Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Kaspar Kevvai"'
Autor:
Michael E. Pyne, James A. Bagley, Lauren Narcross, Kaspar Kevvai, Kealan Exley, Meghan Davies, Qingzhao Wang, Malcolm Whiteway, Vincent J. J. Martin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Saccharomyces cerevisiae is a workhorse of industrial biotechnology owing to the organism’s prominence in alcohol fermentation and the suite of sophisticated genetic tools available to manipulate its metabolism. However, S. cerevisiae is n
Externí odkaz:
https://doaj.org/article/5ee80e772d7d43c7bc892ed4826582d3
Autor:
Michael E. Pyne, Kaspar Kevvai, Parbir S. Grewal, Lauren Narcross, Brian Choi, Leanne Bourgeois, John E. Dueber, Vincent J. J. Martin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Plants synthesize more than 3000 tetrahydroisoquinoline (THIQ) alkaloids, but only a few of them have been produced by engineered microbes and titers are very low. Here, the authors increase (S)-reticuline titer to 4.6 g/L and repurpose the yeast Ehr
Externí odkaz:
https://doaj.org/article/1711736c3c694987b81eeec5d825890d
Autor:
Lauren Narcross, Michael E. Pyne, Kaspar Kevvai, Ka-Hei Siu, John E. Dueber, Vincent J. J. Martin
The benzylisoquinoline alkaloid (BIA) family of tetrahydroisoquinolines (THIQs) comprises over 2,500 members, including the pharmaceuticals morphine, codeine, and papaverine as well as the antibiotics sanguinarine and chelerythrine used in animal hus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92f6998ca3d3e8ce612be2b7976df778
https://doi.org/10.1101/2023.05.19.541502
https://doi.org/10.1101/2023.05.19.541502
Autor:
Michael E. Pyne, James A. Bagley, Lauren Narcross, Kaspar Kevvai, Kealan Exley, Meghan Davies, Qingzhao Wang, Malcolm Whiteway, Vincent J.J. Martin
Saccharomyces cerevisiae is a workhorse of industrial biotechnology owing to the organism’s prominence in alcohol fermentation and the suite of sophisticated genetic tools available to manipulate its metabolism. However, S. cerevisiae is not suited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ed600ea452b89b7956abd36dd4cc9ad
https://doi.org/10.1101/2023.04.23.537879
https://doi.org/10.1101/2023.04.23.537879
Autor:
Kaspar Kevvai, Leanne Bourgeois, Brian Choi, John E. Dueber, Parbir Grewal, Vincent J. J. Martin, Lauren Narcross, Michael E. Pyne
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Nature Communications
Nature Communications
The tetrahydroisoquinoline (THIQ) moiety is a privileged substructure of many bioactive natural products and semi-synthetic analogs. Plants manufacture more than 3,000 THIQ alkaloids, including the opioids morphine and codeine. While microbial specie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f8d447284b05a931293aa9e121524d
http://link.springer.com/article/10.1038/s41467-020-17172-x
http://link.springer.com/article/10.1038/s41467-020-17172-x
Autor:
Parbir Grewal, Lauren Narcross, Martin Vjj, Michael E. Pyne, Leanne Bourgeois, Kaspar Kevvai, Bernard Choi, John E. Dueber
The tetrahydroisoquinoline (THIQ) moiety is a privileged substructure of many bioactive natural products and semi-synthetic analogues. The plant kingdom manufactures more than 3,000 THIQ alkaloids, including the opioids morphine and codeine. While mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::189504dd9f1c0c828883575d63f859fa
Publikováno v:
Journal of the Institute of Brewing. 122:110-115
The efficiency of nitrogen use by yeast is one of the key determinants of the successful completion of alcoholic fermentations. In this work the growth of Saccharomyces cerevisiae S288c in a synthetic medium containing ammonia and free amino acids, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d411003ea02cce25276b952646241770
https://doi.org/10.1002/jib.298
https://doi.org/10.1002/jib.298
Publikováno v:
Analytical and bioanalytical chemistry. 409(27)
Standardized analytical methods, where each B vitamin is extracted from a given sample individually using separate procedures, typically ensure that the extraction conditions provide the maximum recovery of each vitamin. However, in the human gastroi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f76263b52e93bbfa23e6b103b3acbc9
https://pubmed.ncbi.nlm.nih.gov/28871404
https://pubmed.ncbi.nlm.nih.gov/28871404
Publikováno v:
World Journal of Microbiology and Biotechnology. 30:2351-2359
The uptake and accumulation of the B-group vitamins thiamine, riboflavin, nicotinamide, pantothenic acid and pyridoxine in Saccharomyces cerevisiae was studied by gradually increasing the specific dosage of vitamins in an ethanol-stat fed-batch cultu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d70f5b754f38a60270e39da1fc524df
https://doi.org/10.1007/s11274-014-1660-x
https://doi.org/10.1007/s11274-014-1660-x
Publikováno v:
Applied Microbiology and Biotechnology. 87:175-183
Shot-wise supplementation of cysteine to a yeast culture is a common means of promoting glutathione (GSH) production. In the present work, we study the accumulation kinetics of cysteine, gamma-glutamylcysteine, and GSH and the expression of genes inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17ccceaa8f9c6612cc266a83adb56f81
https://doi.org/10.1007/s00253-010-2502-x
https://doi.org/10.1007/s00253-010-2502-x