Identification of a window of androgen sensitivity for somatic cell function in human fetal testis cultured ex vivo

Autor: Malene Lundgaard Riis, Gabriele Matilionyte, John E. Nielsen, Cecilie Melau, David Greenald, Kristine Juul Hare, Lea Langhoff Thuesen, Eva Dreisler, Kasper Aaboe, Pia Tutein Brenøe, Anna-Maria Andersson, Jakob Albrethsen, Hanne Frederiksen, Ewa Rajpert-De Meyts, Anders Juul, Rod T. Mitchell, Anne Jørgensen

Publikováno v: BMC Medicine, Vol 20, Iss 1, Pp 1-18 (2022)

Abstract Background Reduced androgen action during early fetal development has been suggested as the origin of reproductive disorders comprised within the testicular dysgenesis syndrome (TDS). This hypothesis has been supported by studies in rats dem

Externí odkaz: https://doaj.org/article/6faa0696ef594229b30882d592bea05d

Twelve weeks treatment with the DPP-4 inhibitor, sitagliptin, prevents degradation of peptide YY and improves glucose and non-glucose induced insulin secretion in patients with type 2 diabetes mellitus

Autor: Thure Krarup, Jens J. Holst, Tina Vilsbøll, Filip K. Knop, Kasper Aaboe, Sten Madsbad, Carolyn F. Deacon

Publikováno v: Diabetes, Obesity and Metabolism. 12:323-333

Aim: To examine the effects of 12 weeks of treatment with the DPP-4 inhibitor, sitagliptin, on gastrointestinal hormone responses to a standardized mixed meal and beta cell secretory capacity, measured as glucose and non-glucose induced insulin secre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d6f9b25aaf2f470f39f5cc6c3f74b12
https://doi.org/10.1111/j.1463-1326.2009.01167.x

[Metformin and the obstetric patient]

Autor: Katrine Dahl, Pedersen, Nathalie Søderhamn, Bülow, Kasper, Aaboe, Julie, Galsgaard, Helle Sand, Odgaard, Elisabeth Reinhardt, Mathiesen, Jeannet, Lauenborg

Publikováno v: Ugeskrift for laeger. 177(50)

Polycystic ovary syndrome (PCOS) is associated with insulin resistance, infertility, obesity and gestational complications. Metformin is widely used in fertility treatment of women with PCOS, due to a suggested positive effect of continued metformin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::84e18fcb3e58d2e82c8422ef55c3c895
https://pubmed.ncbi.nlm.nih.gov/26651913

Restoration of the insulinotropic effect of glucose-dependent insulinotropic polypeptide contributes to the antidiabetic effect of dipeptidyl peptidase-4 inhibitors

Autor: S. Akram, Thure Krarup, Jens J. Holst, Kasper Aaboe, Carolyn F. Deacon, Sten Madsbad

Publikováno v: Diabetes, obesitymetabolism. 17(1)

Aims To examine whether 12 weeks of treatment with a dipeptidyl peptidase-4 (DPP-4) inhibitor, sitagliptin, influences the insulin secretion induced by glucose, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) du

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e029212a024072d693ea3d3b5668bd5
https://pubmed.ncbi.nlm.nih.gov/25243647

Steroid-induced insulin resistance and impaired glucose tolerance are both associated with a progressive decline of incretin effect in first-degree relatives of patients with type 2 diabetes

Autor: Kasper Aaboe, Jan Erik Henriksen, Sten Madsbad, David Hebbelstrup Jensen, J. J. Holst, Troels Magelund Krarup, Anders Vølund

Publikováno v: Jensen, D H, Aaboe, K, Henriksen, J E, Vølund, A, Holst, J J, Madsbad, S & Krarup, T M 2012, ' Steroid-induced insulin resistance and impaired glucose tolerance are both associated with a progressive decline of incretin effect in first-degree relatives of patients with type 2 diabetes ', Diabetologia, vol. 55, no. 5, pp. 1406-16 . https://doi.org/10.1007/s00125-012-2459-7

The aim of this study was to evaluate the separate impact of insulin resistance and impaired glucose tolerance (IGT) on the incretin effect.Twenty-one healthy glucose-tolerant first-degree relatives of patients with type 2 diabetes underwent a 75 g O

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f91e708c464c9a6b8eaab0e48525970
https://pubmed.ncbi.nlm.nih.gov/22286551