Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Kaspar Podgorski"'
Autor:
Yusuke Nasu, Abhi Aggarwal, Giang N. T. Le, Camilla Trang Vo, Yuki Kambe, Xinxing Wang, Felix R. M. Beinlich, Ashley Bomin Lee, Tina R. Ram, Fangying Wang, Kelsea A. Gorzo, Yuki Kamijo, Marc Boisvert, Suguru Nishinami, Genki Kawamura, Takeaki Ozawa, Hirofumi Toda, Grant R. Gordon, Shaoyu Ge, Hajime Hirase, Maiken Nedergaard, Marie-Eve Paquet, Mikhail Drobizhev, Kaspar Podgorski, Robert E. Campbell
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract l-Lactate is increasingly appreciated as a key metabolite and signaling molecule in mammals. However, investigations of the inter- and intra-cellular dynamics of l-lactate are currently hampered by the limited selection and performance of l-
Externí odkaz:
https://doaj.org/article/92c1078698bf4a70b5ef20a844149591
Autor:
Lorenzo Calzado-Reyes, Ulku Cuhadar, Carlos Pascual-Caro, Aman S. Aberra, Abhi Aggarwal, Kaspar Podgorski, Michael B. Hoppa, Jaime De Juan-Sanz
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S301- (2023)
Externí odkaz:
https://doaj.org/article/aab42097b6514b11aee8c5a65806b305
Autor:
Yusuke Nasu, Ciaran Murphy-Royal, Yurong Wen, Jordan N. Haidey, Rosana S. Molina, Abhi Aggarwal, Shuce Zhang, Yuki Kamijo, Marie-Eve Paquet, Kaspar Podgorski, Mikhail Drobizhev, Jaideep S. Bains, M. Joanne Lemieux, Grant R. Gordon, Robert E. Campbell
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
l-lactate is an important intercellular energy currency. Here the authors report a genetically encoded biosensor eLACCO1.1 to monitor extracellular l-lactate; they use eLACCO1.1 to image extracellular l-lactate in cultured mammalian cells and brain t
Externí odkaz:
https://doaj.org/article/56b5eb5b8e5543099fe7a7880622d7ac
Autor:
Sheng-Yi Wu, Yurong Wen, Nelson B C Serre, Cathrine Charlotte Heiede Laursen, Andrea Grostøl Dietz, Brian R Taylor, Mikhail Drobizhev, Rosana S Molina, Abhi Aggarwal, Vladimir Rancic, Michael Becker, Klaus Ballanyi, Kaspar Podgorski, Hajime Hirase, Maiken Nedergaard, Matyáš Fendrych, M Joanne Lemieux, Daniel F Eberl, Alan R Kay, Robert E Campbell, Yi Shen
Publikováno v:
PLoS Biology, Vol 20, Iss 9, p e3001772 (2022)
Potassium ion (K+) plays a critical role as an essential electrolyte in all biological systems. Genetically-encoded fluorescent K+ biosensors are promising tools to further improve our understanding of K+-dependent processes under normal and patholog
Externí odkaz:
https://doaj.org/article/3acdec6eadb747dba6da2bd4ef33714b
Autor:
Ahmed S. Abdelfattah, Rosario Valenti, Jihong Zheng, Allan Wong, GENIE Project Team, Kaspar Podgorski, Minoru Koyama, Douglas S. Kim, Eric R. Schreiter
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Genetically encoded voltage indicators (GEVIs) allow visualisation of fast action potentials in neurons but most are bright at rest and dimmer during an action potential. Here, the authors engineer electrochromic FRET GEVIs with fast, bright and posi
Externí odkaz:
https://doaj.org/article/2ea2ff2c1bd44acdb9e04c2ab44cdf71
Autor:
Changjia Cai, Johannes Friedrich, Amrita Singh, M Hossein Eybposh, Eftychios A Pnevmatikakis, Kaspar Podgorski, Andrea Giovannucci
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 4, p e1008806 (2021)
Voltage imaging enables monitoring neural activity at sub-millisecond and sub-cellular scale, unlocking the study of subthreshold activity, synchrony, and network dynamics with unprecedented spatio-temporal resolution. However, high data rates (>800M
Externí odkaz:
https://doaj.org/article/3b0eff8c33ef4d05b4a80f68b3794f69
Publikováno v:
Frontiers in Neural Circuits, Vol 14 (2020)
Determining how neurons transform synaptic input and encode information in action potential (AP) firing output is required for understanding dendritic integration, neural transforms and encoding. Limitations in the speed of imaging 3D volumes of brai
Externí odkaz:
https://doaj.org/article/968b00fd99d0400c9cb41e03cac03398
Publikováno v:
PLoS Biology, Vol 10, Iss 1, p e1001236 (2012)
Sensory experience drives dramatic structural and functional plasticity in developing neurons. However, for single-neuron plasticity to optimally improve whole-network encoding of sensory information, changes must be coordinated between neurons to en
Externí odkaz:
https://doaj.org/article/84f540209ed14584b065fb45fdb60d84
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51980 (2012)
Fluorescent dyes that are bright, stable, small, and biocompatible are needed for high-sensitivity two-photon imaging, but the combination of these traits has been elusive. We identified a class of squaraine derivatives with large two-photon action c
Externí odkaz:
https://doaj.org/article/b19845a80d584e9e8be81ebffcd898b2
Autor:
Yusuke Nasu, Abhi Aggarwal, Giang N. T. Le, Yuki Kamijo, Marc Boisvert, Marie-Eve Paquet, Mikhail Drobizhev, Kaspar Podgorski, Robert E. Campbell
l-Lactate is increasingly appreciated as a key metabolite and signaling molecule in mammals. To enable investigations of both the inter- and intra-cellular dynamics ofl-Lactate, we develop a second-generation green fluorescent extracellularl-Lactate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34d4a29262d0ebe4ba5b5b03195835e5
https://doi.org/10.1101/2022.12.27.522013
https://doi.org/10.1101/2022.12.27.522013