Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Kasper C. D. Roet"'
Publikováno v:
Cell Transplantation, Vol 21 (2012)
In this study, we assess the feasibility of bioluminescence imaging to monitor the survival of Schwann cells (SCs) and olfactory ensheathing glia cells (OECs) after implantation in the lesioned spinal cord of adult rats. To this end, purified SCs and
Externí odkaz:
https://doaj.org/article/9a53dcaef2a14b398520c0cca180e1bb
Autor:
Matthew C. Kiernan, Steve Vucic, Toby A. Ferguson, Catherine Cummings, Kasper C D Roet, Merit Cudkowicz, Michael T Hotchkin, Angela Genge, Robert Glanzman
Publikováno v:
Muscle & Nerve. 64:532-537
Diagnostic criteria for amyotrophic lateral sclerosis (ALS) are complex, incorporating multiple levels of certainty from possible through to definite, and are thereby prone to error. Specifically, interrater variability was previously established to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f035c247bfb952f7e26d1dbca7da8d
https://doi.org/10.1002/mus.27392
https://doi.org/10.1002/mus.27392
Autor:
Bruno Boivin, Kasper C. D. Roet, Xuan Huang, Kyle W. Karhohs, Mohammad H. Rohban, Jack Sandoe, Ole Wiskow, Rie Maeda, Alyssa Grantham, Mary K. Dornon, Jenny Shao, Devlin Frost, Dylan Baker, Kevin Eggan, Anne E. Carpenter, Clifford J. Woolf
Publikováno v:
Molecular biology of the cell. 33(6)
Patient stem cell-derived models enable imaging of complex disease phenotypes and the development of scalable drug discovery platforms. Current preclinical methods for assessing cellular activity do not, however, capture the full intricacies of disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddd2c82c6b28e9993138886d74b0702e
https://pubmed.ncbi.nlm.nih.gov/34910584
https://pubmed.ncbi.nlm.nih.gov/34910584
Autor:
Janell L.M. Smith, Mark-Anthony Bray, Thomas Schwarz, Robin J. Kleiman, Ole Wiskow, Kasper C. D. Roet, Kyle W. Karhohs, Wei Wei, Anne E. Carpenter, Kaan Apaydin, Evgeny Shlevkov, Pin-Fang Chen, Himanish Basu, Xuan Huang, Kevin Eggan, Zheng Sun
Publikováno v:
Cell Reports, Vol 28, Iss 12, Pp 3224-3237.e5 (2019)
Cell reports
Cell reports
SUMMARY Dysregulated axonal trafficking of mitochondria is linked to neurodegenerative disorders. We report a high-content screen for small-molecule regulators of the axonal transport of mitochondria. Six compounds enhanced mitochondrial transport in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fc2022923c43703568f9c0c6c7b91c5
http://www.sciencedirect.com/science/article/pii/S2211124719310757
http://www.sciencedirect.com/science/article/pii/S2211124719310757
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109401 (2014)
In their natural habitat, the peripheral nerve, Schwann cells (SCs) form nicely aligned pathways (also known as the bands of Büngner) that guide regenerating axons to their targets. Schwann cells that are implanted in the lesioned spinal cord fail t
Externí odkaz:
https://doaj.org/article/37beb99012664bc8ae5758d4287c1528
Autor:
Rie Maeda, Anne E. Carpenter, Kyle W. Karhohs, Boivin B, Baker D, Alyssa Grantham, Mary K. Dornon, Mohammad Hossein Rohban, Ole Wiskow, Kevin Eggan, Kasper C. D. Roet, Devlin Frost, Shao J, Xin-Yun Huang, Jackson Sandoe, Clifford J. Woolf
Patient stem cell-derived models enable imaging of complex disease phenotypes and the development of scalable drug discovery platforms. Current preclinical methods for assessing cellular activity do not, however, capture the full intricacies of disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b17cadb7dd5f9567a3b7179ceacf874
https://doi.org/10.1101/2021.06.22.449195
https://doi.org/10.1101/2021.06.22.449195
Autor:
Ruben Eggers, Fred de Winter, Stefan A Hoyng, Kasper C D Roet, Erich M Ehlert, Martijn J A Malessy, Joost Verhaagen, Martijn R Tannemaat
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71076 (2013)
Although the peripheral nerve is capable of regeneration, only a small minority of patients regain normal function after surgical reconstruction of a major peripheral nerve lesion, resulting in a severe and lasting negative impact on the quality of l
Externí odkaz:
https://doaj.org/article/c730a81bf45b4789b745b5224acc8050
Autor:
Ole Wiskow, Clifford J. Woolf, Kasper C. D. Roet, Jackie Klug-McLeod, Devlin Frost, Karen L. Leach, Kevin Eggan, Hongying Yang, Anthony J. Coyle, Allison P. Berg, Amy Brault, Anne B. Jefferson, Liying Zhang, Seungkyu Lee, Mary K. Dornon, Joseph R. Klim, Dongyi Zhao, Fabien Vincent, Rie Maeda, Kuchuan Chen, Xuan Huang, Alyssa Grantham
Publikováno v:
SSRN Electronic Journal.
Drug development is hampered by poor target selection. Phenotypic screens using cells differentiated from patient stem cells offer the possibility to validate known and discover novel disease targets in an unbiased fashion. To identify targets for ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e6f1bb97fd580a9ea16fe798b3ffeb6
https://doi.org/10.2139/ssrn.3596591
https://doi.org/10.2139/ssrn.3596591
Autor:
Kasper C. D. Roet, Joost Verhaagen
Publikováno v:
Experimental Neurology, 261C, 594-609. Academic Press
Roet, K C D & Verhaagen, J 2014, ' Understanding the neural repair-promoting properties of olfactory ensheathing cells ', Experimental Neurology, vol. 261, pp. 594-609 . https://doi.org/10.1016/j.expneurol.2014.05.007
Experimental Neurology, 261, 594-609. Academic Press Inc.
Roet, K C D & Verhaagen, J 2014, ' Understanding the neural repair-promoting properties of olfactory ensheathing cells ', Experimental Neurology, vol. 261, pp. 594-609 . https://doi.org/10.1016/j.expneurol.2014.05.007
Experimental Neurology, 261, 594-609. Academic Press Inc.
Olfactory ensheathing glial cells (OECs) are a specialized type of glia that form a continuously aligned cellular pathway that actively supports unprecedented regeneration of primary olfactory axons from the periphery into the central nervous system.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25577e93220fa854201a046a90441447
https://hdl.handle.net/1871.1/01aa5163-ef30-491f-80ab-6992f54742b6
https://hdl.handle.net/1871.1/01aa5163-ef30-491f-80ab-6992f54742b6
Autor:
Nitish D. Fagoe, Ruben Eggers, August B. Smit, H. M. Eggink, Elske H. P. Franssen, S.-J. J. Zijlstra, R.E. van Kesteren, Kasper C. D. Roet, Anke H. W. Essing, F. M. de Bree, Joost Verhaagen
Publikováno v:
Journal of Neuroscience, 33(27), 11116-11135. Society for Neuroscience
Journal of Neuroscience, 33, 11116-11135. Society for Neuroscience
Roet, K C D, Franssen, E H P, de Bree, F M, Essing, A H, Zijlstra, S J, Fagoe, N D, Eggink, H M, Eggers, R, Smit, A B, van Kesteren, R E & Verhaagen, J 2013, ' A multilevel screening strategy defines a molecular fingerprint of proregenerative olfactory ensheathing cells and identifies SCARB2, a protein that improves regenerative sprouting of injured sensory spinal axons ', The Journal of Neuroscience, vol. 33, no. 27, pp. 11116-11135 . https://doi.org/10.1523/JNEUROSCI.1002-13.2013
The Journal of Neuroscience, 33(27), 11116-11135. Society for Neuroscience
Roet, K C D, Franssen, E H P, de Bree, F M, Essing, A H, Zijlstra, S J, Fagoe, N D, Eggink, H M, Eggers, R, Smit, A B, van Kesteren, R E & Verhaagen, J 2013, ' A multilevel screening strategy defines a molecular fingerprint of proregenerative olfactory ensheathing cells and identifies SCARB2, a protein that improves regenerative sprouting of injured sensory spinal axons ', Journal of Neuroscience, vol. 33, no. 27, pp. 11116-11135 . https://doi.org/10.1523/JNEUROSCI.1002-13.2013
Journal of Neuroscience, 33, 11116-11135. Society for Neuroscience
Roet, K C D, Franssen, E H P, de Bree, F M, Essing, A H, Zijlstra, S J, Fagoe, N D, Eggink, H M, Eggers, R, Smit, A B, van Kesteren, R E & Verhaagen, J 2013, ' A multilevel screening strategy defines a molecular fingerprint of proregenerative olfactory ensheathing cells and identifies SCARB2, a protein that improves regenerative sprouting of injured sensory spinal axons ', The Journal of Neuroscience, vol. 33, no. 27, pp. 11116-11135 . https://doi.org/10.1523/JNEUROSCI.1002-13.2013
The Journal of Neuroscience, 33(27), 11116-11135. Society for Neuroscience
Roet, K C D, Franssen, E H P, de Bree, F M, Essing, A H, Zijlstra, S J, Fagoe, N D, Eggink, H M, Eggers, R, Smit, A B, van Kesteren, R E & Verhaagen, J 2013, ' A multilevel screening strategy defines a molecular fingerprint of proregenerative olfactory ensheathing cells and identifies SCARB2, a protein that improves regenerative sprouting of injured sensory spinal axons ', Journal of Neuroscience, vol. 33, no. 27, pp. 11116-11135 . https://doi.org/10.1523/JNEUROSCI.1002-13.2013
Olfactory ensheathing cells (OECs) have neuro-restorative properties in animal models for spinal cord injury, stroke, and amyotrophic lateral sclerosis. Here we used a multistep screening approach to discover genes specifically contributing to the re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::570f96bbe6c9b048715475373802347c
https://hdl.handle.net/20.500.11755/94f10bbc-b0da-4319-ae6d-12478e27d590
https://hdl.handle.net/20.500.11755/94f10bbc-b0da-4319-ae6d-12478e27d590