Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Kasper Bendix Johnsen"'
Autor:
Annette Burkhart, Kasper Bendix Johnsen, Tina Skjørringe, Asbjørn Haaning Nielsen, Lisa Juul Routhe, Sandra Hertz, Lisbeth Birk Møller, Lars Lykke Thomsen, Torben Moos
Publikováno v:
Nutrients, Vol 16, Iss 19, p 3264 (2024)
Background/Objectives: Iron (Fe) is a co-factor for enzymes of the developing brain necessitating sufficient supply. We investigated the effects of administering ferric derisomaltose/Fe isomaltoside (FDI) subcutaneously to Fe-deficient (ID) pregnant
Externí odkaz:
https://doaj.org/article/1cda8fe63fb84217834ad2855138a162
Autor:
Steinunn Sara Helgudóttir, Kasper Bendix Johnsen, Lisa Greve Routhe, Charlotte Laurfelt Munch Rasmussen, Maj Schneider Thomsen, Torben Moos
Publikováno v:
Cells, Vol 13, Iss 14, p 1181 (2024)
Background: Transferrin receptor 1 (TfR1), glucose transporter 1 (GLUT1), and CD98hc are candidates for targeted therapy at the blood–brain barrier (BBB). Our objective was to challenge the expression of TfR1, GLUT1, and CD98hc in brain capillaries
Externí odkaz:
https://doaj.org/article/ab947a73d6634cf9af1885d14fd180bd
Autor:
Krzysztof Kucharz, Kasper Kristensen, Kasper Bendix Johnsen, Mette Aagaard Lund, Micael Lønstrup, Torben Moos, Thomas Lars Andresen, Martin Johannes Lauritzen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Limited understanding of the interactions between nanoparticle drug carriers and the blood-brain barrier underlies many translational failures in treatments of brain disorders. Here the authors use two-photon microscopy in mice to characterize the re
Externí odkaz:
https://doaj.org/article/3ecb3577f7e2486e85315477978e25ca
Autor:
Maj Schneider Thomsen, Kasper Bendix Johnsen, Krzysztof Kucharz, Martin Lauritzen, Torben Moos
Publikováno v:
Pharmaceutics, Vol 14, Iss 10, p 2237 (2022)
The blood–brain barrier (BBB), built by brain endothelial cells (BECs), is impermeable to biologics. Liposomes and other nanoparticles are good candidates for the delivery of biologics across the BECs, as they can encapsulate numerous molecules of
Externí odkaz:
https://doaj.org/article/032e5a6f16ef45dc9d4dac4f340b4596
Autor:
Esben Christensen, Johann Mar Gudbergsson, Thomas Lars Andresen, Andreas Kjaer, Kasper Bendix Johnsen, Serhii Kostrikov, Torben Moos, Meg Duroux
Publikováno v:
Gudbergsson, J M, Christensen, E, Kostrikov, S, Moos, T, Duroux, M, Kjær, A, Johnsen, K B & Andresen, T L 2020, ' Conventional Treatment of Glioblastoma Reveals Persistent CD44+ Subpopulations ', Molecular Neurobiology, vol. 57, no. 9, pp. 3943-3955 . https://doi.org/10.1007/s12035-020-02004-2
Glioblastoma (GBM) is the most frequent and devastating primary tumor of the central nervous system with a median survival of 12 to 15 months after diagnosis. GBM is highly difficult to treat due to its delicate location, inter- and intra-tumoral het
Publikováno v:
Cancer and Metastasis Reviews. 39:959-968
Cancer treatment remains a challenge due to a high level of intra- and intertumoral heterogeneity and the rapid development of chemoresistance. In the brain, this is further hampered by the blood-brain barrier that reduces passive diffusion of drugs
Autor:
Steinunn Sara Helgudóttir, Kasper Bendix Johnsen, Lisa Juul Routhe, Charlotte L.M. Rasmussen, Azra Karamehmedovic, Maj Schneider Thomsen, Torben Moos
BackgroundThe objectives of the present study were to investigate whether the expression of transferrin receptor 1 (TfR1), glucose transporter 1 (Glut1), or Cluster of Differentiation 98 Heavy Chain (CD98hc) is epigenetically regulated in brain capil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce493df1c2a6de1602fb6d71ad190e26
https://doi.org/10.21203/rs.3.rs-1220062/v1
https://doi.org/10.21203/rs.3.rs-1220062/v1
Autor:
Peter L. Møller, Hans Christian Cederberg Helms, Mette Nyegaard, András Harazin, Paul J. Kempen, Dora V. Lipka, Morten Nielsen, Torben Moos, Andrea E. Tóth, Annette Burkhart, Maj Schneider Thomsen, Kasper Bendix Johnsen, Charlotte Goldeman, Birger Brodin, Thomas Lars Andresen, Adrian Klepe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f15ce7734fa7d2dac1e65742fc1320f
https://doi.org/10.1111/febs.16225/v2/response1
https://doi.org/10.1111/febs.16225/v2/response1
Autor:
Kasper Kristensen, Krzysztof Kucharz, Micael Lønstrup, Kasper Bendix Johnsen, Martin Lauritzen, Mette Aagaard Lund, Torben Moos, Thomas Lars Andresen
Publikováno v:
Kucharz, K, Kristensen, K, Johnsen, K B, Lund, M A, Lønstrup, M, Moos, T, Andresen, T L & Lauritzen, M J 2021, ' Post-capillary venules are the key locus for transcytosis-mediated brain delivery of therapeutic nanoparticles ', Nature Communications, vol. 12, no. 1, 4121 . https://doi.org/10.1038/s41467-021-24323-1
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Effective treatments of neurodegenerative diseases require drugs to be actively transported across the blood-brain barrier (BBB). However, nanoparticle drug carriers explored for this purpose show negligible brain uptake, and the lack of basic unders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d660991e3553c8e852e13e0481e5cbd
https://vbn.aau.dk/ws/files/431085187/s41467_021_24323_1.pdf
https://vbn.aau.dk/ws/files/431085187/s41467_021_24323_1.pdf
Autor:
Andreas Kjaer, Petra Hamerlik, Casper Hempel, Johann Mar Gudbergsson, Thomas Hartig Braunstein, Thomas Lars Andresen, Frederikke P. Fliedner, Anders Elias Hansen, Elisabeth Anne Adanma Obara, Kasper Bendix Johnsen, Serhii Kostrikov
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Kostrikov, S, Johnsen, K B, Braunstein, T H, Gudbergsson, J M, Fliedner, F P, Obara, E A A, Hamerlik, P, Hansen, A E, Kjaer, A, Hempel, C & Andresen, T L 2021, ' Optical tissue clearing and machine learning can precisely characterize extravasation and blood vessel architecture in brain tumors ', Communications Biology, vol. 4, no. 1, 815 . https://doi.org/10.1038/s42003-021-02275-y
Communications Biology
Kostrikov, S, Johnsen, K B, Braunstein, T H, Gudbergsson, J M, Fliedner, F P, Obara, E A A, Hamerlik, P, Hansen, A E, Kjaer, A, Hempel, C & Andresen, T L 2021, ' Optical tissue clearing and machine learning can precisely characterize extravasation and blood vessel architecture in brain tumors ', Communications Biology, vol. 4, no. 1, 815 . https://doi.org/10.1038/s42003-021-02275-y
Communications Biology
Precise methods for quantifying drug accumulation in brain tissue are currently very limited, challenging the development of new therapeutics for brain disorders. Transcardial perfusion is instrumental for removing the intravascular fraction of an in