Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Kaspar Gierke"'
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Vision is our primary sense, and maintaining it throughout our lifespan is crucial for our well-being. However, the retina, which initiates vision, suffers from an age-related, irreversible functional decline. What causes this functional decline, and
Externí odkaz:
https://doaj.org/article/13df7445e6b74d43bc7314596f6c8259
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Mammalian cone photoreceptors enable through their sophisticated synapse the high-fidelity transfer of visual information to second-order neurons in the retina. The synapse contains a proteinaceous organelle, called the synaptic ribbon, which tethers
Externí odkaz:
https://doaj.org/article/7265294961e641dd871a3b39b42b72e1
Autor:
Rene Barro-Soria, Alejandro Caicedo, Herbert Jägle, Laura Merkel, Na Zhao, Gabriel Knop, Kaspar Gierke, Andrea Dannullis, Hayo Castrop, Johann Helmut Brandstätter, Frank Kirchhoff, Andreas Feigenspan, Olaf Strauß
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Abstract Fast, precise and sustained neurotransmission requires graded Ca2+ signals at the presynaptic terminal. Neurotransmitter release depends on a complex interplay of Ca2+ fluxes and Ca2+ buffering in the presynaptic terminal that is not fully u
Externí odkaz:
https://doaj.org/article/0e7bea7f490544e5b2646f64c985bf98
Autor:
Andreas Feigenspan, Nina Stallwitz, Julia von Wittgenstein, Norbert Babai, Anneka Joachimsthaler, Miriam Ryl, Renato Frischknecht, Kaspar Gierke, Alexander Urbasik, Anna Fejtova, Johann Helmut Brandstätter, Jan Kremers
Bassoon (BSN) is a presynaptic cytomatrix protein ubiquitously present at chemical synapses of the central nervous system, where it regulates synaptic vesicle replenishment and organizes voltage‐gated Ca2+ channels. In sensory photoreceptor synapse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a398f1189ae16ae63ac94972c5e7ffe
https://opus4.kobv.de/opus4-fau/frontdoor/index/index/docId/16608
https://opus4.kobv.de/opus4-fau/frontdoor/index/index/docId/16608
Publikováno v:
Investigative Opthalmology & Visual Science. 63:21
Cone photoreceptors of the retina use a sophisticated ribbon-containing synapse to convert light-dependent changes in membrane potential into release of synaptic vesicles (SVs). We aimed to study the functional and structural maturation of mouse cone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::877399db5fefbed951f62af0500bf1ed
https://doi.org/10.1167/iovs.63.3.21
https://doi.org/10.1167/iovs.63.3.21
Autor:
Frederique Varoqueaux, Jan Kremers, Julia von Wittgenstein, Anneka Joachimsthaler, Benjamin H. Cooper, Johann Helmut Brandstätter, Maike Hemmerlein, Kaspar Gierke, Jenny Atorf, Hanna Regus-Leidig
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 7848, p 7848 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 21
International Journal of Molecular Sciences
Volume 21
Issue 21
Munc13 isoforms are constituents of the presynaptic compartment of chemical synapses, where they govern important steps in preparing synaptic vesicles for exocytosis. The role of Munc13-1, -2 and -3 is well documented in brain neurons, but less is kn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b949c479a54c2a24f0b6814ece1d0199
https://www.mdpi.com/1422-0067/21/21/7848
https://www.mdpi.com/1422-0067/21/21/7848
Autor:
Andreas Feigenspan, Julia von Wittgenstein, Norbert Babai, Kaspar Gierke, Johann Helmut Brandstätter
Publikováno v:
Acta physiologica (Oxford, England)REFERENCES. 231(3)
Aim Off cone bipolar cells of the mammalian retina connect to cone photoreceptor synaptic terminals via non-invaginating flat contacts at a considerable distance from the only established neurotransmitter release site so far, the synaptic ribbon. Dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8303646ce615592dd9a0f28849f0f74
https://pubmed.ncbi.nlm.nih.gov/33222426
https://pubmed.ncbi.nlm.nih.gov/33222426
Autor:
Hanna Regus-Leidig, Anneka Joachimsthaler, Andreas Feigenspan, Martina Löhner, Johann Helmut Brandstätter, Kaspar Gierke, Jan Kremers, Susanne Schoch, Jenny Atorf, Tanja M. Müller, Henrik Martens, Angela Peukert, Norbert Babai
Publikováno v:
The Journal of Neuroscience. 37:7848-7863
RAB3A-interacting molecule (RIM) proteins are important regulators of transmitter release from active zones. At conventional chemical synapses, RIMs contribute substantially to vesicle priming and docking and their loss reduces the readily releasable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8a68f20d5cb4f5b72183eae70e61175
https://doi.org/10.1523/jneurosci.2795-16.2017
https://doi.org/10.1523/jneurosci.2795-16.2017
Autor:
Craig C. Garner, Frauke Ackermann, Zsuzsanna Izsvák, Tanja M. Müller, Jan Kremers, F. Kent Hamra, Kaspar Gierke, Heinrich Sticht, Johann Helmut Brandstätter, Hanna Regus-Leidig, Anna Fejtova, Anneka Joachimsthaler
Publikováno v:
The journal of neuroscience 39(14), 2606-2619 (2019). doi:10.1523/JNEUROSCI.2038-18.2019
Active zones at chemical synapses are highly specialized sites for the regulated release of neurotransmitters. Despite a high degree of active zone protein conservation in vertebrates, every type of chemical synapse expresses a given set of protein i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd145185aa81978442f0e374e6c78d3f
Autor:
Andreas Feigenspan, Tanja M. Müller, Johann Helmut Brandstätter, Hanna Regus-Leidig, Kaspar Gierke, Norbert Babai
Publikováno v:
Acta Physiologica. 226:e13241
Aim A key feature of the mammalian retina is the segregation of visual information in parallel pathways, starting at the photoreceptor terminals. Cone photoreceptors establish synaptic contacts with On bipolar and horizontal cells at invaginating, ri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6751b71de8134be1848d9c2b43b3ece4
https://doi.org/10.1111/apha.13241
https://doi.org/10.1111/apha.13241