delta selective compound 2 (DS2; 4-chloro-N-[2-(2-thienyl)imidazo[1,2-a]pyridin-3-yl]benzamide) is one of the most widely used tools to study selective actions mediated by δ-subunit-containing GABAA receptors. DS2 was discovered over 10 years ago, b
Autor:
H. Eric Xu, Hsin-Yung Yen, Xi Cheng, Huibing Zhang, David E. Gloriam, Carol V. Robinson, Jia Guo, Yi Jiang, Kasper Harpsøe, Karsten Melcher, Sijie Huang, X. Edward Zhou, Hualiang Jiang, Yan Zhang, Ícaro Ariel Simon, Dan-Dan Shen, Peiyu Xu, Chunyou Mao, Bo Svensson
Publikováno v:
Nature
Serotonin, or 5-hydroxytryptamine (5-HT), is an important neurotransmitter1,2 that activates the largest subtype family of G-protein-coupled receptors3. Drugs that target 5-HT1A, 5-HT1D, 5-HT1E and other 5-HT receptors are used to treat numerous diso