Zobrazeno 1 - 10 of 90 pro vyhledávání: '"Kasper B, Hansen"'
1
Akademický článek
Discovery of (R)-2-amino-3-triazolpropanoic acid derivatives as NMDA receptor glycine site agonists with GluN2 subunit-specific activity
Autor: Fabao Zhao, Georgios Mazis, Feng Yi, James S. Lotti, Michael S. Layeux, Eric P. Schultz, Lennart Bunch, Kasper B. Hansen, Rasmus P. Clausen
Publikováno v: Frontiers in Chemistry, Vol 10 (2022)
N-Methyl-d-aspartate (NMDA) receptors play critical roles in central nervous system function and are involved in variety of brain disorders. We previously developed a series of (R)-3-(5-furanyl)carboxamido-2-aminopropanoic acid glycine site agonists
Externí odkaz: https://doaj.org/article/a249e2aa3e9549c590a1880d644cacbb
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2
Akademický článek
Synaptic Dysfunction by Mutations in GRIN2B: Influence of Triheteromeric NMDA Receptors on Gain-of-Function and Loss-of-Function Mutant Classification
Autor: Marwa Elmasri, James S. Lotti, Wajeeha Aziz, Oliver G. Steele, Eirini Karachaliou, Kenji Sakimura, Kasper B. Hansen, Andrew C. Penn
Publikováno v: Brain Sciences, Vol 12, Iss 6, p 789 (2022)
GRIN2B mutations are rare but often associated with patients having severe neurodevelopmental disorders with varying range of symptoms such as intellectual disability, developmental delay and epilepsy. Patient symptoms likely arise from mutations dis
Externí odkaz: https://doaj.org/article/8e4d846d461544c2aa4a98e20d3181e3
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5
Utilising failure history to improve maintenance planning
Autor: Simon Didriksen, Kasper B. Hansen, Kristoffer V. Sigsgaard, Niels Henrik Mortensen, Julie K. Agergaard, Jingrui Ge
Publikováno v: Didriksen, S, Hansen, K B, Sigsgaard, K V, Mortensen, N H, Agergaard, J K & Ge, J 2022, Utilising failure history to improve maintenance planning . in N H Mortensen, C T Hansen & M Deininger (eds), Proceedings of NordDesign 2022 . vol. DS 118, Cambridge University Press, NordDesign 2022, Copenhagen, Denmark, 16/08/2022 . https://doi.org/10.35199/NORDDESIGN2022.42
In the literature, improving decision support by utilisation of failure history maintenance data is considered to hold a great potential for enhancing the maintenance planning process, as de-cisions are based on experience and available information.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ec2d5b8011fe41e6b59bc751a2197ee
https://doi.org/10.35199/norddesign2022.42
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6
Derivatives of (R)-3-(5-furanyl)carboxamido-2-aminopropanoic acid as potent NMDA receptor glycine site agonists with GluN2 subunit-specific activity
Autor: Fabao Zhao, Unai Atxabal, Sofia Mariottini, Feng Yi, James S. Lotti, Nirvan Rouzbeh, Na Liu, Lennart Bunch, Kasper B. Hansen, Rasmus P. Clausen
Publikováno v: J Med Chem
NMDA receptors mediate glutamatergic neurotransmission and are therapeutic targets due to their involvement in a variety of psychiatric and neurological disorders. Here, we describe the design and synthesis of a series of (R)-3-(5-fyranyl)carboxamido
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcb36409a760650421a74184de92e6a5
https://europepmc.org/articles/PMC9437973/
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8
Stereoselective synthesis of novel 2′-(S)-CCG-IV analogues as potent NMDA receptor agonists
Autor: Rasmus P. Clausen, Tung-Chung Mou, Alex Maolanon, Kasper B. Hansen, Feng Yi, David Kawiecki, Jed T. Syrenne, Athanasios Papangelis
Publikováno v: Maolanon, A, Papangelis, A, Kawiecki, D, Mou, T C, Syrenne, J T, Yi, F, Hansen, K B & Clausen, R P 2021, ' Stereoselective synthesis of novel 2′-(S)-CCG-IV analogues as potent NMDA receptor agonists ', European Journal of Medicinal Chemistry, vol. 212, 113099 . https://doi.org/10.1016/j.ejmech.2020.113099
Eur J Med Chem
We developed a versatile stereoselective route for the synthesis of new 2′-(S)-CCG-IV analogues. The route allows for late stage diversification and thereby provides access to a great variety of conformationally restricted cyclopropyl glutamate ana
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91c726bb70abb842082d935e18220009
https://curis.ku.dk/ws/files/332600413/1_s2.0_S0223523420310710_am.pdf
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10
Stereoselective Synthesis of New (2
Autor: Silke, Kayser, Jacob C, Hansen, Markus, Staudt, Aleksandra, Moroz, Younes, Larsen, Piero, Temperini, Feng, Yi, Jed T, Syrenne, Niels, Krogsgaard-Larsen, Stylianos, Iliadis, Birgitte, Nielsen, Kasper B, Hansen, Darryl S, Pickering, Lennart, Bunch
Publikováno v: ACS Chem Neurosci
Competitive antagonists for ionotropic glutamate receptors (iGluRs) are highly valuable tool compounds for studying health and disease states in the central nervous system. However, only few subtype selective tool compounds are available and the disc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9854d2d039a9d944b85aa9789f222513
https://pubmed.ncbi.nlm.nih.gov/32065744
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