IFN-γR/STAT1 signaling in recipient hematopoietic antigen-presenting cells suppresses graft-versus-host disease

Autor: Caisheng Lu, Huihui Ma, Liangsong Song, Hui Wang, Lily Wang, Shirong Li, Stephen M. Lagana, Antonia R. Sepulveda, Kasper Hoebe, Samuel S. Pan, Yong-Guang Yang, Suzanne Lentzsch, Markus Y. Mapara

Publikováno v: The Journal of Clinical Investigation, Vol 133, Iss 3 (2023)

The absence of IFN-γ receptor (IFN-γR) or STAT1 signaling in donor cells has been shown to result in reduced induction of acute graft-versus-host disease (GVHD). In this study, we unexpectedly observed increased activation and expansion of donor ly

Externí odkaz: https://doaj.org/article/b41b9fa9ee7b40fe937c4da4b57c6cca

CD244 represents a new therapeutic target in head and neck squamous cell carcinoma

Autor: Laura Conforti, Laura Agresta, Maria Lehn, Kristin Lampe, Rachel Cantrell, Cassandra Hennies, Sara Szabo, Trisha Wise-Draper, Kasper Hoebe, Edith M Janssen

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)

Background Developing novel strategies to overcome the immunosuppressive tumor microenvironment is a critically important area of cancer therapy research. Here, we assess the therapeutic potential of CD244 (2B4/signaling lymphocyte activation molecul

Externí odkaz: https://doaj.org/article/399509727da14162bd5e3fe439ed4134

The Variable Genomic NK Cell Receptor Locus Is a Key Determinant of CD4+ T Cell Responses During Viral Infection

Autor: Jana Raynor, Adora Lin, Sarah A. Hummel, Kristin Lampe, Michael Jordan, Kasper Hoebe, David A. Hildeman

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Increasing evidence points to a key role for NK cells in controlling adaptive immune responses. In studies examining the role of CD1d on CD4+ T cell responses, we found that a line of CD1d-deficient mice on the C57BL/6J background had a homozygous 12

Externí odkaz: https://doaj.org/article/a73f170725f04db8a4eb0e4e13944ccd

The lncRNA LUCAT1 is elevated in inflammatory disease and restrains inflammation by regulating the splicing and stability of NR4A2

Autor: Tim Vierbuchen, Shiuli Agarwal, John L. Johnson, Liraz Galia, Xuqiu Lei, Karina Stein, David Olagnier, Karoline I. Gaede, Christian Herzmann, Christian K. Holm, Holger Heine, Athma Pai, Aisling O’Hara Hall, Kasper Hoebe, Katherine A. Fitzgerald

Publikováno v: Vierbuchen, T, Agarwal, S, Johnson, J L, Galia, L, Lei, X, Stein, K, Olagnier, D, Gaede, K I, Herzmann, C, Holm, C K, Heine, H, Pai, A, O'Hara Hall, A, Hoebe, K & Fitzgerald, K A 2023, ' The lncRNA LUCAT1 is elevated in inflammatory disease and restrains inflammation by regulating the splicing and stability of NR4A2 ', Proceedings of the National Academy of Sciences of the United States of America, vol. 120, no. 1, pp. e2213715120 . https://doi.org/10.1073/pnas.2213715120

The nuclear long non-coding RNA LUCAT1 has previously been identified as a negative feedback regulator of type I interferon and inflammatory cytokine expression in human myeloid cells. Here, we define the mechanistic basis for the suppression of infl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4119871f4c6d7df23af628c24378908e
https://pubmed.ncbi.nlm.nih.gov/36577072

TCR and IL-7 Signaling Are Altered in the Absence of Functional GTPase of the Immune Associated Nucleotide Binding Protein 5 (GIMAP5).

Autor: Xi-Lin Chen, Daniel Serrano, Farnaz Ghobadi, Marian Mayhue, Kasper Hoebe, Subburaj Ilangumaran, Sheela Ramanathan

Publikováno v: PLoS ONE, Vol 11, Iss 3, p e0151837 (2016)

GTPase of the immune associated nucleotide binding protein (GIMAP) family of proteins are expressed essentially in cells of the hematopoietic system. Mutation in the founding member of this gene family, Gimap5, results in the lymphopenic phenotype in

Externí odkaz: https://doaj.org/article/dc3ce9249b754dedaae5216bd7312f99